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Retinal Capillary Network and Foveal Avascular Zone in Eyes with Vein Occlusion and Fellow Eyes Analyzed With Optical Coherence Tomography Angiography.
Invest Ophthalmol Vis Sci. 2016 07 01; 57(9):OCT486-94.IO

Abstract

PURPOSE

To evaluate the perifoveolar retinal capillary network at different depths and to quantify the foveal avascular zone (FAZ) in eyes with retinal vein occlusion (RVO) compared with their fellow eyes and healthy controls using spectral-domain optical coherence tomography angiography (SD-OCTA).

METHODS

We prospectively recruited 23 patients with RVO including 15 eyes with central RVO (CRVO) and 8 eyes with branch RVO (BRVO), their fellow eyes, and 8 age-matched healthy controls (8 eyes) for imaging on prototype OCTA software within RTVue-XR Avanti. The 3 × 3 mm and 6 × 6 mm en face angiograms of superficial and deep retinal capillary plexuses were segmented. Perifoveolar retinal capillary network was analyzed and FAZ was quantified.

RESULTS

Decrease in vascular perfusion at the deep plexus was observed in all eyes with CRVO (8/8, 100%) and BRVO (6/6, 100%) without cystoid macular edema, and in 8 of 15 (53%) and 2 of 8 (25%) of the fellow eyes, respectively. Vascular tortuosity was observed in 13 of 15 (87%) CRVO and 5 of 8 (63%) BRVO eyes. Collaterals were seen in 10 of 15 (67%) CRVO and 5 of 8 (63%) BRVO eyes. Mean FAZ area was larger in eyes with RVO than their fellow eyes (1.13 ± 0.25 mm2 versus 0.58 ± 0.28 mm2; P = 0.007) and controls (1.13 ± 0.25 mm2 versus 0.30 ± 0.09 mm2; P < 0.0001), and in fellow eyes of RVO patients when compared to controls (0.58 ± 0.28 mm2 versus 0.30 ± 0.09 mm2; P = 0.01).

CONCLUSIONS

Spectral-domain OCTA reveals abnormalities at different levels of perifoveolar retinal capillary network and is able to quantify the FAZ in RVO. Longitudinal studies may be considered to evaluate the clinical utility of OCTA in RVO and other retinal vascular diseases.

Authors+Show Affiliations

New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 2Departments of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachu.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 3CAPES Foundation, Ministry of Education of Brazil, Brasilia, Distrito Federal, Brazil.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 3CAPES Foundation, Ministry of Education of Brazil, Brasilia, Distrito Federal, Brazil 4Ophthalmic Center Reference (CEROF), Federal University of Goiás, GoiâDepartment of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 6Doheny Eye Institute, Los Angeles, California, United States.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 2Departments of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachu.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 6Doheny Eye Institute, Los Angeles, California, United States.Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 7Stein Eye Institute, Los Angeles, California, United States 8Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27442342

Citation

Adhi, Mehreen, et al. "Retinal Capillary Network and Foveal Avascular Zone in Eyes With Vein Occlusion and Fellow Eyes Analyzed With Optical Coherence Tomography Angiography." Investigative Ophthalmology & Visual Science, vol. 57, no. 9, 2016, pp. OCT486-94.
Adhi M, Filho MA, Louzada RN, et al. Retinal Capillary Network and Foveal Avascular Zone in Eyes with Vein Occlusion and Fellow Eyes Analyzed With Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016;57(9):OCT486-94.
Adhi, M., Filho, M. A., Louzada, R. N., Kuehlewein, L., de Carlo, T. E., Baumal, C. R., Witkin, A. J., Sadda, S. R., Sarraf, D., Reichel, E., Duker, J. S., & Waheed, N. K. (2016). Retinal Capillary Network and Foveal Avascular Zone in Eyes with Vein Occlusion and Fellow Eyes Analyzed With Optical Coherence Tomography Angiography. Investigative Ophthalmology & Visual Science, 57(9), OCT486-94. https://doi.org/10.1167/iovs.15-18907
Adhi M, et al. Retinal Capillary Network and Foveal Avascular Zone in Eyes With Vein Occlusion and Fellow Eyes Analyzed With Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 07 1;57(9):OCT486-94. PubMed PMID: 27442342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal Capillary Network and Foveal Avascular Zone in Eyes with Vein Occlusion and Fellow Eyes Analyzed With Optical Coherence Tomography Angiography. AU - Adhi,Mehreen, AU - Filho,Marco A Bonini, AU - Louzada,Ricardo N, AU - Kuehlewein,Laura, AU - de Carlo,Talisa E, AU - Baumal,Caroline R, AU - Witkin,Andre J, AU - Sadda,Srinivas R, AU - Sarraf,David, AU - Reichel,Elias, AU - Duker,Jay S, AU - Waheed,Nadia K, PY - 2016/7/22/entrez PY - 2016/7/22/pubmed PY - 2017/6/24/medline SP - OCT486 EP - 94 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 57 IS - 9 N2 - PURPOSE: To evaluate the perifoveolar retinal capillary network at different depths and to quantify the foveal avascular zone (FAZ) in eyes with retinal vein occlusion (RVO) compared with their fellow eyes and healthy controls using spectral-domain optical coherence tomography angiography (SD-OCTA). METHODS: We prospectively recruited 23 patients with RVO including 15 eyes with central RVO (CRVO) and 8 eyes with branch RVO (BRVO), their fellow eyes, and 8 age-matched healthy controls (8 eyes) for imaging on prototype OCTA software within RTVue-XR Avanti. The 3 × 3 mm and 6 × 6 mm en face angiograms of superficial and deep retinal capillary plexuses were segmented. Perifoveolar retinal capillary network was analyzed and FAZ was quantified. RESULTS: Decrease in vascular perfusion at the deep plexus was observed in all eyes with CRVO (8/8, 100%) and BRVO (6/6, 100%) without cystoid macular edema, and in 8 of 15 (53%) and 2 of 8 (25%) of the fellow eyes, respectively. Vascular tortuosity was observed in 13 of 15 (87%) CRVO and 5 of 8 (63%) BRVO eyes. Collaterals were seen in 10 of 15 (67%) CRVO and 5 of 8 (63%) BRVO eyes. Mean FAZ area was larger in eyes with RVO than their fellow eyes (1.13 ± 0.25 mm2 versus 0.58 ± 0.28 mm2; P = 0.007) and controls (1.13 ± 0.25 mm2 versus 0.30 ± 0.09 mm2; P < 0.0001), and in fellow eyes of RVO patients when compared to controls (0.58 ± 0.28 mm2 versus 0.30 ± 0.09 mm2; P = 0.01). CONCLUSIONS: Spectral-domain OCTA reveals abnormalities at different levels of perifoveolar retinal capillary network and is able to quantify the FAZ in RVO. Longitudinal studies may be considered to evaluate the clinical utility of OCTA in RVO and other retinal vascular diseases. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/27442342/Retinal_Capillary_Network_and_Foveal_Avascular_Zone_in_Eyes_with_Vein_Occlusion_and_Fellow_Eyes_Analyzed_With_Optical_Coherence_Tomography_Angiography_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.15-18907 DB - PRIME DP - Unbound Medicine ER -