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[A Case of Fournier's Gangrene Caused by Small Intestinal Perforation during Bevacizumab Combination Chemotherapy].
Gan To Kagaku Ryoho. 2016 Jul; 43(7):909-11.GT

Abstract

A 51-year-old man underwent abdominoperineal resection for advanced rectal cancer at a hospital. He attended our outpatient clinic 58 months later with pain in the external genitalia, and was diagnosed with local pelvic recurrence and metastasis to the para-aortic lymph node and both adrenal glands. He received a total of 30 Gy of radiation for analgesia; subsequently, chemotherapy(mFOLFOX6 plus bevacizumab)was initiated. However, extreme left buttock and left femoral pain developed after the 6 courses of chemotherapy. Abdominal CT revealed Fournier's gangrene caused by small intestinal perforation. Emergency drainage under spinal anesthesia was immediately performed. Two additional drainage procedures were required thereafter and an ileostomy was constructed. The patient was discharged 100 days after the initial drainage. This is an extremely rare example of a bevacizumab-related small intestinal perforation that developed into Fournier's gan- grene.

Authors+Show Affiliations

Ishida T
Dept. of Surgery, Saiseikai Utsunomiya Hospital.
Shinozaki H
No affiliation info available
Ozawa H
No affiliation info available
Kobayashi T
No affiliation info available
Kato S
No affiliation info available
Wakabayashi T
No affiliation info available
Matsumoto K
No affiliation info available
Sasakura Y
No affiliation info available
Shimizu T
No affiliation info available
Terauchi T
No affiliation info available
Kimata M
No affiliation info available
Furukawa J
No affiliation info available
Kobayashi K
No affiliation info available
Ogata Y
No affiliation info available

MeSH

Antineoplastic Combined Chemotherapy ProtocolsBevacizumabChemoradiotherapyDrainageFatal OutcomeFluorouracilFournier GangreneHumansIntestinal PerforationIntestine, SmallLeucovorinMaleMiddle AgedOrganoplatinum CompoundsRectal Neoplasms

Pub Type(s)

Case Reports
Journal Article

Language

jpn

PubMed ID

27431640

Citation

Ishida, Takashi, et al. "[A Case of Fournier's Gangrene Caused By Small Intestinal Perforation During Bevacizumab Combination Chemotherapy]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 43, no. 7, 2016, pp. 909-11.
Ishida T, Shinozaki H, Ozawa H, et al. [A Case of Fournier's Gangrene Caused by Small Intestinal Perforation during Bevacizumab Combination Chemotherapy]. Gan To Kagaku Ryoho. 2016;43(7):909-11.
Ishida, T., Shinozaki, H., Ozawa, H., Kobayashi, T., Kato, S., Wakabayashi, T., Matsumoto, K., Sasakura, Y., Shimizu, T., Terauchi, T., Kimata, M., Furukawa, J., Kobayashi, K., & Ogata, Y. (2016). [A Case of Fournier's Gangrene Caused by Small Intestinal Perforation during Bevacizumab Combination Chemotherapy]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 43(7), 909-11.
Ishida T, et al. [A Case of Fournier's Gangrene Caused By Small Intestinal Perforation During Bevacizumab Combination Chemotherapy]. Gan To Kagaku Ryoho. 2016;43(7):909-11. PubMed PMID: 27431640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A Case of Fournier's Gangrene Caused by Small Intestinal Perforation during Bevacizumab Combination Chemotherapy]. AU - Ishida,Takashi, AU - Shinozaki,Hiroharu, AU - Ozawa,Hiroki, AU - Kobayashi,Toshimichi, AU - Kato,Subaru, AU - Wakabayashi,Taiga, AU - Matsumoto,Kenji, AU - Sasakura,Yuuichi, AU - Shimizu,Tetsuichiro, AU - Terauchi,Toshiaki, AU - Kimata,Masaru, AU - Furukawa,Junji, AU - Kobayashi,Kenji, AU - Ogata,Yoshiro, PY - 2016/7/20/entrez PY - 2016/7/20/pubmed PY - 2016/12/17/medline SP - 909 EP - 11 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 43 IS - 7 N2 - A 51-year-old man underwent abdominoperineal resection for advanced rectal cancer at a hospital. He attended our outpatient clinic 58 months later with pain in the external genitalia, and was diagnosed with local pelvic recurrence and metastasis to the para-aortic lymph node and both adrenal glands. He received a total of 30 Gy of radiation for analgesia; subsequently, chemotherapy(mFOLFOX6 plus bevacizumab)was initiated. However, extreme left buttock and left femoral pain developed after the 6 courses of chemotherapy. Abdominal CT revealed Fournier's gangrene caused by small intestinal perforation. Emergency drainage under spinal anesthesia was immediately performed. Two additional drainage procedures were required thereafter and an ileostomy was constructed. The patient was discharged 100 days after the initial drainage. This is an extremely rare example of a bevacizumab-related small intestinal perforation that developed into Fournier's gan- grene. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/27431640/[A_Case_of_Fournier's_Gangrene_Caused_by_Small_Intestinal_Perforation_during_Bevacizumab_Combination_Chemotherapy]_ DB - PRIME DP - Unbound Medicine ER -