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Anti-N-methyl-d-aspartate receptor encephalitis in a patient with neuromyelitis optica spectrum disorders.
Mult Scler Relat Disord. 2016 Jul; 8:74-7.MS

Abstract

We described a female patient with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis occurring sequentially with neuromyelitis optica spectrum disorders (NMOSD). The 19-year-old patient initially presented a diencephalic syndrome with aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) and brain lesions which involving bilateral medial temporal lobes and periependymal surfaces of the third ventricle on magnetic resonance imaging (MRI). Ten months later, the patient developed cognitive impairment, psychiatric symptoms and dyskinesia with left basal ganglia lesions on brain MRI. Meanwhile, the anti-NMDAR antibodies were positive in the patient's serum and cerebrospinal fluid, while the screening tests for an ovarian teratoma and other tumors were all negative. Hence, the patient was diagnosed NMOSD and anti-NMDAR encephalitis followed by low-dose rituximab treatment with a good response. This case was another evidence for demyelinating syndromes overlapping anti-NMDAR encephalitis in Chinese patients.

Authors+Show Affiliations

Department of Neurology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. Electronic address: luojj1986@126.com.Department of Neurology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. Electronic address: cranehebmu@sina.com.Department of Neurology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. Electronic address: sunweibjmu@163.com.Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China. Electronic address: zhj7509@163.com.Department of Neurology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. Electronic address: haohj1963@126.com.Department of Neurology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. Electronic address: gaofh2011@126.com.Department of Neurology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. Electronic address: ynhuang@sina.com.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27456878

Citation

Luo, Jing-Jing, et al. "Anti-N-methyl-d-aspartate Receptor Encephalitis in a Patient With Neuromyelitis Optica Spectrum Disorders." Multiple Sclerosis and Related Disorders, vol. 8, 2016, pp. 74-7.
Luo JJ, Lv H, Sun W, et al. Anti-N-methyl-d-aspartate receptor encephalitis in a patient with neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 2016;8:74-7.
Luo, J. J., Lv, H., Sun, W., Zhao, J., Hao, H. J., Gao, F., & Huang, Y. N. (2016). Anti-N-methyl-d-aspartate receptor encephalitis in a patient with neuromyelitis optica spectrum disorders. Multiple Sclerosis and Related Disorders, 8, 74-7. https://doi.org/10.1016/j.msard.2016.05.002
Luo JJ, et al. Anti-N-methyl-d-aspartate Receptor Encephalitis in a Patient With Neuromyelitis Optica Spectrum Disorders. Mult Scler Relat Disord. 2016;8:74-7. PubMed PMID: 27456878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-N-methyl-d-aspartate receptor encephalitis in a patient with neuromyelitis optica spectrum disorders. AU - Luo,Jing-Jing, AU - Lv,He, AU - Sun,Wei, AU - Zhao,Juan, AU - Hao,Hong-Jun, AU - Gao,Feng, AU - Huang,Yi-Ning, Y1 - 2016/05/02/ PY - 2015/12/29/received PY - 2016/04/10/revised PY - 2016/05/01/accepted PY - 2016/7/27/entrez PY - 2016/7/28/pubmed PY - 2017/2/28/medline KW - Anti-N-methyl-d-aspartate receptor encephalitis KW - Aquaporin-4 KW - Demyelination KW - N-methyl-d-aspartate receptor KW - Neuromyelitis optica spectrum disorders SP - 74 EP - 7 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 8 N2 - We described a female patient with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis occurring sequentially with neuromyelitis optica spectrum disorders (NMOSD). The 19-year-old patient initially presented a diencephalic syndrome with aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) and brain lesions which involving bilateral medial temporal lobes and periependymal surfaces of the third ventricle on magnetic resonance imaging (MRI). Ten months later, the patient developed cognitive impairment, psychiatric symptoms and dyskinesia with left basal ganglia lesions on brain MRI. Meanwhile, the anti-NMDAR antibodies were positive in the patient's serum and cerebrospinal fluid, while the screening tests for an ovarian teratoma and other tumors were all negative. Hence, the patient was diagnosed NMOSD and anti-NMDAR encephalitis followed by low-dose rituximab treatment with a good response. This case was another evidence for demyelinating syndromes overlapping anti-NMDAR encephalitis in Chinese patients. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/27456878/Anti_N_methyl_d_aspartate_receptor_encephalitis_in_a_patient_with_neuromyelitis_optica_spectrum_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(16)30053-0 DB - PRIME DP - Unbound Medicine ER -