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Iron Status at Age 6 Months in Colombian Infants Exclusively Breast-fed for 4 to 5 Versus 6 Months.
J Pediatr Gastroenterol Nutr. 2017 03; 64(3):465-471.JP

Abstract

OBJECTIVES

The optimal age for introducing complementary feeding to breast-fed infants may differ depending on the setting. Prolonged exclusive breast-feeding (EBF) protects against infection but may increase the risk of iron deficiency (ID)/anaemia (IDA) in vulnerable infants. The aim of the present study was to compare haemoglobin (Hb), serum ferritin (SF), anaemia (Hb < 11 g/L), ID (SF < 12 μg/L) and IDA (Hb < 10.5 g/dL + Hct < 33% + ID) using observational analyses in 6-month old infants from Bogota, Colombia who were EBF for 4 to 5 versus 6 months or older, and examine predictors.

METHODS

Infant feeding was recorded, anthropometry performed, and blood obtained for Hb and SF at 6 months in healthy term infants (birth weight > 2500 g), all EBF for ≥4 months.

RESULTS

One hundred eight infants (54% boys) were recruited; 46% EBF for 4 to 5 months, 54% EBF at 6 months. Prevalence of anaemia, ID, and IDA was 20%, 10%, and 5%, with no significant difference between EBF4-5 and EBF6 groups. In multivariate models, anaemia/ID were predicted by greater weight gain from 0 to 6 months, and anaemia also by caesarean delivery; Hb was lower in infants with higher intake of cows' milk; SF was lower in boys and those with greater weight gain. EBF4-5 versus EBF6 was not a significant predictor of any outcome.

CONCLUSIONS

Anaemia and ID were common at 6 months but were not affected by EBF for 4 to 5 versus 6 months, suggesting 6 months EBF is safe in this population. Further research is, however, required to examine effects on later iron status. The findings highlight the need to emphasise avoidance of cow's milk before 12 months.

Authors+Show Affiliations

*Nutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javariana, Bogota, Colombia †Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27467112

Citation

Olaya, Gilma A., et al. "Iron Status at Age 6 Months in Colombian Infants Exclusively Breast-fed for 4 to 5 Versus 6 Months." Journal of Pediatric Gastroenterology and Nutrition, vol. 64, no. 3, 2017, pp. 465-471.
Olaya GA, Lawson M, Fewtrell M. Iron Status at Age 6 Months in Colombian Infants Exclusively Breast-fed for 4 to 5 Versus 6 Months. J Pediatr Gastroenterol Nutr. 2017;64(3):465-471.
Olaya, G. A., Lawson, M., & Fewtrell, M. (2017). Iron Status at Age 6 Months in Colombian Infants Exclusively Breast-fed for 4 to 5 Versus 6 Months. Journal of Pediatric Gastroenterology and Nutrition, 64(3), 465-471. https://doi.org/10.1097/MPG.0000000000001301
Olaya GA, Lawson M, Fewtrell M. Iron Status at Age 6 Months in Colombian Infants Exclusively Breast-fed for 4 to 5 Versus 6 Months. J Pediatr Gastroenterol Nutr. 2017;64(3):465-471. PubMed PMID: 27467112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron Status at Age 6 Months in Colombian Infants Exclusively Breast-fed for 4 to 5 Versus 6 Months. AU - Olaya,Gilma A, AU - Lawson,Margaret, AU - Fewtrell,Mary, PY - 2016/7/29/pubmed PY - 2018/1/5/medline PY - 2016/7/29/entrez SP - 465 EP - 471 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 64 IS - 3 N2 - OBJECTIVES: The optimal age for introducing complementary feeding to breast-fed infants may differ depending on the setting. Prolonged exclusive breast-feeding (EBF) protects against infection but may increase the risk of iron deficiency (ID)/anaemia (IDA) in vulnerable infants. The aim of the present study was to compare haemoglobin (Hb), serum ferritin (SF), anaemia (Hb < 11 g/L), ID (SF < 12 μg/L) and IDA (Hb < 10.5 g/dL + Hct < 33% + ID) using observational analyses in 6-month old infants from Bogota, Colombia who were EBF for 4 to 5 versus 6 months or older, and examine predictors. METHODS: Infant feeding was recorded, anthropometry performed, and blood obtained for Hb and SF at 6 months in healthy term infants (birth weight > 2500 g), all EBF for ≥4 months. RESULTS: One hundred eight infants (54% boys) were recruited; 46% EBF for 4 to 5 months, 54% EBF at 6 months. Prevalence of anaemia, ID, and IDA was 20%, 10%, and 5%, with no significant difference between EBF4-5 and EBF6 groups. In multivariate models, anaemia/ID were predicted by greater weight gain from 0 to 6 months, and anaemia also by caesarean delivery; Hb was lower in infants with higher intake of cows' milk; SF was lower in boys and those with greater weight gain. EBF4-5 versus EBF6 was not a significant predictor of any outcome. CONCLUSIONS: Anaemia and ID were common at 6 months but were not affected by EBF for 4 to 5 versus 6 months, suggesting 6 months EBF is safe in this population. Further research is, however, required to examine effects on later iron status. The findings highlight the need to emphasise avoidance of cow's milk before 12 months. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/27467112/Iron_Status_at_Age_6_Months_in_Colombian_Infants_Exclusively_Breast_fed_for_4_to_5_Versus_6_Months_ L2 - https://doi.org/10.1097/MPG.0000000000001301 DB - PRIME DP - Unbound Medicine ER -