Tags

Type your tag names separated by a space and hit enter

Ocfentanil overdose fatality in the recreational drug scene.
Forensic Sci Int. 2016 Sep; 266:469-473.FS

Abstract

This paper describes the first reported death involving ocfentanil, a potent synthetic opioid and structure analogue of fentanyl abused as a new psychoactive substance in the recreational drug scene. A 17-year-old man with a history of illegal substance abuse was found dead in his home after snorting a brown powder purchased over the internet with bitcoins. Acetaminophen, caffeine and ocfentanil were identified in the powder by gas chromatography mass spectrometry and reversed-phase liquid chromatography with diode array detector. Quantitation of ocfentanil in biological samples was performed using a target analysis based on liquid-liquid extraction and ultra performance liquid chromatography tandem mass spectrometry. In the femoral blood taken at the external body examination, the following concentrations were measured: ocfentanil 15.3μg/L, acetaminophen 45mg/L and caffeine 0.23mg/L. Tissues sampled at autopsy were analyzed to study the distribution of ocfentanil. The comprehensive systematic toxicological analysis on the post-mortem blood and tissue samples was negative for other compounds. Based on circumstantial evidence, autopsy findings and the results of the toxicological analysis, the medical examiner concluded that the cause of death was an acute intoxication with ocfentanil. The manner of death was assumed to be accidental after snorting the powder.

Authors+Show Affiliations

Eurofins Forensics Belgium, Lieven Bauwensstraat 6, 8200 Brugge, Belgium.Eurofins Forensics Belgium, Lieven Bauwensstraat 6, 8200 Brugge, Belgium. Electronic address: jancordonnier@eurofins.be.Emergency Department, Algemeen Stedelijk Ziekenhuis, Merestraat 80, 9300 Aalst, Belgium; Department of Forensic Medicine, Ghent University, Campus UZ , De Pintelaan 185, 9000 Gent, Belgium.ChemTox, Rue Grüninger 3, 67405 Illkirch, France.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27471990

Citation

Coopman, Vera, et al. "Ocfentanil Overdose Fatality in the Recreational Drug Scene." Forensic Science International, vol. 266, 2016, pp. 469-473.
Coopman V, Cordonnier J, De Leeuw M, et al. Ocfentanil overdose fatality in the recreational drug scene. Forensic Sci Int. 2016;266:469-473.
Coopman, V., Cordonnier, J., De Leeuw, M., & Cirimele, V. (2016). Ocfentanil overdose fatality in the recreational drug scene. Forensic Science International, 266, 469-473. https://doi.org/10.1016/j.forsciint.2016.07.005
Coopman V, et al. Ocfentanil Overdose Fatality in the Recreational Drug Scene. Forensic Sci Int. 2016;266:469-473. PubMed PMID: 27471990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocfentanil overdose fatality in the recreational drug scene. AU - Coopman,Vera, AU - Cordonnier,Jan, AU - De Leeuw,Marc, AU - Cirimele,Vincent, Y1 - 2016/07/17/ PY - 2016/05/17/received PY - 2016/07/04/revised PY - 2016/07/05/accepted PY - 2016/7/30/entrez PY - 2016/7/30/pubmed PY - 2018/2/21/medline KW - Fentanyl analogue KW - New psychoactive substances (NPS) KW - Ocfentanil KW - Tissue distribution KW - Ultra performance liquid chromatography mass spectrometry (UPLC-MS) SP - 469 EP - 473 JF - Forensic science international JO - Forensic Sci Int VL - 266 N2 - This paper describes the first reported death involving ocfentanil, a potent synthetic opioid and structure analogue of fentanyl abused as a new psychoactive substance in the recreational drug scene. A 17-year-old man with a history of illegal substance abuse was found dead in his home after snorting a brown powder purchased over the internet with bitcoins. Acetaminophen, caffeine and ocfentanil were identified in the powder by gas chromatography mass spectrometry and reversed-phase liquid chromatography with diode array detector. Quantitation of ocfentanil in biological samples was performed using a target analysis based on liquid-liquid extraction and ultra performance liquid chromatography tandem mass spectrometry. In the femoral blood taken at the external body examination, the following concentrations were measured: ocfentanil 15.3μg/L, acetaminophen 45mg/L and caffeine 0.23mg/L. Tissues sampled at autopsy were analyzed to study the distribution of ocfentanil. The comprehensive systematic toxicological analysis on the post-mortem blood and tissue samples was negative for other compounds. Based on circumstantial evidence, autopsy findings and the results of the toxicological analysis, the medical examiner concluded that the cause of death was an acute intoxication with ocfentanil. The manner of death was assumed to be accidental after snorting the powder. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/27471990/Ocfentanil_overdose_fatality_in_the_recreational_drug_scene_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(16)30309-7 DB - PRIME DP - Unbound Medicine ER -