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The immunobiological and clinical role of vitamin D in obstructive lung diseases.
Minerva Med 2016; 107(3 Suppl 1):12-9MM

Abstract

Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD). Recent studies have demonstrated that vitamin D and its deficiency have a number of biological effects which are potentially important in altering the pathogenesis and severity of both asthma and COPD. Vitamin D may improve lung function and response to steroids therapy, reduce airway remodeling and disease exacerbations. The aim of this study is to review the role of Vitamin D in asthma and COPD.

Authors+Show Affiliations

Pulmonary Medicine Unit, Department of Cardiovascular and Thoracic Surgery, Città della Salute e della Scienza University Hospital, University of Turin, Turin, Italy - psolidoro@cittadellasalute.to.it.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27424501

Citation

Solidoro, Paolo, et al. "The Immunobiological and Clinical Role of Vitamin D in Obstructive Lung Diseases." Minerva Medica, vol. 107, no. 3 Suppl 1, 2016, pp. 12-9.
Solidoro P, Bellocchia M, Facchini F. The immunobiological and clinical role of vitamin D in obstructive lung diseases. Minerva Med. 2016;107(3 Suppl 1):12-9.
Solidoro, P., Bellocchia, M., & Facchini, F. (2016). The immunobiological and clinical role of vitamin D in obstructive lung diseases. Minerva Medica, 107(3 Suppl 1), pp. 12-9.
Solidoro P, Bellocchia M, Facchini F. The Immunobiological and Clinical Role of Vitamin D in Obstructive Lung Diseases. Minerva Med. 2016;107(3 Suppl 1):12-9. PubMed PMID: 27424501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immunobiological and clinical role of vitamin D in obstructive lung diseases. AU - Solidoro,Paolo, AU - Bellocchia,Michela, AU - Facchini,Fabrizio, PY - 2016/7/19/entrez PY - 2016/7/19/pubmed PY - 2017/2/28/medline SP - 12 EP - 9 JF - Minerva medica JO - Minerva Med. VL - 107 IS - 3 Suppl 1 N2 - Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD). Recent studies have demonstrated that vitamin D and its deficiency have a number of biological effects which are potentially important in altering the pathogenesis and severity of both asthma and COPD. Vitamin D may improve lung function and response to steroids therapy, reduce airway remodeling and disease exacerbations. The aim of this study is to review the role of Vitamin D in asthma and COPD. SN - 1827-1669 UR - https://www.unboundmedicine.com/medline/citation/27424501/The_immunobiological_and_clinical_role_of_vitamin_D_in_obstructive_lung_diseases_ L2 - http://www.minervamedica.it/index2.t?show=R10Y2016S02A0012 DB - PRIME DP - Unbound Medicine ER -