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Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study of 316 Cases.
Clin Breast Cancer. 2016 12; 16(6):507-513.CB

Abstract

BACKGROUND

Management recommendations for lobular neoplasia (LN) including lobular carcinoma-in-situ (LCIS) and atypical lobular hyperplasia (ALH) diagnosed in core biopsies (CB) are controversial. Our aim was to prospectively identify a subset of patients who do not require subsequent surgical excision (SE).

PATIENTS AND METHODS

All patients diagnosed with LN on CB were enrolled and referred for SE. Cases with coexistent ductal carcinoma-in-situ or invasive carcinoma were excluded. Cases with coexistent ductal atypia (LN-DA) and LCIS variants (LN-V) were separated from pure classic LN (LN-C). Dedicated breast pathologists and radiologists reviewed cases with careful imaging/pathology correlation.

RESULTS

Of 13,772 total percutaneous breast CB procedures, 302 of 370 patients diagnosed with LN underwent SE. Upgrade to carcinoma was present in 3.5% (8/228) LN-C, 26.7% LN-V (4/15), and 28.3% LN-DA (15/53). Calcifications were the imaging target for 180 (79%) of 228 LN-C cases; 7 were associated with upgrade (3.9%). Upgrades were rare for mass lesions (1/32) and magnetic resonance imaging-targeted lesions (0/14). Upgrades were similar for ALH and LCIS (3.4% vs. 4.5%). During postsurgical follow-up (mean, 34.5 months), 6.5% LN-C patients developed carcinoma in either breast.

CONCLUSION

Although LN with nonclassic morphology or with associated ductal atypia requires SE, this can be avoided in LN-C diagnosed on CB targeting calcifications when careful imaging/pathology correlation is applied. Until larger numbers are studied, excising LN-C diagnosed as masses or magnetic resonance imaging-detected lesions may be prudent. Regardless of their selection for surgical management, LN patients need close surveillance in view of their long-term risk of breast cancer.

Authors+Show Affiliations

Allina Health Laboratories, Hospital Pathology Associates HPA, Minneapolis, MN.Allina Health System, Piper Breast Center, Minneapolis, MN.Suburban Radiologic Consultants Ltd., Minneapolis, MN.Allina Health System, Piper Breast Center, Minneapolis, MN.Allina Health System, Virginia Piper Cancer Institute, Minneapolis, MN.Allina Health System, Virginia Piper Cancer Institute, Minneapolis, MN. Electronic address: karen.swenson2@allina.com.Allina Health System, Virginia Piper Cancer Institute, Minneapolis, MN.Allina Health System, United Hospital Piper Breast Center, St Paul, MN.Allina Health Laboratories, Hospital Pathology Associates HPA, Minneapolis, MN.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27425222

Citation

Susnik, Barbara, et al. "Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study of 316 Cases." Clinical Breast Cancer, vol. 16, no. 6, 2016, pp. 507-513.
Susnik B, Day D, Abeln E, et al. Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study of 316 Cases. Clin Breast Cancer. 2016;16(6):507-513.
Susnik, B., Day, D., Abeln, E., Bowman, T., Krueger, J., Swenson, K. K., Tsai, M. L., Bretzke, M. L., & Lillemoe, T. J. (2016). Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study of 316 Cases. Clinical Breast Cancer, 16(6), 507-513. https://doi.org/10.1016/j.clbc.2016.06.003
Susnik B, et al. Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study of 316 Cases. Clin Breast Cancer. 2016;16(6):507-513. PubMed PMID: 27425222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study of 316 Cases. AU - Susnik,Barbara, AU - Day,Deborah, AU - Abeln,Ellen, AU - Bowman,Tara, AU - Krueger,Janet, AU - Swenson,Karen K, AU - Tsai,Michaela L, AU - Bretzke,Margit L, AU - Lillemoe,Tamera J, Y1 - 2016/06/14/ PY - 2015/12/17/received PY - 2016/04/05/revised PY - 2016/06/05/accepted PY - 2016/7/19/pubmed PY - 2017/7/18/medline PY - 2016/7/19/entrez KW - Atypical lobular hyperplasia KW - Breast cancer KW - Imaging pathology correlation KW - Lobular carcinoma in situ KW - Upgrade SP - 507 EP - 513 JF - Clinical breast cancer JO - Clin Breast Cancer VL - 16 IS - 6 N2 - BACKGROUND: Management recommendations for lobular neoplasia (LN) including lobular carcinoma-in-situ (LCIS) and atypical lobular hyperplasia (ALH) diagnosed in core biopsies (CB) are controversial. Our aim was to prospectively identify a subset of patients who do not require subsequent surgical excision (SE). PATIENTS AND METHODS: All patients diagnosed with LN on CB were enrolled and referred for SE. Cases with coexistent ductal carcinoma-in-situ or invasive carcinoma were excluded. Cases with coexistent ductal atypia (LN-DA) and LCIS variants (LN-V) were separated from pure classic LN (LN-C). Dedicated breast pathologists and radiologists reviewed cases with careful imaging/pathology correlation. RESULTS: Of 13,772 total percutaneous breast CB procedures, 302 of 370 patients diagnosed with LN underwent SE. Upgrade to carcinoma was present in 3.5% (8/228) LN-C, 26.7% LN-V (4/15), and 28.3% LN-DA (15/53). Calcifications were the imaging target for 180 (79%) of 228 LN-C cases; 7 were associated with upgrade (3.9%). Upgrades were rare for mass lesions (1/32) and magnetic resonance imaging-targeted lesions (0/14). Upgrades were similar for ALH and LCIS (3.4% vs. 4.5%). During postsurgical follow-up (mean, 34.5 months), 6.5% LN-C patients developed carcinoma in either breast. CONCLUSION: Although LN with nonclassic morphology or with associated ductal atypia requires SE, this can be avoided in LN-C diagnosed on CB targeting calcifications when careful imaging/pathology correlation is applied. Until larger numbers are studied, excising LN-C diagnosed as masses or magnetic resonance imaging-detected lesions may be prudent. Regardless of their selection for surgical management, LN patients need close surveillance in view of their long-term risk of breast cancer. SN - 1938-0666 UR - https://www.unboundmedicine.com/medline/citation/27425222/Surgical_Outcomes_of_Lobular_Neoplasia_Diagnosed_in_Core_Biopsy:_Prospective_Study_of_316_Cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1526-8209(16)30145-8 DB - PRIME DP - Unbound Medicine ER -