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Effect of caffeine on ornithine metabolism in rat brain, liver and kidney.
Ital J Biochem. 1989 Mar-Apr; 38(2):75-82.IJ

Abstract

Prolonged treatment with caffeine promotes in rats an increase of liver ornithine carbamyltransferase activity (14-day treatment). In contrast, arginase activity is already reduced in brain and kidney after 10 days, and in the liver much later (17 days). Ornithine transaminase activity was increased in both liver and kidney, while in the brain it was reduced (17 days). Ornithine decarboxylase activity showed only minor modifications in kidney, while it was unchanged in brain. Of the polyamines, only spermidine was significantly modified, being increased in brain, decreased in liver and kidney. Although these results do not explain the mechanism of the modification of brain arginine and ornithine concentration promoted by caffeine, they point to further marked effects, i.e. on OAT activity and on spermidine concentration, which could have a relevant metabolic role.

Authors+Show Affiliations

Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2745038

Citation

Colombatto, S, et al. "Effect of Caffeine On Ornithine Metabolism in Rat Brain, Liver and Kidney." The Italian Journal of Biochemistry, vol. 38, no. 2, 1989, pp. 75-82.
Colombatto S, Fasulo L, Mondardini A, et al. Effect of caffeine on ornithine metabolism in rat brain, liver and kidney. Ital J Biochem. 1989;38(2):75-82.
Colombatto, S., Fasulo, L., Mondardini, A., Malabaila, A., & Grillo, M. A. (1989). Effect of caffeine on ornithine metabolism in rat brain, liver and kidney. The Italian Journal of Biochemistry, 38(2), 75-82.
Colombatto S, et al. Effect of Caffeine On Ornithine Metabolism in Rat Brain, Liver and Kidney. Ital J Biochem. 1989 Mar-Apr;38(2):75-82. PubMed PMID: 2745038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of caffeine on ornithine metabolism in rat brain, liver and kidney. AU - Colombatto,S, AU - Fasulo,L, AU - Mondardini,A, AU - Malabaila,A, AU - Grillo,M A, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 75 EP - 82 JF - The Italian journal of biochemistry JO - Ital J Biochem VL - 38 IS - 2 N2 - Prolonged treatment with caffeine promotes in rats an increase of liver ornithine carbamyltransferase activity (14-day treatment). In contrast, arginase activity is already reduced in brain and kidney after 10 days, and in the liver much later (17 days). Ornithine transaminase activity was increased in both liver and kidney, while in the brain it was reduced (17 days). Ornithine decarboxylase activity showed only minor modifications in kidney, while it was unchanged in brain. Of the polyamines, only spermidine was significantly modified, being increased in brain, decreased in liver and kidney. Although these results do not explain the mechanism of the modification of brain arginine and ornithine concentration promoted by caffeine, they point to further marked effects, i.e. on OAT activity and on spermidine concentration, which could have a relevant metabolic role. SN - 0021-2938 UR - https://www.unboundmedicine.com/medline/citation/2745038/Effect_of_caffeine_on_ornithine_metabolism_in_rat_brain_liver_and_kidney_ L2 - https://medlineplus.gov/caffeine.html DB - PRIME DP - Unbound Medicine ER -