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Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica.
Biosens Bioelectron. 2017 Feb 15; 88:63-70.BB

Abstract

We demonstrate a photonic crystal biosilica surface-enhanced Raman scattering (SERS) substrate based on a diatom frustule with in-situ synthesized silver nanoparticles (Ag NPs) to detect explosive molecules from nanoliter (nL) solution. By integrating high density Ag NPs inside the nanopores of diatom biosilica, which is not achievable by traditional self-assembly techniques, we obtained ultra-high SERS sensitivity due to dual enhancement mechanisms. First, the hybrid plasmonic-photonic crystal biosilica with three dimensional morphologies was obtained by electroless-deposited Ag seeds at nanometer sized diatom frustule surface, which provides high density hot spots as well as strongly coupled optical resonances with the photonic crystal structure of diatom frustules. Second, we discovered that the evaporation-driven microscopic flow combined with the strong hydrophilic surface of diatom frustules is capable of concentrating the analyte molecules, which offers a simple yet effective mechanism to accelerate the mass transport into the SERS substrate. Using the inkjet printing technology, we are able to deliver multiple 100pico-liter (pL) volume droplets with pinpoint accuracy into a single diatom frustule with dimension around 30µm×7µm×5µm, which allows for label-free detection of explosive molecules such as trinitrotoluene (TNT) down to 10-10M in concentration and 2.7×10-15g in mass from 120nL solution. Our research illustrates a new paradigm of SERS sensing to detect trace level of chemical compounds from minimum volume of analyte using nature created photonic crystal biosilica materials.

Authors+Show Affiliations

School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331 USA.School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331 USA.School of Chemical, Biological & Environmental Engineering, Oregon State University, Corvallis, OR, 97331 USA.School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331 USA.School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331 USA.School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331 USA.School of Chemical, Biological & Environmental Engineering, Oregon State University, Corvallis, OR, 97331 USA.School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331 USA. Electronic address: wang@eecs.oregonstate.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27471144

Citation

Kong, Xianming, et al. "Detecting Explosive Molecules From Nanoliter Solution: a New Paradigm of SERS Sensing On Hydrophilic Photonic Crystal Biosilica." Biosensors & Bioelectronics, vol. 88, 2017, pp. 63-70.
Kong X, Xi Y, Le Duff P, et al. Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica. Biosens Bioelectron. 2017;88:63-70.
Kong, X., Xi, Y., Le Duff, P., Chong, X., Li, E., Ren, F., Rorrer, G. L., & Wang, A. X. (2017). Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica. Biosensors & Bioelectronics, 88, 63-70. https://doi.org/10.1016/j.bios.2016.07.062
Kong X, et al. Detecting Explosive Molecules From Nanoliter Solution: a New Paradigm of SERS Sensing On Hydrophilic Photonic Crystal Biosilica. Biosens Bioelectron. 2017 Feb 15;88:63-70. PubMed PMID: 27471144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica. AU - Kong,Xianming, AU - Xi,Yuting, AU - Le Duff,Paul, AU - Chong,Xinyuan, AU - Li,Erwen, AU - Ren,Fanghui, AU - Rorrer,Gregory L, AU - Wang,Alan X, Y1 - 2016/07/19/ PY - 2016/05/20/received PY - 2016/07/05/revised PY - 2016/07/19/accepted PY - 2016/7/30/pubmed PY - 2017/2/23/medline PY - 2016/7/30/entrez KW - Diatom biosilica KW - Hydrophilic surface KW - Inkjet printing KW - Photonic crystal KW - Surface-enhanced Raman scattering SP - 63 EP - 70 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 88 N2 - We demonstrate a photonic crystal biosilica surface-enhanced Raman scattering (SERS) substrate based on a diatom frustule with in-situ synthesized silver nanoparticles (Ag NPs) to detect explosive molecules from nanoliter (nL) solution. By integrating high density Ag NPs inside the nanopores of diatom biosilica, which is not achievable by traditional self-assembly techniques, we obtained ultra-high SERS sensitivity due to dual enhancement mechanisms. First, the hybrid plasmonic-photonic crystal biosilica with three dimensional morphologies was obtained by electroless-deposited Ag seeds at nanometer sized diatom frustule surface, which provides high density hot spots as well as strongly coupled optical resonances with the photonic crystal structure of diatom frustules. Second, we discovered that the evaporation-driven microscopic flow combined with the strong hydrophilic surface of diatom frustules is capable of concentrating the analyte molecules, which offers a simple yet effective mechanism to accelerate the mass transport into the SERS substrate. Using the inkjet printing technology, we are able to deliver multiple 100pico-liter (pL) volume droplets with pinpoint accuracy into a single diatom frustule with dimension around 30µm×7µm×5µm, which allows for label-free detection of explosive molecules such as trinitrotoluene (TNT) down to 10-10M in concentration and 2.7×10-15g in mass from 120nL solution. Our research illustrates a new paradigm of SERS sensing to detect trace level of chemical compounds from minimum volume of analyte using nature created photonic crystal biosilica materials. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/27471144/Detecting_explosive_molecules_from_nanoliter_solution:_A_new_paradigm_of_SERS_sensing_on_hydrophilic_photonic_crystal_biosilica_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(16)30691-1 DB - PRIME DP - Unbound Medicine ER -