Tags

Type your tag names separated by a space and hit enter

Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations.
Eur J Pharmacol. 1989 Apr 12; 163(1):77-83.EJ

Abstract

The effect of L-cysteine on the depletion of serotonin and 5-hydroxyindoleacetic acid concentrations caused by p-chloroamphetamine and d-fenfluramine was studied in various brain regions one week after drug injection. p-Chloroamphetamine (2.5 and 5 mg/kg i.p.) and d-fenfluramine (13.4 mg/kg i.p.) significantly reduced serotonin and 5-hydroxyindoleacetic acid levels in the striatum, hippocampus and cortex, particularly in the latter areas. L-cysteine (500 mg/kg i.p.), administered 30 min before and 5 h after p-chloroamphetamine or d-fenfluramine, significantly reduced the effect of either drug on the concentrations of both indoles without causing any effect by itself. In another experiment, the rats were treated as above and were killed at various times after p-chloroamphetamine or d-fenfluramine injection to determine, in parallel, the indole levels in the whole brain and the concentration of p-chloroamphetamine, d-fenfluramine and its metabolite d-norfenfluramine in the plasma and brain. p-Chloroamphetamine and d-fenfluramine markedly lowered both indoles, particularly 16 and 24 h after injection. L-cysteine had no effect on the indole concentrations but significantly reduced the effect of p-chloroamphetamine, d-fenfluramine 16 and 24 h after injection. At these times, the brain concentrations of p-chloroamphetamine, d-fenfluramine and d-norfenfluramine were markedly lower in the L-cysteine-treated than in the control rats. Analysis of the blood concentration of p-chloroamphetamine, d-fenfluramine and d-norfenfluramine showed that the rats treated with L-cysteine eliminated the drugs studied more rapidly than the control animals.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2744095

Citation

Invernizzi, R, et al. "Effect of L-cysteine On the Long-term Depletion of Brain Indoles Caused By P-chloroamphetamine and D-fenfluramine in Rats. Relation to Brain Drug Concentrations." European Journal of Pharmacology, vol. 163, no. 1, 1989, pp. 77-83.
Invernizzi R, Fracasso C, Caccia S, et al. Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations. Eur J Pharmacol. 1989;163(1):77-83.
Invernizzi, R., Fracasso, C., Caccia, S., Di Clemente, A., Garattini, S., & Samanin, R. (1989). Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations. European Journal of Pharmacology, 163(1), 77-83.
Invernizzi R, et al. Effect of L-cysteine On the Long-term Depletion of Brain Indoles Caused By P-chloroamphetamine and D-fenfluramine in Rats. Relation to Brain Drug Concentrations. Eur J Pharmacol. 1989 Apr 12;163(1):77-83. PubMed PMID: 2744095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations. AU - Invernizzi,R, AU - Fracasso,C, AU - Caccia,S, AU - Di Clemente,A, AU - Garattini,S, AU - Samanin,R, PY - 1989/4/12/pubmed PY - 1989/4/12/medline PY - 1989/4/12/entrez SP - 77 EP - 83 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 163 IS - 1 N2 - The effect of L-cysteine on the depletion of serotonin and 5-hydroxyindoleacetic acid concentrations caused by p-chloroamphetamine and d-fenfluramine was studied in various brain regions one week after drug injection. p-Chloroamphetamine (2.5 and 5 mg/kg i.p.) and d-fenfluramine (13.4 mg/kg i.p.) significantly reduced serotonin and 5-hydroxyindoleacetic acid levels in the striatum, hippocampus and cortex, particularly in the latter areas. L-cysteine (500 mg/kg i.p.), administered 30 min before and 5 h after p-chloroamphetamine or d-fenfluramine, significantly reduced the effect of either drug on the concentrations of both indoles without causing any effect by itself. In another experiment, the rats were treated as above and were killed at various times after p-chloroamphetamine or d-fenfluramine injection to determine, in parallel, the indole levels in the whole brain and the concentration of p-chloroamphetamine, d-fenfluramine and its metabolite d-norfenfluramine in the plasma and brain. p-Chloroamphetamine and d-fenfluramine markedly lowered both indoles, particularly 16 and 24 h after injection. L-cysteine had no effect on the indole concentrations but significantly reduced the effect of p-chloroamphetamine, d-fenfluramine 16 and 24 h after injection. At these times, the brain concentrations of p-chloroamphetamine, d-fenfluramine and d-norfenfluramine were markedly lower in the L-cysteine-treated than in the control rats. Analysis of the blood concentration of p-chloroamphetamine, d-fenfluramine and d-norfenfluramine showed that the rats treated with L-cysteine eliminated the drugs studied more rapidly than the control animals.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/2744095/Effect_of_L_cysteine_on_the_long_term_depletion_of_brain_indoles_caused_by_p_chloroamphetamine_and_d_fenfluramine_in_rats__Relation_to_brain_drug_concentrations_ DB - PRIME DP - Unbound Medicine ER -