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The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study.
Exp Ther Med. 2016 Aug; 12(2):739-745.ET

Abstract

The aim of the present study was to determine whether hyaluronic acid (HA) or physical therapy agents (PTA) can improve functional parameters in patients with knee Kashin-Beck disease (KBD). For 2 years, patients (n=55) were treated with HA weekly for 5 weeks, then received 6th and 7th injections on the 3rd and 6th month, respectively, for 7 injections in total. Patients (n=53) were treated with PTA five times a week for 3 weeks every month for 6 months. The patients were evaluated with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the visual analog pain scale (VAS). Trial registration, ChiCTR-TRC-12002189 (http://www.chictr.org/). During the study, following treatment interruption, pain increased in the PTA group (from a mean value of 85.7±83.8 mm at month 12 to 145.2±128.8 mm at month 18 and 201.3±150.5 mm at month 24), while it remained stable in the HA group (from a mean value of 80.7±70.6 mm at month 12 to 90.1±95.2 mm at month 18 and 82.6±85.3 mm at month 24), with a statistically significant difference in favor of HA at month 18 (P<0.05) and month 24 (P<0.05). Joint stiffness, physical function and total WOMAC showed the same trend as pain. The global efficacy judgments by the patients and the investigators showed a statistically significant difference in favor of HA at month 18 (P<0.05) and month 24 (P<0.05). In conclusion, although all the patients improved in terms of pain and function, HA was superior to PTA alone for pain relief and lasting effect.

Authors+Show Affiliations

Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.Department of Public Health, Medical College, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi 710061, P.R. China.Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.Xi'an Red Cross Hospital, Xi'an, Shaanxi 710061, P.R. China.Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27446269

Citation

Yang, Pinglin, et al. "The Efficacy and Safety of Intra-articular Injection of Hyaluronic Acid in the Knee and Physical Therapy Agents to Treat Kashin-Beck Disease: a Prospective Interventional Study." Experimental and Therapeutic Medicine, vol. 12, no. 2, 2016, pp. 739-745.
Yang P, Guo X, He X, et al. The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study. Exp Ther Med. 2016;12(2):739-745.
Yang, P., Guo, X., He, X., Zang, Q., Wang, G., Xu, P., & Wang, W. (2016). The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study. Experimental and Therapeutic Medicine, 12(2), 739-745.
Yang P, et al. The Efficacy and Safety of Intra-articular Injection of Hyaluronic Acid in the Knee and Physical Therapy Agents to Treat Kashin-Beck Disease: a Prospective Interventional Study. Exp Ther Med. 2016;12(2):739-745. PubMed PMID: 27446269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study. AU - Yang,Pinglin, AU - Guo,Xiong, AU - He,Xijing, AU - Zang,Quanjin, AU - Wang,Guoyu, AU - Xu,Peng, AU - Wang,Weizhuo, Y1 - 2016/05/19/ PY - 2015/12/17/received PY - 2016/05/13/accepted PY - 2016/7/23/entrez PY - 2016/7/23/pubmed PY - 2016/7/23/medline KW - Kashin-Beck disease KW - hyaluronic acid SP - 739 EP - 745 JF - Experimental and therapeutic medicine JO - Exp Ther Med VL - 12 IS - 2 N2 - The aim of the present study was to determine whether hyaluronic acid (HA) or physical therapy agents (PTA) can improve functional parameters in patients with knee Kashin-Beck disease (KBD). For 2 years, patients (n=55) were treated with HA weekly for 5 weeks, then received 6th and 7th injections on the 3rd and 6th month, respectively, for 7 injections in total. Patients (n=53) were treated with PTA five times a week for 3 weeks every month for 6 months. The patients were evaluated with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the visual analog pain scale (VAS). Trial registration, ChiCTR-TRC-12002189 (http://www.chictr.org/). During the study, following treatment interruption, pain increased in the PTA group (from a mean value of 85.7±83.8 mm at month 12 to 145.2±128.8 mm at month 18 and 201.3±150.5 mm at month 24), while it remained stable in the HA group (from a mean value of 80.7±70.6 mm at month 12 to 90.1±95.2 mm at month 18 and 82.6±85.3 mm at month 24), with a statistically significant difference in favor of HA at month 18 (P<0.05) and month 24 (P<0.05). Joint stiffness, physical function and total WOMAC showed the same trend as pain. The global efficacy judgments by the patients and the investigators showed a statistically significant difference in favor of HA at month 18 (P<0.05) and month 24 (P<0.05). In conclusion, although all the patients improved in terms of pain and function, HA was superior to PTA alone for pain relief and lasting effect. SN - 1792-0981 UR - https://www.unboundmedicine.com/medline/citation/27446269/The_efficacy_and_safety_of_intra_articular_injection_of_hyaluronic_acid_in_the_knee_and_physical_therapy_agents_to_treat_Kashin_Beck_disease:_A_prospective_interventional_study_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=1792-0981&amp;volume=12&amp;issue=2&amp;spage=739&amp;aulast=Yang DB - PRIME DP - Unbound Medicine ER -
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