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Coffee consumption and risk of gastric cancer: an updated meta-analysis.
Asia Pac J Clin Nutr 2016; 25(3):578-88AP

Abstract

BACKGROUND AND OBJECTIVES

Coffee is one of the most widely consumed beverages worldwide, and many studies have investigated the association between coffee consumption and gastric cancer. However, the results are inconsistent. We conducted a systematic analysis of relevant population studies to derive a more precise estimation.

METHODS AND STUDY DESIGN

Cochrane library, PubMed and Embase databases were searched to identify studies that met predetermined inclusion criterion through July 2014. All epidemiologic studies regarding coffee consumption and gastric cancer risk were selected, and relative risks (RRs) with 95% confidence intervals (CIs) were calculated.

RESULTS

Twenty two studies (9 cohort and 13 case-control studies) involving 7,631 cases and 1,019,693 controls were included. The summary RR of gastric cancer was 0.94 (95% CI: 0.80-1.10) for the highest category of coffee consumption compared with the lowest category, and 0.93 (95% CI: 0.88-0.99) for coffee drinkers compared with nondrinkers. We stratified the population by coffee consumption. The pooled RR for the population with <1 cup/day, 1-2 cups/day and 3-4 cups/day coffee consumption compared with nondrinkers were 0.95 (95% CI: 0.84-1.08), 0.92 (95% CI: 0.82-1.03) and 0.88 (95% CI: 0.76-1.02), respectively, indicating that an increase in coffee consumption was associated with a decreased risk of gastric cancer. Furthermore, we stratified the studies by design, sex, population and time. A significant association between coffee intake and decreased gastric cancer risk was shown in case-control studies (RR=0.85, 95% CI: 0.77-0.95) and among the studies published over the last ten years (RR=0.88, 95% CI: 0.77-1.00).

CONCLUSIONS

Our meta-analysis suggested that coffee consumption might be associated with a decreased risk of gastric cancer.

Authors+Show Affiliations

Department of Laboratory Medicine, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, the Children's Hospital of Chongqing Medical University, Lab medicine of Yubei Maternity and Children Care Hospital, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing, China.Department of Laboratory Medicine, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, the Children's Hospital of Chongqing Medical University, Lab medicine of Yubei Maternity and Children Care Hospital, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing, China.Department II of Orthopaedics, Stem Cell Biology and Therapy Laboratory, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, the Children's Hospital of Chongqing Medical University, Chongqing, China.Department II of Orthopaedics, Stem Cell Biology and Therapy Laboratory, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, the Children's Hospital of Chongqing Medical University, Chongqing, China. Email: yuxisu@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

27440694

Citation

Xie, Yan, et al. "Coffee Consumption and Risk of Gastric Cancer: an Updated Meta-analysis." Asia Pacific Journal of Clinical Nutrition, vol. 25, no. 3, 2016, pp. 578-88.
Xie Y, Huang S, He T, et al. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Asia Pac J Clin Nutr. 2016;25(3):578-88.
Xie, Y., Huang, S., He, T., & Su, Y. (2016). Coffee consumption and risk of gastric cancer: an updated meta-analysis. Asia Pacific Journal of Clinical Nutrition, 25(3), pp. 578-88. doi:10.6133/apjcn.092015.07.
Xie Y, et al. Coffee Consumption and Risk of Gastric Cancer: an Updated Meta-analysis. Asia Pac J Clin Nutr. 2016;25(3):578-88. PubMed PMID: 27440694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and risk of gastric cancer: an updated meta-analysis. AU - Xie,Yan, AU - Huang,Shifeng, AU - He,Tongchuan, AU - Su,Yuxi, PY - 2016/7/22/entrez PY - 2016/7/22/pubmed PY - 2016/9/14/medline SP - 578 EP - 88 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 25 IS - 3 N2 - BACKGROUND AND OBJECTIVES: Coffee is one of the most widely consumed beverages worldwide, and many studies have investigated the association between coffee consumption and gastric cancer. However, the results are inconsistent. We conducted a systematic analysis of relevant population studies to derive a more precise estimation. METHODS AND STUDY DESIGN: Cochrane library, PubMed and Embase databases were searched to identify studies that met predetermined inclusion criterion through July 2014. All epidemiologic studies regarding coffee consumption and gastric cancer risk were selected, and relative risks (RRs) with 95% confidence intervals (CIs) were calculated. RESULTS: Twenty two studies (9 cohort and 13 case-control studies) involving 7,631 cases and 1,019,693 controls were included. The summary RR of gastric cancer was 0.94 (95% CI: 0.80-1.10) for the highest category of coffee consumption compared with the lowest category, and 0.93 (95% CI: 0.88-0.99) for coffee drinkers compared with nondrinkers. We stratified the population by coffee consumption. The pooled RR for the population with <1 cup/day, 1-2 cups/day and 3-4 cups/day coffee consumption compared with nondrinkers were 0.95 (95% CI: 0.84-1.08), 0.92 (95% CI: 0.82-1.03) and 0.88 (95% CI: 0.76-1.02), respectively, indicating that an increase in coffee consumption was associated with a decreased risk of gastric cancer. Furthermore, we stratified the studies by design, sex, population and time. A significant association between coffee intake and decreased gastric cancer risk was shown in case-control studies (RR=0.85, 95% CI: 0.77-0.95) and among the studies published over the last ten years (RR=0.88, 95% CI: 0.77-1.00). CONCLUSIONS: Our meta-analysis suggested that coffee consumption might be associated with a decreased risk of gastric cancer. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/27440694/full_citation L2 - http://apjcn.nhri.org.tw/server/APJCN/25/3/578.pdf DB - PRIME DP - Unbound Medicine ER -