Tags

Type your tag names separated by a space and hit enter

Pain-related stress in the Neonatal Intensive Care Unit and salivary cortisol reactivity to socio-emotional stress in 3-month-old very preterm infants.
Psychoneuroendocrinology. 2016 10; 72:161-5.P

Abstract

Very preterm (VPT) infants are hospitalized in the Neonatal Intensive Care Unit (NICU) and exposed to varying levels of skin-breaking procedures (pain-related stress), even in absence of severe clinical conditions. Repeated and prolonged pain exposure may alter hypothalamic-pituitary-adrenal (HPA) axis reactivity in VPT infants. During the post-discharge period, altered HPA axis reactivity has been documented in response to non-social stressors, using salivary cortisol as a biomarker. However, little is known about the effects of NICU pain-related stress on subsequent HPA axis reactivity to socio-emotional stress in infants. We examined the relationship between pain-related stress in NICU and HPA axis reactivity (i.e., salivary cortisol reactivity) to an age-appropriate socio-emotional condition in 37 healthy VPT infants compared to 53 full-term (FT) controls. The number of skin-breaking procedures was obtained across NICU stay for VPT infants. At 3 months (corrected age for prematurity), all infants participated in the maternal Face-to-Face Still-Face (FFSF) procedure, in order to assess HPA axis reactivity to socio-emotional stress (i.e., maternal unresponsiveness). VPT infants exhibited a blunted salivary cortisol reactivity, which was associated with the amount of skin-breaking procedures during NICU: greater pain-related stress predicted lower salivary cortisol reactivity, adjusting for neonatal confounders. These findings further advance our knowledge of how early exposure to pain-related stress in NICU contributes to the programming of an altered HPA axis reactivity to socio-emotional stress in 3-month-old VPT infants, even in the absence of major perinatal complications.

Authors+Show Affiliations

0-3 Centre for the at-Risk Infant, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy. Electronic address: livio.provenzi@bp.lnf.it.0-3 Centre for the at-Risk Infant, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy.NICU, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.0-3 Centre for the at-Risk Infant, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy.Biology Laboratory, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy.Bioinformatic Lab, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy.NICU, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Pediatric Unit, Fatebenefratelli Sacra Famiglia Hospital, Erba, Italy.Neuropsychiatry and Neurorehabilitation Unit, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy.0-3 Centre for the at-Risk Infant, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27428089

Citation

Provenzi, Livio, et al. "Pain-related Stress in the Neonatal Intensive Care Unit and Salivary Cortisol Reactivity to Socio-emotional Stress in 3-month-old Very Preterm Infants." Psychoneuroendocrinology, vol. 72, 2016, pp. 161-5.
Provenzi L, Giusti L, Fumagalli M, et al. Pain-related stress in the Neonatal Intensive Care Unit and salivary cortisol reactivity to socio-emotional stress in 3-month-old very preterm infants. Psychoneuroendocrinology. 2016;72:161-5.
Provenzi, L., Giusti, L., Fumagalli, M., Tasca, H., Ciceri, F., Menozzi, G., Mosca, F., Morandi, F., Borgatti, R., & Montirosso, R. (2016). Pain-related stress in the Neonatal Intensive Care Unit and salivary cortisol reactivity to socio-emotional stress in 3-month-old very preterm infants. Psychoneuroendocrinology, 72, 161-5. https://doi.org/10.1016/j.psyneuen.2016.07.010
Provenzi L, et al. Pain-related Stress in the Neonatal Intensive Care Unit and Salivary Cortisol Reactivity to Socio-emotional Stress in 3-month-old Very Preterm Infants. Psychoneuroendocrinology. 2016;72:161-5. PubMed PMID: 27428089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pain-related stress in the Neonatal Intensive Care Unit and salivary cortisol reactivity to socio-emotional stress in 3-month-old very preterm infants. AU - Provenzi,Livio, AU - Giusti,Lorenzo, AU - Fumagalli,Monica, AU - Tasca,Hilarj, AU - Ciceri,Francesca, AU - Menozzi,Giorgia, AU - Mosca,Fabio, AU - Morandi,Francesco, AU - Borgatti,Renato, AU - Montirosso,Rosario, Y1 - 2016/07/10/ PY - 2016/04/06/received PY - 2016/07/08/revised PY - 2016/07/08/accepted PY - 2016/7/19/entrez PY - 2016/7/19/pubmed PY - 2017/12/9/medline KW - Cortisol KW - Hypothalamic-pituitary-adrenal axis KW - Still-Face KW - Stress KW - Very preterm infants SP - 161 EP - 5 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 72 N2 - Very preterm (VPT) infants are hospitalized in the Neonatal Intensive Care Unit (NICU) and exposed to varying levels of skin-breaking procedures (pain-related stress), even in absence of severe clinical conditions. Repeated and prolonged pain exposure may alter hypothalamic-pituitary-adrenal (HPA) axis reactivity in VPT infants. During the post-discharge period, altered HPA axis reactivity has been documented in response to non-social stressors, using salivary cortisol as a biomarker. However, little is known about the effects of NICU pain-related stress on subsequent HPA axis reactivity to socio-emotional stress in infants. We examined the relationship between pain-related stress in NICU and HPA axis reactivity (i.e., salivary cortisol reactivity) to an age-appropriate socio-emotional condition in 37 healthy VPT infants compared to 53 full-term (FT) controls. The number of skin-breaking procedures was obtained across NICU stay for VPT infants. At 3 months (corrected age for prematurity), all infants participated in the maternal Face-to-Face Still-Face (FFSF) procedure, in order to assess HPA axis reactivity to socio-emotional stress (i.e., maternal unresponsiveness). VPT infants exhibited a blunted salivary cortisol reactivity, which was associated with the amount of skin-breaking procedures during NICU: greater pain-related stress predicted lower salivary cortisol reactivity, adjusting for neonatal confounders. These findings further advance our knowledge of how early exposure to pain-related stress in NICU contributes to the programming of an altered HPA axis reactivity to socio-emotional stress in 3-month-old VPT infants, even in the absence of major perinatal complications. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/27428089/Pain_related_stress_in_the_Neonatal_Intensive_Care_Unit_and_salivary_cortisol_reactivity_to_socio_emotional_stress_in_3_month_old_very_preterm_infants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(16)30225-6 DB - PRIME DP - Unbound Medicine ER -