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Affect of APOE on information processing speed in non-demented elderly population: a preliminary structural MRI study.
Brain Imaging Behav 2017; 11(4):977-985BI

Abstract

APOE is one of the strongest genetic factors associated with information processing speed (IPS). Herein, we explored the neural substrates underlying APOE-related IPS alteration by measuring lobar distribution of white matter hyperintensities (WMH), cortical grey matter volume (GMV) and thickness. Using the ADNI database, we evaluated 178 cognitively normal elderly individuals including 34 APOE ε2 carriers, 54 APOE ε4 carriers and 90 ε3 homozygotes. IPS was determined using Trail Making Tests (TMT). We quantified lobar distribution of WMH, cortical GM lobar volume, cortical thickness among three groups. Finally, we used Pearson's correlation and general linear models to examine structural MRI markers in relation to IPS. There were significant differences of IPS among groups, with ε4 carriers displaying the worst performance. Across groups, significant differences in frontal and parietal WMH load were observed (the highest in ε4 carriers); however, no significant differences in cortical GMV and thickness were found. Pearson's correlation analysis showed parietal WMH volume was significantly related with IPS, especially in ε4 carriers. Subsequently a general linear model demonstrated that parietal WMH volume, age and the interaction between parietal WMH volume and age, was significantly associated with IPS, even after adjusting total intracranial volume (TIV), gender and vascular risk factors. Disruption of WM structure, rather than atrophy of GM, plays a more critical role in APOE ε4 allele-specific IPS. Moreover, specific WMH loci are closely associated with IPS; increased parietal WMH volume, especially in ε4 carriers, was independently contributed to slower IPS.

Authors+Show Affiliations

Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China.Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, China. zhangminming@zju.edu.cn.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27444731

Citation

Luo, Xiao, et al. "Affect of APOE On Information Processing Speed in Non-demented Elderly Population: a Preliminary Structural MRI Study." Brain Imaging and Behavior, vol. 11, no. 4, 2017, pp. 977-985.
Luo X, Jiaerken Y, Yu X, et al. Affect of APOE on information processing speed in non-demented elderly population: a preliminary structural MRI study. Brain Imaging Behav. 2017;11(4):977-985.
Luo, X., Jiaerken, Y., Yu, X., Huang, P., Qiu, T., Jia, Y., ... Zhang, M. (2017). Affect of APOE on information processing speed in non-demented elderly population: a preliminary structural MRI study. Brain Imaging and Behavior, 11(4), pp. 977-985. doi:10.1007/s11682-016-9571-0.
Luo X, et al. Affect of APOE On Information Processing Speed in Non-demented Elderly Population: a Preliminary Structural MRI Study. Brain Imaging Behav. 2017;11(4):977-985. PubMed PMID: 27444731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Affect of APOE on information processing speed in non-demented elderly population: a preliminary structural MRI study. AU - Luo,Xiao, AU - Jiaerken,Yerfan, AU - Yu,Xinfeng, AU - Huang,Peiyu, AU - Qiu,Tiantian, AU - Jia,Yunlu, AU - Sun,Jianzhong, AU - Zhou,Jiong, AU - Zhang,Minming, AU - ,, PY - 2016/7/23/pubmed PY - 2018/8/28/medline PY - 2016/7/23/entrez KW - APOE KW - Information processing speed KW - Surface-based analysis KW - Voxel-based morphometry (VBM) KW - White matter hyperintensities SP - 977 EP - 985 JF - Brain imaging and behavior JO - Brain Imaging Behav VL - 11 IS - 4 N2 - APOE is one of the strongest genetic factors associated with information processing speed (IPS). Herein, we explored the neural substrates underlying APOE-related IPS alteration by measuring lobar distribution of white matter hyperintensities (WMH), cortical grey matter volume (GMV) and thickness. Using the ADNI database, we evaluated 178 cognitively normal elderly individuals including 34 APOE ε2 carriers, 54 APOE ε4 carriers and 90 ε3 homozygotes. IPS was determined using Trail Making Tests (TMT). We quantified lobar distribution of WMH, cortical GM lobar volume, cortical thickness among three groups. Finally, we used Pearson's correlation and general linear models to examine structural MRI markers in relation to IPS. There were significant differences of IPS among groups, with ε4 carriers displaying the worst performance. Across groups, significant differences in frontal and parietal WMH load were observed (the highest in ε4 carriers); however, no significant differences in cortical GMV and thickness were found. Pearson's correlation analysis showed parietal WMH volume was significantly related with IPS, especially in ε4 carriers. Subsequently a general linear model demonstrated that parietal WMH volume, age and the interaction between parietal WMH volume and age, was significantly associated with IPS, even after adjusting total intracranial volume (TIV), gender and vascular risk factors. Disruption of WM structure, rather than atrophy of GM, plays a more critical role in APOE ε4 allele-specific IPS. Moreover, specific WMH loci are closely associated with IPS; increased parietal WMH volume, especially in ε4 carriers, was independently contributed to slower IPS. SN - 1931-7565 UR - https://www.unboundmedicine.com/medline/citation/27444731/Affect_of_APOE_on_information_processing_speed_in_non_demented_elderly_population:_a_preliminary_structural_MRI_study_ L2 - https://dx.doi.org/10.1007/s11682-016-9571-0 DB - PRIME DP - Unbound Medicine ER -