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Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis.
Eur J Orthod. 2017 Aug 01; 39(4):345-351.EJ

Abstract

Aim

To evaluate the shape of the craniofacial complex in patients with tooth agenesis and compare it to matched controls.

Subjects and methods

The sample comprised 456 patients that were allocated to three groups: the agenesis group of 100 patients with at least one missing tooth, excluding third molars, the third molar agenesis group (3dMAG; one to four missing third molars) of 52 patients and the control group (CG) of 304 patients with no missing teeth. The main craniofacial structures depicted on lateral cephalograms were digitized and traced with 15 curves and 127 landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the whole craniofacial complex. For statistical analysis, permutation tests were used (10 000 permutations without replacement).

Results

Approximately half of the sample's variability was described by the first three principal components. Comparisons within the whole sample revealed sexual dimorphism of the craniofacial complex and its structures (P < 0.01). Differences between the agenesis group and matched controls were found in the shape of all craniofacial structures except for the cranial base (P < 0.05). Specifically, patients with agenesis presented with Class III tendency and hypodivergent skeletal pattern. However, the comparison between the 3dMAG and matched CG revealed no differences.

Conclusion

The shape of the craniofacial complex differs in patients with tooth agenesis suggesting that common factors are implicated in tooth development and craniofacial morphology.

Authors+Show Affiliations

Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, Greece.Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27464525

Citation

Cocos, Alina, and Demetrios J. Halazonetis. "Craniofacial Shape Differs in Patients With Tooth Agenesis: Geometric Morphometric Analysis." European Journal of Orthodontics, vol. 39, no. 4, 2017, pp. 345-351.
Cocos A, Halazonetis DJ. Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis. Eur J Orthod. 2017;39(4):345-351.
Cocos, A., & Halazonetis, D. J. (2017). Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis. European Journal of Orthodontics, 39(4), 345-351. https://doi.org/10.1093/ejo/cjw049
Cocos A, Halazonetis DJ. Craniofacial Shape Differs in Patients With Tooth Agenesis: Geometric Morphometric Analysis. Eur J Orthod. 2017 Aug 1;39(4):345-351. PubMed PMID: 27464525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis. AU - Cocos,Alina, AU - Halazonetis,Demetrios J, PY - 2016/7/29/pubmed PY - 2018/11/27/medline PY - 2016/7/29/entrez SP - 345 EP - 351 JF - European journal of orthodontics JO - Eur J Orthod VL - 39 IS - 4 N2 - Aim : To evaluate the shape of the craniofacial complex in patients with tooth agenesis and compare it to matched controls. Subjects and methods : The sample comprised 456 patients that were allocated to three groups: the agenesis group of 100 patients with at least one missing tooth, excluding third molars, the third molar agenesis group (3dMAG; one to four missing third molars) of 52 patients and the control group (CG) of 304 patients with no missing teeth. The main craniofacial structures depicted on lateral cephalograms were digitized and traced with 15 curves and 127 landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the whole craniofacial complex. For statistical analysis, permutation tests were used (10 000 permutations without replacement). Results : Approximately half of the sample's variability was described by the first three principal components. Comparisons within the whole sample revealed sexual dimorphism of the craniofacial complex and its structures (P < 0.01). Differences between the agenesis group and matched controls were found in the shape of all craniofacial structures except for the cranial base (P < 0.05). Specifically, patients with agenesis presented with Class III tendency and hypodivergent skeletal pattern. However, the comparison between the 3dMAG and matched CG revealed no differences. Conclusion : The shape of the craniofacial complex differs in patients with tooth agenesis suggesting that common factors are implicated in tooth development and craniofacial morphology. SN - 1460-2210 UR - https://www.unboundmedicine.com/medline/citation/27464525/Craniofacial_shape_differs_in_patients_with_tooth_agenesis:_geometric_morphometric_analysis_ L2 - https://academic.oup.com/ejo/article-lookup/doi/10.1093/ejo/cjw049 DB - PRIME DP - Unbound Medicine ER -