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Motor effects of locally administered pinaverium bromide in the sigmoid tract of patients with irritable bowel syndrome.
Int J Clin Pharmacol Ther Toxicol. 1989 Jan; 27(1):47-50.IJ

Abstract

The effects of pinaverium bromide, a non-absorbable antispasmodic agent, administered locally, on sigmoid-rectal motility was investigated in 20 patients with irritable bowel syndrome. The influence of either pinaverium (10 subjects) or placebo (10 subjects) on a neostigmine-induced increase of sigmoid pressure was assessed and compared by means of computerized electromanometry. The drug was found to counteract significantly the motor effects of neostigmine, thus appearing to be an effective compound for the treatment of functional disorders of the colon.

Authors+Show Affiliations

Passaretti S
Gastroenterology Unit, University of Milan, Italy.
Sorghi M
No affiliation info available
Colombo E
No affiliation info available
Mazzotti G
No affiliation info available
Tittobello A
No affiliation info available
Guslandi M
No affiliation info available

MeSH

AdultColon, SigmoidColonic Diseases, FunctionalDrug EvaluationFemaleGastrointestinal MotilityHumansMaleMiddle AgedMorpholinesMotor ActivityParasympatholytics

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2744907

Citation

Passaretti, S, et al. "Motor Effects of Locally Administered Pinaverium Bromide in the Sigmoid Tract of Patients With Irritable Bowel Syndrome." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 27, no. 1, 1989, pp. 47-50.
Passaretti S, Sorghi M, Colombo E, et al. Motor effects of locally administered pinaverium bromide in the sigmoid tract of patients with irritable bowel syndrome. Int J Clin Pharmacol Ther Toxicol. 1989;27(1):47-50.
Passaretti, S., Sorghi, M., Colombo, E., Mazzotti, G., Tittobello, A., & Guslandi, M. (1989). Motor effects of locally administered pinaverium bromide in the sigmoid tract of patients with irritable bowel syndrome. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 27(1), 47-50.
Passaretti S, et al. Motor Effects of Locally Administered Pinaverium Bromide in the Sigmoid Tract of Patients With Irritable Bowel Syndrome. Int J Clin Pharmacol Ther Toxicol. 1989;27(1):47-50. PubMed PMID: 2744907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor effects of locally administered pinaverium bromide in the sigmoid tract of patients with irritable bowel syndrome. AU - Passaretti,S, AU - Sorghi,M, AU - Colombo,E, AU - Mazzotti,G, AU - Tittobello,A, AU - Guslandi,M, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 47 EP - 50 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 27 IS - 1 N2 - The effects of pinaverium bromide, a non-absorbable antispasmodic agent, administered locally, on sigmoid-rectal motility was investigated in 20 patients with irritable bowel syndrome. The influence of either pinaverium (10 subjects) or placebo (10 subjects) on a neostigmine-induced increase of sigmoid pressure was assessed and compared by means of computerized electromanometry. The drug was found to counteract significantly the motor effects of neostigmine, thus appearing to be an effective compound for the treatment of functional disorders of the colon. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/2744907/Motor_effects_of_locally_administered_pinaverium_bromide_in_the_sigmoid_tract_of_patients_with_irritable_bowel_syndrome_ L2 - http://www.diseaseinfosearch.org/result/3876 DB - PRIME DP - Unbound Medicine ER -