Tags

Type your tag names separated by a space and hit enter

Comparison of minocycline and azithromycin for the treatment of mild scrub typhus in northern China.
Int J Antimicrob Agents. 2016 Sep; 48(3):317-20.IJ

Abstract

Scrub typhus, caused by Orientia tsutsugamushi, has recently emerged in northern China where the disease had not been known to exist. Although doxycycline and azithromycin are the recommended agents for the treatment of scrub typhus, clinical responses depend both on the susceptibilities of various O. tsutsugamushi strains and the severity of the disease. A retrospective analysis was conducted on patients diagnosed with mild scrub typhus from August 2013 to January 2016 in the Affiliated Hospital of Nantong University, northern China. A total of 40 patients who received minocycline treatment and 34 patients who received azithromycin treatment were included in the analysis. All patients except one defervesced within 120 h after initiating antimicrobial therapy. Kaplan-Meier curves in association with log-rank test showed that the median time to defervescence was significantly shorter for the minocycline-treated group than the azithromycin-treated group (P = 0.003). There were no serious adverse events during treatment. No relapse occurred in either group during the 1-month follow-up period. In conclusion, both minocycline and azithromycin are effective and safe for the treatment of mild scrub typhus, but minocycline is more active than azithromycin against O. tsutsugamushi infection acquired in northern China.

Authors+Show Affiliations

Department of Emergency Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu 226001, China.Department of Emergency Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu 226001, China.Department of Emergency Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu 226001, China.BDM Consulting Inc., 100 Franklin Square Drive, Suite 102, Somerset, NJ 08873, USA.Waksman Institute of Microbiology, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA.Department of Emergency Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu 226001, China. Electronic address: yanboshen123@163.com.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27449540

Citation

Zhao, Minxing, et al. "Comparison of Minocycline and Azithromycin for the Treatment of Mild Scrub Typhus in Northern China." International Journal of Antimicrobial Agents, vol. 48, no. 3, 2016, pp. 317-20.
Zhao M, Wang T, Yuan X, et al. Comparison of minocycline and azithromycin for the treatment of mild scrub typhus in northern China. Int J Antimicrob Agents. 2016;48(3):317-20.
Zhao, M., Wang, T., Yuan, X., Du, W., Lin, M., & Shen, Y. (2016). Comparison of minocycline and azithromycin for the treatment of mild scrub typhus in northern China. International Journal of Antimicrobial Agents, 48(3), 317-20. https://doi.org/10.1016/j.ijantimicag.2016.05.019
Zhao M, et al. Comparison of Minocycline and Azithromycin for the Treatment of Mild Scrub Typhus in Northern China. Int J Antimicrob Agents. 2016;48(3):317-20. PubMed PMID: 27449540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of minocycline and azithromycin for the treatment of mild scrub typhus in northern China. AU - Zhao,Minxing, AU - Wang,Ting, AU - Yuan,Xiaoyu, AU - Du,Weiming, AU - Lin,Miaoxin, AU - Shen,Yanbo, Y1 - 2016/07/12/ PY - 2016/03/30/received PY - 2016/05/24/revised PY - 2016/05/28/accepted PY - 2016/7/25/entrez PY - 2016/7/28/pubmed PY - 2017/3/7/medline KW - Azithromycin KW - Doxycycline KW - Minocycline KW - Northern China KW - Scrub typhus KW - Tetracycline SP - 317 EP - 20 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 48 IS - 3 N2 - Scrub typhus, caused by Orientia tsutsugamushi, has recently emerged in northern China where the disease had not been known to exist. Although doxycycline and azithromycin are the recommended agents for the treatment of scrub typhus, clinical responses depend both on the susceptibilities of various O. tsutsugamushi strains and the severity of the disease. A retrospective analysis was conducted on patients diagnosed with mild scrub typhus from August 2013 to January 2016 in the Affiliated Hospital of Nantong University, northern China. A total of 40 patients who received minocycline treatment and 34 patients who received azithromycin treatment were included in the analysis. All patients except one defervesced within 120 h after initiating antimicrobial therapy. Kaplan-Meier curves in association with log-rank test showed that the median time to defervescence was significantly shorter for the minocycline-treated group than the azithromycin-treated group (P = 0.003). There were no serious adverse events during treatment. No relapse occurred in either group during the 1-month follow-up period. In conclusion, both minocycline and azithromycin are effective and safe for the treatment of mild scrub typhus, but minocycline is more active than azithromycin against O. tsutsugamushi infection acquired in northern China. SN - 1872-7913 UR - https://www.unboundmedicine.com/medline/citation/27449540/Comparison_of_minocycline_and_azithromycin_for_the_treatment_of_mild_scrub_typhus_in_northern_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(16)30160-1 DB - PRIME DP - Unbound Medicine ER -