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Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.
Colloids Surf B Biointerfaces. 2016 Oct 01; 146:841-51.CS

Abstract

This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM. XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5μm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5nC/g for untreated material and -7.5 versus 3.1nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1-0.3nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

Authors+Show Affiliations

Department of Pharmacy, University of Huddersfield, Huddersfield, HD1 3DH, UK.School of Pharmacy, University of Wolverhampton, Faculty of Science and Engineering, Wolverhampton, WV1 1LY, UK.The Wolfson Centre for Bulk Solids Handling Technology, Medway School of Engineering, University of Greenwich, Kent, UK.Medway School of Pharmacy, Universities of Kent, Central Avenue, Kent, ME4 4TB, UK.School of Life Sciences, University of Sussex, Arundel Building, Falmer, Brighton, BN1 9QJ, UK; Drug Applied Research Center and Faculty of Pharmacy, Tabriz Medical Sciences University, Tabriz, Iran.Department of Pharmacy, University of Huddersfield, Huddersfield, HD1 3DH, UK.Department of Pharmacy, University of Huddersfield, Huddersfield, HD1 3DH, UK. Electronic address: k.asare-addo@hud.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27451373

Citation

Adebisi, Adeola O., et al. "Solid-state, Triboelectrostatic and Dissolution Characteristics of Spray-dried Piroxicam-glucosamine Solid Dispersions." Colloids and Surfaces. B, Biointerfaces, vol. 146, 2016, pp. 841-51.
Adebisi AO, Kaialy W, Hussain T, et al. Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions. Colloids Surf B Biointerfaces. 2016;146:841-51.
Adebisi, A. O., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. R., & Asare-Addo, K. (2016). Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions. Colloids and Surfaces. B, Biointerfaces, 146, 841-51. https://doi.org/10.1016/j.colsurfb.2016.07.032
Adebisi AO, et al. Solid-state, Triboelectrostatic and Dissolution Characteristics of Spray-dried Piroxicam-glucosamine Solid Dispersions. Colloids Surf B Biointerfaces. 2016 Oct 1;146:841-51. PubMed PMID: 27451373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions. AU - Adebisi,Adeola O, AU - Kaialy,Waseem, AU - Hussain,Tariq, AU - Al-Hamidi,Hiba, AU - Nokhodchi,Ali, AU - Conway,Barbara R, AU - Asare-Addo,Kofi, Y1 - 2016/07/16/ PY - 2016/03/23/received PY - 2016/07/11/revised PY - 2016/07/14/accepted PY - 2016/7/25/entrez PY - 2016/7/28/pubmed PY - 2017/2/22/medline KW - Dissolution KW - Electrostatics KW - Piroxicam KW - Solid dispersions KW - Spray drying KW - d-Glucosamine HCl SP - 841 EP - 51 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 146 N2 - This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM. XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5μm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5nC/g for untreated material and -7.5 versus 3.1nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1-0.3nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/27451373/Solid_state_triboelectrostatic_and_dissolution_characteristics_of_spray_dried_piroxicam_glucosamine_solid_dispersions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(16)30534-3 DB - PRIME DP - Unbound Medicine ER -