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Central obesity and risks of pre- and postmenopausal breast cancer: a dose-response meta-analysis of prospective studies.
Obes Rev 2016; 17(11):1167-1177OR

Abstract

Epidemiologic evidence has shown inconsistent findings regarding the relationships between abdominal fatness, as measured by waist circumferences (WC) or waist-to-hip ratio (WHR), and risks of pre- and postmenopausal breast cancer (BC). A dose-response meta-analysis of prospective studies was conducted to address these issues. Potentially eligible studies were identified by searching PubMed and EMBASE databases, and by carefully reviewing the bibliographies of retrieved publications and related reviews. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. When the most fully adjusted RRs were combined, both WC (14 studies, RR per 10-cm increase = 1.06, 95% CI: 1.04-1.09, I2 = 29.9%) and WHR (15 studies, RR per 0.1-unit increase = 1.07, 95% CI: 1.01-1.14, I2 = 52.9%) were significantly positively associated with postmenopausal BC, but neither WC (eight studies, RR per 10-cm increase = 1.05, 95% CI: 0.99-1.10, I2 = 0%) nor WHR (11 studies, RR per 0.1-unit increase = 1.07, 95% CI: 0.95-1.21, I2 = 59.7%) were associated with premenopausal BC. The WHR-postmenopausal BC association lost statistical significance after correcting publication bias (RR per 0.1-unit increase = 1.06, 95% CI: 0.99-1.13). When considering BMI-adjusted RRs, WC was associated with both pre- (five studies, RR per 10-cm increase = 1.09, 95% CI: 1.02-1.16, I2 = 0%) and postmenopausal BC (seven studies, RR per 10-cm increase = 1.05, 95% CI: 1.02-1.08, I2 = 6.3%), whereas WHR was not associated with either pre- (seven studies, RR per 0.1-unit increase = 1.12, 95% CI: 0.94-1.34, I2 = 70.9%) or postmenopausal BC (eight studies, RR per 0.1-unit increase = 1.05, 95% CI: 0.98-1.13, I2 = 57.3%). Among non-current (former or never) users of hormone replacement therapy, the summary RR per 10-cm increase of postmenopausal BC associated with WC was 1.08 (95% CI: 1.03-1.05, I2 = 69.2%, seven studies; BMI-adjusted RR = 1.05, 95% CI: 1.02-1.09, I2 = 22.8%, four studies). This meta-analysis indicates that central obesity measured by WC, but not by WHR, is associated with modestly increased risks of both pre- and postmenopausal BC independent of general obesity.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.Department of Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.Division of Medical Genetics, Maternal and Child Health Hospital of Hunan Province, Changsha, China.Department of Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China. zhangyusong19@163.com.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China. qinliqiang@suda.edu.cn. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, Suzhou, China. qinliqiang@suda.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27432212

Citation

Chen, G-C, et al. "Central Obesity and Risks of Pre- and Postmenopausal Breast Cancer: a Dose-response Meta-analysis of Prospective Studies." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 17, no. 11, 2016, pp. 1167-1177.
Chen GC, Chen SJ, Zhang R, et al. Central obesity and risks of pre- and postmenopausal breast cancer: a dose-response meta-analysis of prospective studies. Obes Rev. 2016;17(11):1167-1177.
Chen, G. C., Chen, S. J., Zhang, R., Hidayat, K., Qin, J. B., Zhang, Y. S., & Qin, L. Q. (2016). Central obesity and risks of pre- and postmenopausal breast cancer: a dose-response meta-analysis of prospective studies. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 17(11), pp. 1167-1177. doi:10.1111/obr.12443.
Chen GC, et al. Central Obesity and Risks of Pre- and Postmenopausal Breast Cancer: a Dose-response Meta-analysis of Prospective Studies. Obes Rev. 2016;17(11):1167-1177. PubMed PMID: 27432212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central obesity and risks of pre- and postmenopausal breast cancer: a dose-response meta-analysis of prospective studies. AU - Chen,G-C, AU - Chen,S-J, AU - Zhang,R, AU - Hidayat,K, AU - Qin,J-B, AU - Zhang,Y-S, AU - Qin,L-Q, Y1 - 2016/07/19/ PY - 2016/04/20/received PY - 2016/05/20/revised PY - 2016/05/31/accepted PY - 2016/7/20/pubmed PY - 2017/9/28/medline PY - 2016/7/20/entrez KW - Breast cancer KW - central obesity KW - waist circumference KW - waist-to-hip ratio SP - 1167 EP - 1177 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 17 IS - 11 N2 - Epidemiologic evidence has shown inconsistent findings regarding the relationships between abdominal fatness, as measured by waist circumferences (WC) or waist-to-hip ratio (WHR), and risks of pre- and postmenopausal breast cancer (BC). A dose-response meta-analysis of prospective studies was conducted to address these issues. Potentially eligible studies were identified by searching PubMed and EMBASE databases, and by carefully reviewing the bibliographies of retrieved publications and related reviews. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. When the most fully adjusted RRs were combined, both WC (14 studies, RR per 10-cm increase = 1.06, 95% CI: 1.04-1.09, I2 = 29.9%) and WHR (15 studies, RR per 0.1-unit increase = 1.07, 95% CI: 1.01-1.14, I2 = 52.9%) were significantly positively associated with postmenopausal BC, but neither WC (eight studies, RR per 10-cm increase = 1.05, 95% CI: 0.99-1.10, I2 = 0%) nor WHR (11 studies, RR per 0.1-unit increase = 1.07, 95% CI: 0.95-1.21, I2 = 59.7%) were associated with premenopausal BC. The WHR-postmenopausal BC association lost statistical significance after correcting publication bias (RR per 0.1-unit increase = 1.06, 95% CI: 0.99-1.13). When considering BMI-adjusted RRs, WC was associated with both pre- (five studies, RR per 10-cm increase = 1.09, 95% CI: 1.02-1.16, I2 = 0%) and postmenopausal BC (seven studies, RR per 10-cm increase = 1.05, 95% CI: 1.02-1.08, I2 = 6.3%), whereas WHR was not associated with either pre- (seven studies, RR per 0.1-unit increase = 1.12, 95% CI: 0.94-1.34, I2 = 70.9%) or postmenopausal BC (eight studies, RR per 0.1-unit increase = 1.05, 95% CI: 0.98-1.13, I2 = 57.3%). Among non-current (former or never) users of hormone replacement therapy, the summary RR per 10-cm increase of postmenopausal BC associated with WC was 1.08 (95% CI: 1.03-1.05, I2 = 69.2%, seven studies; BMI-adjusted RR = 1.05, 95% CI: 1.02-1.09, I2 = 22.8%, four studies). This meta-analysis indicates that central obesity measured by WC, but not by WHR, is associated with modestly increased risks of both pre- and postmenopausal BC independent of general obesity. SN - 1467-789X UR - https://www.unboundmedicine.com/medline/citation/27432212/Central_obesity_and_risks_of_pre__and_postmenopausal_breast_cancer:_a_dose_response_meta_analysis_of_prospective_studies_ L2 - https://doi.org/10.1111/obr.12443 DB - PRIME DP - Unbound Medicine ER -