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Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia.
BMC Gastroenterol. 2016 Jul 25; 16(1):75.BG

Abstract

BACKGROUND

The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms.

METHODS

The study was a retrospective review of 100 consecutive pediatric patients, age 8-17 years, diagnosed with FD. All had completed a standardized medical history including gastrointestinal and systemic symptoms as well as specific symptoms related to GERD and OBS. The frequency of overlap with IBS, GERD, and OBS were determined for the whole group and for those fulfilling adult FD subtype criteria. Individual symptoms were also compared by FD subtype.

RESULTS

Overlap IBS was present in 33 % of the FD patients. At least one GERD symptom was present in 74 % of patients with 41 % reporting heartburn. At least one OBS symptom was present in 44 % of patients with 29 % reporting urinary urgency. Other than pain, the most common reported gastrointestinal symptom was nausea (86 %). Systemic symptoms were common. Overlap syndromes/symptoms did not vary by FD subtype. Postprandial distress syndrome was associated with pain with eating, weight loss, and waking at night to have a stool.

CONCLUSIONS

FD is a heterogeneous condition in children and adolescents with significant variability in the presence of gastrointestinal and non-gastrointestinal symptoms and overlap syndromes. Varying symptom profiles need to be accounted for and analyzed in studies involving subjects with FD.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA. cfriesen@cmh.edu.Division of Gastroenterology, Hepatology, and Nutrition, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.Division of Developmental and Behavioral Sciences, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27457769

Citation

Friesen, Craig A., et al. "Prevalence of Overlap Syndromes and Symptoms in Pediatric Functional Dyspepsia." BMC Gastroenterology, vol. 16, no. 1, 2016, p. 75.
Friesen CA, Rosen JM, Schurman JV. Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia. BMC Gastroenterol. 2016;16(1):75.
Friesen, C. A., Rosen, J. M., & Schurman, J. V. (2016). Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia. BMC Gastroenterology, 16(1), 75. https://doi.org/10.1186/s12876-016-0495-3
Friesen CA, Rosen JM, Schurman JV. Prevalence of Overlap Syndromes and Symptoms in Pediatric Functional Dyspepsia. BMC Gastroenterol. 2016 Jul 25;16(1):75. PubMed PMID: 27457769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia. AU - Friesen,Craig A, AU - Rosen,John M, AU - Schurman,Jennifer V, Y1 - 2016/07/25/ PY - 2016/04/16/received PY - 2016/07/21/accepted PY - 2016/7/27/entrez PY - 2016/7/28/pubmed PY - 2017/2/1/medline KW - Functional dyspepsia KW - Gastroesophageal reflux KW - Irritable bowel syndrome KW - Overactive bladder syndrome SP - 75 EP - 75 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 16 IS - 1 N2 - BACKGROUND: The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms. METHODS: The study was a retrospective review of 100 consecutive pediatric patients, age 8-17 years, diagnosed with FD. All had completed a standardized medical history including gastrointestinal and systemic symptoms as well as specific symptoms related to GERD and OBS. The frequency of overlap with IBS, GERD, and OBS were determined for the whole group and for those fulfilling adult FD subtype criteria. Individual symptoms were also compared by FD subtype. RESULTS: Overlap IBS was present in 33 % of the FD patients. At least one GERD symptom was present in 74 % of patients with 41 % reporting heartburn. At least one OBS symptom was present in 44 % of patients with 29 % reporting urinary urgency. Other than pain, the most common reported gastrointestinal symptom was nausea (86 %). Systemic symptoms were common. Overlap syndromes/symptoms did not vary by FD subtype. Postprandial distress syndrome was associated with pain with eating, weight loss, and waking at night to have a stool. CONCLUSIONS: FD is a heterogeneous condition in children and adolescents with significant variability in the presence of gastrointestinal and non-gastrointestinal symptoms and overlap syndromes. Varying symptom profiles need to be accounted for and analyzed in studies involving subjects with FD. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/27457769/Prevalence_of_overlap_syndromes_and_symptoms_in_pediatric_functional_dyspepsia_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-016-0495-3 DB - PRIME DP - Unbound Medicine ER -