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Systematic review and meta-analysis on the prevalence of vitamin D deficiency in patients with chronic pancreatitis.
Pancreatology. 2016 Sep-Oct; 16(5):800-6.P

Abstract

BACKGROUND/OBJECTIVES

Patients with chronic pancreatitis (CP) are at risk of malnutrition due to malabsorption, pain and/or alcohol consumption. This can cause vitamin D insufficiency or deficiency, which is associated with osteoporosis and increased risks of fractures. We aimed to perform a meta-analysis to determine the prevalence of vitamin D insufficiency and deficiency in CP patients. Furthermore, we compared these results with healthy controls.

METHODS

We performed a systematic review and meta-analysis on the literature by searching PubMed and EMBASE (January 2000-December 2015) on CP and vitamin D. Primary outcome was prevalence of vitamin D insufficiency (<75 nmoL/L) and deficiency (<50 nmoL/L) in CP patients. When available, data of CP patients were compared with healthy controls.

RESULTS

Nine studies were included in our meta-analysis, reporting on the prevalence of vitamin D insufficiency/deficiency in 465 patients (mean age 41 years (range 18-60), 81% male) and in 378 controls (mean age 40 years (range 18-67), 76% male). Pooled prevalence of vitamin D insufficiency and deficiency in CP patients was 83% and 65%, respectively. Calculated odds ratio (OR) of vitamin D insufficiency and deficiency between CP patients and controls was 1.34 (0.54-3.29) and 1.14 (0.70-1.85), respectively (p > 0.05).

CONCLUSION

There is a high prevalence of vitamin D insufficiency and deficiency in CP patients. Nevertheless, there is no significant difference in prevalence of vitamin D insufficiency and deficiency compared to healthy controls. Further research should indicate the clinical relevance and consequences of these findings for clinical practice.

Authors+Show Affiliations

Academic Medical Center Amsterdam, Department of Gastroenterology & Hepatology, Netherlands.Academic Medical Center Amsterdam, Department of Gastroenterology & Hepatology, Netherlands.Academic Medical Center Amsterdam, Department of Gastroenterology & Hepatology, Netherlands.Academic Medical Center Amsterdam, Department of Surgery, Netherlands.Academic Medical Center Amsterdam, Department of Gastroenterology & Hepatology, Netherlands. Electronic address: j.e.vanhooft@amc.nl.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27453461

Citation

Hoogenboom, S A., et al. "Systematic Review and Meta-analysis On the Prevalence of Vitamin D Deficiency in Patients With Chronic Pancreatitis." Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], vol. 16, no. 5, 2016, pp. 800-6.
Hoogenboom SA, Lekkerkerker SJ, Fockens P, et al. Systematic review and meta-analysis on the prevalence of vitamin D deficiency in patients with chronic pancreatitis. Pancreatology. 2016;16(5):800-6.
Hoogenboom, S. A., Lekkerkerker, S. J., Fockens, P., Boermeester, M. A., & van Hooft, J. E. (2016). Systematic review and meta-analysis on the prevalence of vitamin D deficiency in patients with chronic pancreatitis. Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], 16(5), 800-6. https://doi.org/10.1016/j.pan.2016.07.010
Hoogenboom SA, et al. Systematic Review and Meta-analysis On the Prevalence of Vitamin D Deficiency in Patients With Chronic Pancreatitis. Pancreatology. 2016 Sep-Oct;16(5):800-6. PubMed PMID: 27453461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review and meta-analysis on the prevalence of vitamin D deficiency in patients with chronic pancreatitis. AU - Hoogenboom,S A, AU - Lekkerkerker,S J, AU - Fockens,P, AU - Boermeester,M A, AU - van Hooft,J E, Y1 - 2016/07/18/ PY - 2016/04/04/received PY - 2016/07/13/revised PY - 2016/07/14/accepted PY - 2016/7/26/entrez PY - 2016/7/28/pubmed PY - 2017/3/28/medline KW - Chronic pancreatitis KW - Exocrine pancreatic insufficiency KW - Prevalence KW - Systematic review KW - Vitamin D deficiency SP - 800 EP - 6 JF - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] JO - Pancreatology VL - 16 IS - 5 N2 - BACKGROUND/OBJECTIVES: Patients with chronic pancreatitis (CP) are at risk of malnutrition due to malabsorption, pain and/or alcohol consumption. This can cause vitamin D insufficiency or deficiency, which is associated with osteoporosis and increased risks of fractures. We aimed to perform a meta-analysis to determine the prevalence of vitamin D insufficiency and deficiency in CP patients. Furthermore, we compared these results with healthy controls. METHODS: We performed a systematic review and meta-analysis on the literature by searching PubMed and EMBASE (January 2000-December 2015) on CP and vitamin D. Primary outcome was prevalence of vitamin D insufficiency (<75 nmoL/L) and deficiency (<50 nmoL/L) in CP patients. When available, data of CP patients were compared with healthy controls. RESULTS: Nine studies were included in our meta-analysis, reporting on the prevalence of vitamin D insufficiency/deficiency in 465 patients (mean age 41 years (range 18-60), 81% male) and in 378 controls (mean age 40 years (range 18-67), 76% male). Pooled prevalence of vitamin D insufficiency and deficiency in CP patients was 83% and 65%, respectively. Calculated odds ratio (OR) of vitamin D insufficiency and deficiency between CP patients and controls was 1.34 (0.54-3.29) and 1.14 (0.70-1.85), respectively (p > 0.05). CONCLUSION: There is a high prevalence of vitamin D insufficiency and deficiency in CP patients. Nevertheless, there is no significant difference in prevalence of vitamin D insufficiency and deficiency compared to healthy controls. Further research should indicate the clinical relevance and consequences of these findings for clinical practice. SN - 1424-3911 UR - https://www.unboundmedicine.com/medline/citation/27453461/Systematic_review_and_meta_analysis_on_the_prevalence_of_vitamin_D_deficiency_in_patients_with_chronic_pancreatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1424-3903(16)31163-2 DB - PRIME DP - Unbound Medicine ER -