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Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study.
Biomed Pharmacother. 2016 Aug; 82:345-54.BP

Abstract

Chrysin (5,7-dihydroxyflavone) is a major component of some traditional medicinal herbs present in honey, propolis and many plant extracts. The study was aimed to illuminate the effect of chrysin in the pathogenesis of ammonium chloride (NH4Cl) induced hyperammonemic rat model in a dose dependent manner. Rats were injected with NH4Cl (100mg/kg b.w.) by intraperitonially (i.p) thrice a week for 8 consecutive weeks for the induction of experimental hyperammonemia. Hyperammonemic rats were treated with chrysin by orally at a dose of 25, 50 & 100mg/kg b.w. respectively. Protective effect of chrysin against hyperammonemia was evaluated by performing biochemical estimations and morphopathological investigations of hematoxylin and eosin stained sections of liver, brain and kidney tissues. Supplementation of chrysin reinstated the levels of blood ammonia, plasma urea, uric acid, total bilirubin, creatinine, brain glutamate, glutamine, nitric oxide (NO) and the activities of Na(+)/K(+)-ATPase, and liver marker enzymes. On the other hand increased level of plasma urea was observed in chrysin treated rats as compared with hyperammonemic rats. Chrysin administration caused distortion of hepatic, brain and kidney architecture as shown by histological examination. Chrysin at a dose (100mg/kg b.w.) showed an utmost decline in the level of all biochemical estimations. Both biochemical and morphological studies clearly revealed that chrysin protects against cell injury induced by ammonia intoxication in a dose-response manner with respect to endogenous antioxidants and hypoammonemic effects.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608002, India.Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608002, India. Electronic address: nvkbiochem@yahoo.co.in.Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608002, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27470372

Citation

Renuka, Mani, et al. "Chrysin, a Flavonoid Attenuates Histological Changes of Hyperammonemic Rats: a Dose Dependent Study." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 82, 2016, pp. 345-54.
Renuka M, Vijayakumar N, Ramakrishnan A. Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study. Biomed Pharmacother. 2016;82:345-54.
Renuka, M., Vijayakumar, N., & Ramakrishnan, A. (2016). Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 82, 345-54. https://doi.org/10.1016/j.biopha.2016.05.013
Renuka M, Vijayakumar N, Ramakrishnan A. Chrysin, a Flavonoid Attenuates Histological Changes of Hyperammonemic Rats: a Dose Dependent Study. Biomed Pharmacother. 2016;82:345-54. PubMed PMID: 27470372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study. AU - Renuka,Mani, AU - Vijayakumar,Natesan, AU - Ramakrishnan,Arumugam, Y1 - 2016/05/24/ PY - 2016/04/07/received PY - 2016/05/10/revised PY - 2016/05/10/accepted PY - 2016/7/30/entrez PY - 2016/7/30/pubmed PY - 2017/2/1/medline KW - Chrysin KW - Histological changes KW - Hyperammonemia KW - Liver marker enzymes KW - NO KW - Na(+)/K(+)-ATPase SP - 345 EP - 54 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 82 N2 - Chrysin (5,7-dihydroxyflavone) is a major component of some traditional medicinal herbs present in honey, propolis and many plant extracts. The study was aimed to illuminate the effect of chrysin in the pathogenesis of ammonium chloride (NH4Cl) induced hyperammonemic rat model in a dose dependent manner. Rats were injected with NH4Cl (100mg/kg b.w.) by intraperitonially (i.p) thrice a week for 8 consecutive weeks for the induction of experimental hyperammonemia. Hyperammonemic rats were treated with chrysin by orally at a dose of 25, 50 & 100mg/kg b.w. respectively. Protective effect of chrysin against hyperammonemia was evaluated by performing biochemical estimations and morphopathological investigations of hematoxylin and eosin stained sections of liver, brain and kidney tissues. Supplementation of chrysin reinstated the levels of blood ammonia, plasma urea, uric acid, total bilirubin, creatinine, brain glutamate, glutamine, nitric oxide (NO) and the activities of Na(+)/K(+)-ATPase, and liver marker enzymes. On the other hand increased level of plasma urea was observed in chrysin treated rats as compared with hyperammonemic rats. Chrysin administration caused distortion of hepatic, brain and kidney architecture as shown by histological examination. Chrysin at a dose (100mg/kg b.w.) showed an utmost decline in the level of all biochemical estimations. Both biochemical and morphological studies clearly revealed that chrysin protects against cell injury induced by ammonia intoxication in a dose-response manner with respect to endogenous antioxidants and hypoammonemic effects. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/27470372/Chrysin_a_flavonoid_attenuates_histological_changes_of_hyperammonemic_rats:_A_dose_dependent_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(16)30437-1 DB - PRIME DP - Unbound Medicine ER -