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Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women.
Environ Res. 2016 Nov; 151:30-37.ER

Abstract

INTRODUCTION

Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the prospective cohort, "Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)".

METHODS

Urinary exposure biomarkers (bisphenol A, triclosan, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, butyl, methyl and propyl paraben) and serum hormone levels (estradiol, progesterone, sex hormone-binding globulin (SHBG), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone) were measured at up to two time points during pregnancy (16-20 weeks and 24-28 weeks). We used linear mixed models to assess relationships between exposure biomarkers and hormone levels across pregnancy, controlling for urinary specific gravity, maternal age, BMI and education. In sensitivity analyses, we evaluated cross-sectional relationships between exposure and hormone levels stratified by study visit using linear regression.

RESULTS

An IQR increase in methyl paraben was associated with a 7.70% increase (95% CI 1.50, 13.90) in SHBG. Furthermore, an IQR increase in butyl paraben as associated with an 8.46% decrease (95% CI 16.92, 0.00) in estradiol, as well as a 9.34% decrease (95% CI -18.31,-0.38) in estradiol/progesterone. Conversely, an IQR increase in butyl paraben was associated with a 5.64% increase (95% CI 1.26, 10.02) in FT4. Progesterone was consistently negatively associated with phenols, but none reached statistical significance. After stratification, methyl and propyl paraben were suggestively negatively associated with estradiol at the first time point (16-20 weeks), and suggestively positively associated with estradiol at the second time point (24-28 weeks).

CONCLUSIONS

Within this ongoing birth cohort, certain phenols and parabens were associated with altered reproductive and thyroid hormone levels during pregnancy. These changes may contribute to adverse health effects in mothers or their offspring, but additional research is required.

Authors+Show Affiliations

Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Medicine, Georgetown University, 3900 Reservoir Rd NW, Washington, DC 20007, USA.University of Puerto Rico Graduate School of Public Health, UPR Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-5067, USA.College of Engineering, Northeastern University, 110 Forsyth St, Boston, MA 02115, USA.University of Puerto Rico Graduate School of Public Health, UPR Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-5067, USA.Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA. Electronic address: meekerj@umich.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27448730

Citation

Aker, Amira M., et al. "Phenols and Parabens in Relation to Reproductive and Thyroid Hormones in Pregnant Women." Environmental Research, vol. 151, 2016, pp. 30-37.
Aker AM, Watkins DJ, Johns LE, et al. Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women. Environ Res. 2016;151:30-37.
Aker, A. M., Watkins, D. J., Johns, L. E., Ferguson, K. K., Soldin, O. P., Anzalota Del Toro, L. V., Alshawabkeh, A. N., Cordero, J. F., & Meeker, J. D. (2016). Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women. Environmental Research, 151, 30-37. https://doi.org/10.1016/j.envres.2016.07.002
Aker AM, et al. Phenols and Parabens in Relation to Reproductive and Thyroid Hormones in Pregnant Women. Environ Res. 2016;151:30-37. PubMed PMID: 27448730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women. AU - Aker,Amira M, AU - Watkins,Deborah J, AU - Johns,Lauren E, AU - Ferguson,Kelly K, AU - Soldin,Offie P, AU - Anzalota Del Toro,Liza V, AU - Alshawabkeh,Akram N, AU - Cordero,José F, AU - Meeker,John D, Y1 - 2016/07/21/ PY - 2016/03/23/received PY - 2016/05/31/revised PY - 2016/07/02/accepted PY - 2016/10/21/pubmed PY - 2017/5/2/medline PY - 2016/7/25/entrez KW - Parabens KW - Phenols KW - Pregnancy KW - Reproductive hormones KW - Thyroid hormones SP - 30 EP - 37 JF - Environmental research JO - Environ. Res. VL - 151 N2 - INTRODUCTION: Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the prospective cohort, "Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)". METHODS: Urinary exposure biomarkers (bisphenol A, triclosan, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, butyl, methyl and propyl paraben) and serum hormone levels (estradiol, progesterone, sex hormone-binding globulin (SHBG), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone) were measured at up to two time points during pregnancy (16-20 weeks and 24-28 weeks). We used linear mixed models to assess relationships between exposure biomarkers and hormone levels across pregnancy, controlling for urinary specific gravity, maternal age, BMI and education. In sensitivity analyses, we evaluated cross-sectional relationships between exposure and hormone levels stratified by study visit using linear regression. RESULTS: An IQR increase in methyl paraben was associated with a 7.70% increase (95% CI 1.50, 13.90) in SHBG. Furthermore, an IQR increase in butyl paraben as associated with an 8.46% decrease (95% CI 16.92, 0.00) in estradiol, as well as a 9.34% decrease (95% CI -18.31,-0.38) in estradiol/progesterone. Conversely, an IQR increase in butyl paraben was associated with a 5.64% increase (95% CI 1.26, 10.02) in FT4. Progesterone was consistently negatively associated with phenols, but none reached statistical significance. After stratification, methyl and propyl paraben were suggestively negatively associated with estradiol at the first time point (16-20 weeks), and suggestively positively associated with estradiol at the second time point (24-28 weeks). CONCLUSIONS: Within this ongoing birth cohort, certain phenols and parabens were associated with altered reproductive and thyroid hormone levels during pregnancy. These changes may contribute to adverse health effects in mothers or their offspring, but additional research is required. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/27448730/Phenols_and_parabens_in_relation_to_reproductive_and_thyroid_hormones_in_pregnant_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(16)30284-5 DB - PRIME DP - Unbound Medicine ER -