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No association between vitamin D levels around time of birth and later risk of developing oligo- and polyarticular juvenile idiopathic arthritis: a Danish case-cohort study.
Scand J Rheumatol. 2017 Mar; 46(2):104-111.SJ

Abstract

OBJECTIVES

Basic and epidemiological studies on rheumatic autoimmune diseases have suggested an association between vitamin D levels around time of birth and disease risk. The literature on vitamin D and juvenile idiopathic arthritis (JIA) is scarce. We hypothesized that low levels of 25-hydroxyvitamin D [25(OH)D] around time of birth would be associated with increased risk of oligo- or polyarticular JIA.

METHOD

We conducted a case-cohort study of validated cases diagnosed with oligo- and polyarticular JIA (1993-2012) and controls matched on date of birth. Cases and controls were born in the period 1983-2010. Cases were diagnosed using international criteria. The concentration of 25(OH)D was assessed from neonatal dried blood spot (DBS) samples using high-sensitivity liquid chromatography tandem mass spectrometry (LC-MS/MS). Odds ratios (ORs) were calculated using conditional logistic regression and a two-way analysis of variance (ANOVA) was used to test for season and birth year 25(OH)D variations. A total of 300 matched pairs were included in the statistical analyses.

RESULTS

No significant association was found between levels of 25(OH)D and JIA risk in the adjusted model [OR (per 25 nmol/L increase) 1.2, 95% confidence interval (CI) 0.9-1.6, p = 0.2]. 25(OH)D levels were found to fluctuate significantly with season (p < 0.0001) and year (p < 0.0001). The median level of 25(OH)D was 34.4 nmol/L in cases and 31.5 nmol/L in controls.

CONCLUSIONS

Our study does not support the hypothesis that a window of vulnerability exists around time of birth with regard to 25(OH)D levels and later JIA risk. Further studies should explore whether 25(OH)D levels during early pregnancy or infancy may influence JIA risk.

Authors+Show Affiliations

a Copenhagen Diabetes Research Centre (CPH-DIRECT), Department of Paediatrics , Herlev University Hospital , Herlev , Denmark. b Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.c Department of Public Health, Section of Biostatistics , University of Copenhagen , Copenhagen , Denmark.d Paediatric Rheumatology Clinic , Rigshospitalet , Copenhagen , Denmark. e Department of Paediatrics , Næstved Hospital , Næstved , Denmark.d Paediatric Rheumatology Clinic , Rigshospitalet , Copenhagen , Denmark.f Department of Congenital Disorders , Statens Serum Institute , Copenhagen , Denmark.f Department of Congenital Disorders , Statens Serum Institute , Copenhagen , Denmark.g National Institute of Public Health , University of Southern Denmark , Copenhagen , Denmark.h Department of Nutrition , Harvard TH Chan School of Public Health , Boston , MA , USA.a Copenhagen Diabetes Research Centre (CPH-DIRECT), Department of Paediatrics , Herlev University Hospital , Herlev , Denmark.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27460412

Citation

Thorsen, S U., et al. "No Association Between Vitamin D Levels Around Time of Birth and Later Risk of Developing Oligo- and Polyarticular Juvenile Idiopathic Arthritis: a Danish Case-cohort Study." Scandinavian Journal of Rheumatology, vol. 46, no. 2, 2017, pp. 104-111.
Thorsen SU, Pipper CB, Alberdi-Saugstrup M, et al. No association between vitamin D levels around time of birth and later risk of developing oligo- and polyarticular juvenile idiopathic arthritis: a Danish case-cohort study. Scand J Rheumatol. 2017;46(2):104-111.
Thorsen, S. U., Pipper, C. B., Alberdi-Saugstrup, M., Nielsen, S., Cohen, A., Lundqvist, M., Thygesen, L. C., Ascherio, A., & Svensson, J. (2017). No association between vitamin D levels around time of birth and later risk of developing oligo- and polyarticular juvenile idiopathic arthritis: a Danish case-cohort study. Scandinavian Journal of Rheumatology, 46(2), 104-111. https://doi.org/10.1080/03009742.2016.1178325
Thorsen SU, et al. No Association Between Vitamin D Levels Around Time of Birth and Later Risk of Developing Oligo- and Polyarticular Juvenile Idiopathic Arthritis: a Danish Case-cohort Study. Scand J Rheumatol. 2017;46(2):104-111. PubMed PMID: 27460412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No association between vitamin D levels around time of birth and later risk of developing oligo- and polyarticular juvenile idiopathic arthritis: a Danish case-cohort study. AU - Thorsen,S U, AU - Pipper,C B, AU - Alberdi-Saugstrup,M, AU - Nielsen,S, AU - Cohen,A, AU - Lundqvist,M, AU - Thygesen,L C, AU - Ascherio,A, AU - Svensson,J, Y1 - 2016/07/27/ PY - 2016/7/28/pubmed PY - 2017/3/31/medline PY - 2016/7/28/entrez SP - 104 EP - 111 JF - Scandinavian journal of rheumatology JO - Scand. J. Rheumatol. VL - 46 IS - 2 N2 - OBJECTIVES: Basic and epidemiological studies on rheumatic autoimmune diseases have suggested an association between vitamin D levels around time of birth and disease risk. The literature on vitamin D and juvenile idiopathic arthritis (JIA) is scarce. We hypothesized that low levels of 25-hydroxyvitamin D [25(OH)D] around time of birth would be associated with increased risk of oligo- or polyarticular JIA. METHOD: We conducted a case-cohort study of validated cases diagnosed with oligo- and polyarticular JIA (1993-2012) and controls matched on date of birth. Cases and controls were born in the period 1983-2010. Cases were diagnosed using international criteria. The concentration of 25(OH)D was assessed from neonatal dried blood spot (DBS) samples using high-sensitivity liquid chromatography tandem mass spectrometry (LC-MS/MS). Odds ratios (ORs) were calculated using conditional logistic regression and a two-way analysis of variance (ANOVA) was used to test for season and birth year 25(OH)D variations. A total of 300 matched pairs were included in the statistical analyses. RESULTS: No significant association was found between levels of 25(OH)D and JIA risk in the adjusted model [OR (per 25 nmol/L increase) 1.2, 95% confidence interval (CI) 0.9-1.6, p = 0.2]. 25(OH)D levels were found to fluctuate significantly with season (p < 0.0001) and year (p < 0.0001). The median level of 25(OH)D was 34.4 nmol/L in cases and 31.5 nmol/L in controls. CONCLUSIONS: Our study does not support the hypothesis that a window of vulnerability exists around time of birth with regard to 25(OH)D levels and later JIA risk. Further studies should explore whether 25(OH)D levels during early pregnancy or infancy may influence JIA risk. SN - 1502-7732 UR - https://www.unboundmedicine.com/medline/citation/27460412/No_association_between_vitamin_D_levels_around_time_of_birth_and_later_risk_of_developing_oligo__and_polyarticular_juvenile_idiopathic_arthritis:_a_Danish_case_cohort_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/03009742.2016.1178325 DB - PRIME DP - Unbound Medicine ER -