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One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects.
J Clin Endocrinol Metab. 2016 Nov; 101(11):4030-4038.JC

Abstract

CONTEXT

Individuals with glycated hemoglobin (HbA1c)-defined prediabetes (HbA1c value of 5.7-6.4%) and 1-hour plasma glucose ≥155 mg/dL during an oral glucose tolerance test have an increased risk of developing type 2 diabetes.

OBJECTIVE

To evaluate the degree to which HbA1c-defined prediabetes and 1-hour postload glucose ≥155 mg/dL individually and jointly associate with hepatic steatosis and related biomarkers.

DESIGN AND PATIENTS

A cross-sectional analysis was performed on 1108 White individuals.

SETTING

Ambulatory care.

MAIN OUTCOME MEASURES

Anthropometric and metabolic characteristics including hepatic steatosis assessed by ultrasonography.

RESULTS

Compared with the normal group (HbA1c <5.7%), HbA1c-defined prediabetic and diabetic individuals exhibit higher values of fasting, 1-hour, and 2-hour postload glucose; fasting and 2-hour postload insulin; triglycerides; uric acid; homeostasis model of assessment for insulin resistance; liver insulin resistance index; liver enzymes; and inflammatory biomarkers; and lower levels of high-density lipoprotein cholesterol and IGF-1. Prediabetic and diabetic subjects have increased risk of hepatic steatosis (1.5- and 2.46-fold, respectively). Stratifying participants according to HbA1c and 1-hour postload glucose, we found that individuals with HbA1c-defined prediabetes and 1-hour postload glucose ≥155 mg/dL have significantly higher risk of hepatic steatosis as compared with individuals with HbA1c-defined prediabetes but 1-hour postload glucose <155 mg/dL. Individuals with HbA1c-defined prediabetes and 1-hour postload glucose ≥155 mg/dL exhibit higher values of liver enzymes; fasting, 1-hour, and 2-hour postload glucose; insulin; triglycerides; uric acid; and inflammatory biomarkers; and lower levels of high-density lipoprotein and IGF-1.

CONCLUSIONS

These data suggest that a value of 1-hour postload glucose ≥155 mg/dL may be helpful to identify a subset of individuals within HbA1c-defined glycemic categories at higher risk of hepatic steatosis.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27459528

Citation

Fiorentino, Teresa Vanessa, et al. "One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects." The Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 11, 2016, pp. 4030-4038.
Fiorentino TV, Andreozzi F, Mannino GC, et al. One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects. J Clin Endocrinol Metab. 2016;101(11):4030-4038.
Fiorentino, T. V., Andreozzi, F., Mannino, G. C., Pedace, E., Perticone, M., Sciacqua, A., Perticone, F., & Sesti, G. (2016). One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects. The Journal of Clinical Endocrinology and Metabolism, 101(11), 4030-4038.
Fiorentino TV, et al. One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects. J Clin Endocrinol Metab. 2016;101(11):4030-4038. PubMed PMID: 27459528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects. AU - Fiorentino,Teresa Vanessa, AU - Andreozzi,Francesco, AU - Mannino,Gaia Chiara, AU - Pedace,Elisabetta, AU - Perticone,Maria, AU - Sciacqua,Angela, AU - Perticone,Francesco, AU - Sesti,Giorgio, Y1 - 2016/07/26/ PY - 2016/11/5/pubmed PY - 2017/6/3/medline PY - 2016/7/27/entrez SP - 4030 EP - 4038 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 101 IS - 11 N2 - CONTEXT: Individuals with glycated hemoglobin (HbA1c)-defined prediabetes (HbA1c value of 5.7-6.4%) and 1-hour plasma glucose ≥155 mg/dL during an oral glucose tolerance test have an increased risk of developing type 2 diabetes. OBJECTIVE: To evaluate the degree to which HbA1c-defined prediabetes and 1-hour postload glucose ≥155 mg/dL individually and jointly associate with hepatic steatosis and related biomarkers. DESIGN AND PATIENTS: A cross-sectional analysis was performed on 1108 White individuals. SETTING: Ambulatory care. MAIN OUTCOME MEASURES: Anthropometric and metabolic characteristics including hepatic steatosis assessed by ultrasonography. RESULTS: Compared with the normal group (HbA1c <5.7%), HbA1c-defined prediabetic and diabetic individuals exhibit higher values of fasting, 1-hour, and 2-hour postload glucose; fasting and 2-hour postload insulin; triglycerides; uric acid; homeostasis model of assessment for insulin resistance; liver insulin resistance index; liver enzymes; and inflammatory biomarkers; and lower levels of high-density lipoprotein cholesterol and IGF-1. Prediabetic and diabetic subjects have increased risk of hepatic steatosis (1.5- and 2.46-fold, respectively). Stratifying participants according to HbA1c and 1-hour postload glucose, we found that individuals with HbA1c-defined prediabetes and 1-hour postload glucose ≥155 mg/dL have significantly higher risk of hepatic steatosis as compared with individuals with HbA1c-defined prediabetes but 1-hour postload glucose <155 mg/dL. Individuals with HbA1c-defined prediabetes and 1-hour postload glucose ≥155 mg/dL exhibit higher values of liver enzymes; fasting, 1-hour, and 2-hour postload glucose; insulin; triglycerides; uric acid; and inflammatory biomarkers; and lower levels of high-density lipoprotein and IGF-1. CONCLUSIONS: These data suggest that a value of 1-hour postload glucose ≥155 mg/dL may be helpful to identify a subset of individuals within HbA1c-defined glycemic categories at higher risk of hepatic steatosis. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/27459528/One_Hour_Postload_Hyperglycemia_Confers_Higher_Risk_of_Hepatic_Steatosis_to_HbA1c_Defined_Prediabetic_Subjects_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-1856 DB - PRIME DP - Unbound Medicine ER -