Tags

Type your tag names separated by a space and hit enter

Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration Paradigm.
Curr Top Behav Neurosci. 2017; 32:133-143.CT

Abstract

Since the mid- to late 2000s, there has been a dramatic rise in the use and abuse of synthetic derivatives of cathinone, a stimulant alkaloid found in the African shrub Catha edulis. Cathinone novel psychoactive substances (NPS), also referred to as synthetic cathinones or "bath salt"-type drugs, have gained popularity among drug users due to their potency, low cost, ease of procurement, and diverse array of evolving chemical structures. While the ability of cathinone NPS to produce psychotomimetic effects, multiple organ system toxicity, and death in humans is well documented, there has been limited scientific investigation into the reinforcing effects and abuse liability of these drugs. In this chapter, we will summarize the existing literature on the reinforcing effects of cathinone NPS in rodents using the intravenous self-administration (IVSA) paradigm. We will also compare the ability of cathinone NPS to serve as reinforcers to that of classical psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (MDMA). The chapter will conclude with a summary and indications for future avenues of research on cathinone NPS.

Authors+Show Affiliations

Department of Psychology, Arizona State University, 871104, Tempe, AZ, 85287, USA.Department of Psychology, Arizona State University, 871104, Tempe, AZ, 85287, USA. foster.olive@asu.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

27431398

Citation

Watterson, Lucas R., and M Foster Olive. "Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration Paradigm." Current Topics in Behavioral Neurosciences, vol. 32, 2017, pp. 133-143.
Watterson LR, Olive MF. Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration Paradigm. Curr Top Behav Neurosci. 2017;32:133-143.
Watterson, L. R., & Olive, M. F. (2017). Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration Paradigm. Current Topics in Behavioral Neurosciences, 32, 133-143. https://doi.org/10.1007/7854_2016_33
Watterson LR, Olive MF. Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration Paradigm. Curr Top Behav Neurosci. 2017;32:133-143. PubMed PMID: 27431398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration Paradigm. AU - Watterson,Lucas R, AU - Olive,M Foster, PY - 2016/7/20/pubmed PY - 2017/7/14/medline PY - 2016/7/20/entrez KW - Animal model KW - Cathinone KW - Intravenous self-administration KW - Operant conditioning KW - Reinforcement SP - 133 EP - 143 JF - Current topics in behavioral neurosciences JO - Curr Top Behav Neurosci VL - 32 N2 - Since the mid- to late 2000s, there has been a dramatic rise in the use and abuse of synthetic derivatives of cathinone, a stimulant alkaloid found in the African shrub Catha edulis. Cathinone novel psychoactive substances (NPS), also referred to as synthetic cathinones or "bath salt"-type drugs, have gained popularity among drug users due to their potency, low cost, ease of procurement, and diverse array of evolving chemical structures. While the ability of cathinone NPS to produce psychotomimetic effects, multiple organ system toxicity, and death in humans is well documented, there has been limited scientific investigation into the reinforcing effects and abuse liability of these drugs. In this chapter, we will summarize the existing literature on the reinforcing effects of cathinone NPS in rodents using the intravenous self-administration (IVSA) paradigm. We will also compare the ability of cathinone NPS to serve as reinforcers to that of classical psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (MDMA). The chapter will conclude with a summary and indications for future avenues of research on cathinone NPS. SN - 1866-3370 UR - https://www.unboundmedicine.com/medline/citation/27431398/Reinforcing_Effects_of_Cathinone_NPS_in_the_Intravenous_Drug_Self_Administration_Paradigm_ L2 - https://dx.doi.org/10.1007/7854_2016_33 DB - PRIME DP - Unbound Medicine ER -