Tags

Type your tag names separated by a space and hit enter

Heterogeneity of incidence and outcome of acute exacerbation in idiopathic interstitial pneumonia.
Respirology. 2016 11; 21(8):1431-1437.R

Abstract

BACKGROUND AND OBJECTIVE

Acute exacerbations (AEs) of idiopathic pulmonary fibrosis (IPF) and other idiopathic interstitial pneumonia (IIP) have a poor prognosis. This study aims to clarify the incidence and prognosis of AE in IPF and the other IIP.

METHODS

A total of 229 patients were enrolled, of whom 92 had IPF and 137 had 'IIP other than IPF' based on the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association (ATS/ERS/JRS/ALAT) 2011 IPF Guidelines. IIP other than IPF included 11 patients with a surgical lung biopsy (SLB) and the remainder without such a biopsy. IIP other than IPF was further classified into IIP with a 'possible usual interstitial pneumonia (UIP)' pattern on HRCT (n = 75) and IIP with 'inconsistent with UIP' pattern (n = 62) based on published guidelines. Predictors of AE and the prognosis after AE were examined in these groups.

RESULTS

The 1-year incidence of AE in IPF, IIP with possible UIP HRCT patterns and IIP with inconsistent with UIP HRCT patterns was 16.5%, 8.9% and 4.0%, respectively. AE occurred significantly more frequently in IPF than in IIP with possible UIP and inconsistent with UIP HRCT patterns after adjustment for BMI, modified Medical Research Council score and %forced vital capacity. Prognosis of AE-IIP with possible UIP HRCT pattern was significantly worse than that of AE-IPF.

CONCLUSION

Although AE occurred significantly less frequently in IIP with possible UIP and inconsistent with UIP HRCT patterns than in IPF, the prognosis of AE-IIP with possible UIP HRCT patterns might be worse than that of AE-IPF.

Authors+Show Affiliations

Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan. Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan. Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Division of Clinical Trial, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan. Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Department of Pathology, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan. Department of Pathology, National Hospital Organization Minami Wakayama Medical Center, Tanabe, Japan.Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan. Department of Radiology, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan.Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan. giichi@kch.hosp.go.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27460223

Citation

Arai, Toru, et al. "Heterogeneity of Incidence and Outcome of Acute Exacerbation in Idiopathic Interstitial Pneumonia." Respirology (Carlton, Vic.), vol. 21, no. 8, 2016, pp. 1431-1437.
Arai T, Kagawa T, Sasaki Y, et al. Heterogeneity of incidence and outcome of acute exacerbation in idiopathic interstitial pneumonia. Respirology. 2016;21(8):1431-1437.
Arai, T., Kagawa, T., Sasaki, Y., Sugawara, R., Sugimoto, C., Tachibana, K., Kitaichi, M., Akira, M., Hayashi, S., & Inoue, Y. (2016). Heterogeneity of incidence and outcome of acute exacerbation in idiopathic interstitial pneumonia. Respirology (Carlton, Vic.), 21(8), 1431-1437. https://doi.org/10.1111/resp.12862
Arai T, et al. Heterogeneity of Incidence and Outcome of Acute Exacerbation in Idiopathic Interstitial Pneumonia. Respirology. 2016;21(8):1431-1437. PubMed PMID: 27460223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterogeneity of incidence and outcome of acute exacerbation in idiopathic interstitial pneumonia. AU - Arai,Toru, AU - Kagawa,Tomoko, AU - Sasaki,Yumiko, AU - Sugawara,Reiko, AU - Sugimoto,Chikatoshi, AU - Tachibana,Kazunobu, AU - Kitaichi,Masanori, AU - Akira,Masanori, AU - Hayashi,Seiji, AU - Inoue,Yoshikazu, Y1 - 2016/07/26/ PY - 2015/08/11/received PY - 2016/04/22/revised PY - 2016/05/17/accepted PY - 2016/7/28/pubmed PY - 2017/12/12/medline PY - 2016/7/28/entrez KW - acute exacerbation KW - high-resolution computed tomography KW - idiopathic interstitial pneumonia KW - idiopathic pulmonary fibrosis KW - usual interstitial pneumonia SP - 1431 EP - 1437 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 21 IS - 8 N2 - BACKGROUND AND OBJECTIVE: Acute exacerbations (AEs) of idiopathic pulmonary fibrosis (IPF) and other idiopathic interstitial pneumonia (IIP) have a poor prognosis. This study aims to clarify the incidence and prognosis of AE in IPF and the other IIP. METHODS: A total of 229 patients were enrolled, of whom 92 had IPF and 137 had 'IIP other than IPF' based on the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association (ATS/ERS/JRS/ALAT) 2011 IPF Guidelines. IIP other than IPF included 11 patients with a surgical lung biopsy (SLB) and the remainder without such a biopsy. IIP other than IPF was further classified into IIP with a 'possible usual interstitial pneumonia (UIP)' pattern on HRCT (n = 75) and IIP with 'inconsistent with UIP' pattern (n = 62) based on published guidelines. Predictors of AE and the prognosis after AE were examined in these groups. RESULTS: The 1-year incidence of AE in IPF, IIP with possible UIP HRCT patterns and IIP with inconsistent with UIP HRCT patterns was 16.5%, 8.9% and 4.0%, respectively. AE occurred significantly more frequently in IPF than in IIP with possible UIP and inconsistent with UIP HRCT patterns after adjustment for BMI, modified Medical Research Council score and %forced vital capacity. Prognosis of AE-IIP with possible UIP HRCT pattern was significantly worse than that of AE-IPF. CONCLUSION: Although AE occurred significantly less frequently in IIP with possible UIP and inconsistent with UIP HRCT patterns than in IPF, the prognosis of AE-IIP with possible UIP HRCT patterns might be worse than that of AE-IPF. SN - 1440-1843 UR - https://www.unboundmedicine.com/medline/citation/27460223/Heterogeneity_of_incidence_and_outcome_of_acute_exacerbation_in_idiopathic_interstitial_pneumonia_ L2 - https://doi.org/10.1111/resp.12862 DB - PRIME DP - Unbound Medicine ER -