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Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis.
Chem Biodivers 2016; 13(11):1537-1550CB

Abstract

The essential oil compositions of the leaves of three related Myrtaceae species, namely Syzygium aqueum, Syzygium samarangense and Eugenia uniflora, were investigated using GLC/MS and GLC/FID. Altogether, 125 compounds were identified: α-Selinene (13.85%), β-caryophyllene (12.72%) and β-selinene constitute the most abundant constituents in S. aqueum. Germacrene D (21.62%) represents the major compound in S. samarangense whereas in E. uniflora, spathulenol (15.80%) represents the predominant component. Multivariate chemometric analyses were used to discriminate the essential oils using hierarchical cluster analysis (HCA) and principal component analysis (PCA) based on the chromatographic results. The antimicrobial activity of the popularly used E. uniflora essential oil was assessed using broth microdilution method against six Gram-positive, three Gram-negative bacteria and two fungi. The oil showed moderate antimicrobial activity against Bacillus licheniformis exhibiting MIC and MMC of 0.63 mg/ml. The cytotoxic activity of E. uniflora essential oil was investigated against Trypanosoma brucei brucei (T. b. brucei) and MCF-7 cancer cell line using MTT assay. It showed moderate activity against MCF-7 cells with an IC50 value of 76.40 μg/ml. On the other hand, T. brucei was highly susceptible to E. uniflora essential oil with IC50 of 11.20 μg/ml, and a selectivity index of 6.82.

Authors+Show Affiliations

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, DE-69120, Heidelberg, Germany.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, DE-69120, Heidelberg, Germany.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, DE-69120, Heidelberg, Germany.Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University Abbassia, 11566, Cairo, Egypt.Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University Abbassia, 11566, Cairo, Egypt.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, DE-69120, Heidelberg, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27447784

Citation

Sobeh, Mansour, et al. "Chemical Profiling of the Essential Oils of Syzygium Aqueum, Syzygium Samarangense and Eugenia Uniflora and Their Discrimination Using Chemometric Analysis." Chemistry & Biodiversity, vol. 13, no. 11, 2016, pp. 1537-1550.
Sobeh M, Braun MS, Krstin S, et al. Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis. Chem Biodivers. 2016;13(11):1537-1550.
Sobeh, M., Braun, M. S., Krstin, S., Youssef, F. S., Ashour, M. L., & Wink, M. (2016). Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis. Chemistry & Biodiversity, 13(11), pp. 1537-1550. doi:10.1002/cbdv.201600089.
Sobeh M, et al. Chemical Profiling of the Essential Oils of Syzygium Aqueum, Syzygium Samarangense and Eugenia Uniflora and Their Discrimination Using Chemometric Analysis. Chem Biodivers. 2016;13(11):1537-1550. PubMed PMID: 27447784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis. AU - Sobeh,Mansour, AU - Braun,Markus Santhosh, AU - Krstin,Sonja, AU - Youssef,Fadia S, AU - Ashour,Mohamed L, AU - Wink,Michael, Y1 - 2016/11/02/ PY - 2016/03/14/received PY - 2016/06/03/accepted PY - 2016/11/3/pubmed PY - 2017/1/18/medline PY - 2016/7/23/entrez KW - Biological activity KW - Chemical composition KW - Multivariate chemometric analysis KW - Myrtaceae KW - Volatile oils SP - 1537 EP - 1550 JF - Chemistry & biodiversity JO - Chem. Biodivers. VL - 13 IS - 11 N2 - The essential oil compositions of the leaves of three related Myrtaceae species, namely Syzygium aqueum, Syzygium samarangense and Eugenia uniflora, were investigated using GLC/MS and GLC/FID. Altogether, 125 compounds were identified: α-Selinene (13.85%), β-caryophyllene (12.72%) and β-selinene constitute the most abundant constituents in S. aqueum. Germacrene D (21.62%) represents the major compound in S. samarangense whereas in E. uniflora, spathulenol (15.80%) represents the predominant component. Multivariate chemometric analyses were used to discriminate the essential oils using hierarchical cluster analysis (HCA) and principal component analysis (PCA) based on the chromatographic results. The antimicrobial activity of the popularly used E. uniflora essential oil was assessed using broth microdilution method against six Gram-positive, three Gram-negative bacteria and two fungi. The oil showed moderate antimicrobial activity against Bacillus licheniformis exhibiting MIC and MMC of 0.63 mg/ml. The cytotoxic activity of E. uniflora essential oil was investigated against Trypanosoma brucei brucei (T. b. brucei) and MCF-7 cancer cell line using MTT assay. It showed moderate activity against MCF-7 cells with an IC50 value of 76.40 μg/ml. On the other hand, T. brucei was highly susceptible to E. uniflora essential oil with IC50 of 11.20 μg/ml, and a selectivity index of 6.82. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/27447784/Chemical_Profiling_of_the_Essential_Oils_of_Syzygium_aqueum_Syzygium_samarangense_and_Eugenia_uniflora_and_Their_Discrimination_Using_Chemometric_Analysis_ L2 - https://doi.org/10.1002/cbdv.201600089 DB - PRIME DP - Unbound Medicine ER -