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Relations between Recent Past Leisure Activities with Risks of Dementia and Cognitive Functions after Stroke.
PLoS One. 2016; 11(7):e0159952.Plos

Abstract

BACKGROUND

Leisure activity participation has been shown to lower risks of cognitive decline in non-stroke populations. However, effects of leisure activities participation upon cognitive functions and risk of dementia after stroke are unclear. The purpose of this study is to examine the effects of recent past leisure activities participation upon cognitive functions and risk of incident dementia after stroke.

METHODS

Hospital-based, retrospective cohort study. 88 of 1,013 patients with stroke or TIA having no prestroke dementia were diagnosed to have incident poststroke dementia (PSD) 3-6 months after stroke. Regular participation (≥3 times per week) in intellectual, recreational, social and physical activities over the year before the index stroke was retrospectively recorded at 3-6 months after stroke.

RESULTS

Logistic regression analyses showed that regular participation in intellectual (RR 0.36, 95%CI 0.20-0.63) and stretching & toning physical exercise (0.37, 0.21-0.64) was significantly associated with a reduced risk of PSD after controlling for age, education, prestroke cognitive decline, stroke subtype, prior strokes and chronic brain changes including white matter changes, old infarcts and global atrophy. Results were similar in patients with past strokes in unadjusted models. Participation in increased number of activities in general (r = 0.41, p<0.01) and in intellectual (r = 0.40, p<0.01), recreational (r = 0.24, p<0.01), strenuous aerobic (r = 0.23, p<0.01) and mind-body (r = 0.10, p<0.01) activities was associated with higher poststroke Mini-mental State Examination scores in models adjusted for prestroke cognitive decline.

CONCLUSIONS

Regular participation in intellectual activities and stretching & toning exercise was associated with a significantly reduced short-term risk of PSD in patients with and without recurrent strokes. Participation in greater number of recent past leisure activities was associated with better poststroke cognitive performance. Findings of this retrospective cohort study call for studies of activity intervention for prevention of cognitive decline in individuals at elevated risk of stroke.

Authors+Show Affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and Ministry of Education of China, Guangzhou, China.Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.Department of Psychiatry, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, China.Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27454124

Citation

Wong, Adrian, et al. "Relations Between Recent Past Leisure Activities With Risks of Dementia and Cognitive Functions After Stroke." PloS One, vol. 11, no. 7, 2016, pp. e0159952.
Wong A, Lau AY, Lo E, et al. Relations between Recent Past Leisure Activities with Risks of Dementia and Cognitive Functions after Stroke. PLoS One. 2016;11(7):e0159952.
Wong, A., Lau, A. Y., Lo, E., Tang, M., Wang, Z., Liu, W., Tanner, N., Chau, N., Law, L., Shi, L., Chu, W. C., Yang, J., Xiong, Y. Y., Lam, B. Y., Au, L., Chan, A. Y., Soo, Y., Leung, T. W., Wong, L. K., ... Mok, V. C. (2016). Relations between Recent Past Leisure Activities with Risks of Dementia and Cognitive Functions after Stroke. PloS One, 11(7), e0159952. https://doi.org/10.1371/journal.pone.0159952
Wong A, et al. Relations Between Recent Past Leisure Activities With Risks of Dementia and Cognitive Functions After Stroke. PLoS One. 2016;11(7):e0159952. PubMed PMID: 27454124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relations between Recent Past Leisure Activities with Risks of Dementia and Cognitive Functions after Stroke. AU - Wong,Adrian, AU - Lau,Alexander Y L, AU - Lo,Eugene, AU - Tang,Michael, AU - Wang,Zhaolu, AU - Liu,Wenyan, AU - Tanner,Nicole, AU - Chau,Natalie, AU - Law,Lorraine, AU - Shi,Lin, AU - Chu,Winnie C W, AU - Yang,Jie, AU - Xiong,Yun-Yun, AU - Lam,Bonnie Y K, AU - Au,Lisa, AU - Chan,Anne Y Y, AU - Soo,Yannie, AU - Leung,Thomas W H, AU - Wong,Lawrence K S, AU - Lam,Linda C W, AU - Mok,Vincent C T, Y1 - 2016/07/25/ PY - 2016/01/04/received PY - 2016/07/11/accepted PY - 2016/7/26/entrez PY - 2016/7/28/pubmed PY - 2017/7/25/medline SP - e0159952 EP - e0159952 JF - PloS one JO - PLoS One VL - 11 IS - 7 N2 - BACKGROUND: Leisure activity participation has been shown to lower risks of cognitive decline in non-stroke populations. However, effects of leisure activities participation upon cognitive functions and risk of dementia after stroke are unclear. The purpose of this study is to examine the effects of recent past leisure activities participation upon cognitive functions and risk of incident dementia after stroke. METHODS: Hospital-based, retrospective cohort study. 88 of 1,013 patients with stroke or TIA having no prestroke dementia were diagnosed to have incident poststroke dementia (PSD) 3-6 months after stroke. Regular participation (≥3 times per week) in intellectual, recreational, social and physical activities over the year before the index stroke was retrospectively recorded at 3-6 months after stroke. RESULTS: Logistic regression analyses showed that regular participation in intellectual (RR 0.36, 95%CI 0.20-0.63) and stretching & toning physical exercise (0.37, 0.21-0.64) was significantly associated with a reduced risk of PSD after controlling for age, education, prestroke cognitive decline, stroke subtype, prior strokes and chronic brain changes including white matter changes, old infarcts and global atrophy. Results were similar in patients with past strokes in unadjusted models. Participation in increased number of activities in general (r = 0.41, p<0.01) and in intellectual (r = 0.40, p<0.01), recreational (r = 0.24, p<0.01), strenuous aerobic (r = 0.23, p<0.01) and mind-body (r = 0.10, p<0.01) activities was associated with higher poststroke Mini-mental State Examination scores in models adjusted for prestroke cognitive decline. CONCLUSIONS: Regular participation in intellectual activities and stretching & toning exercise was associated with a significantly reduced short-term risk of PSD in patients with and without recurrent strokes. Participation in greater number of recent past leisure activities was associated with better poststroke cognitive performance. Findings of this retrospective cohort study call for studies of activity intervention for prevention of cognitive decline in individuals at elevated risk of stroke. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27454124/Relations_between_Recent_Past_Leisure_Activities_with_Risks_of_Dementia_and_Cognitive_Functions_after_Stroke_ L2 - https://dx.plos.org/10.1371/journal.pone.0159952 DB - PRIME DP - Unbound Medicine ER -