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Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography.
Invest Ophthalmol Vis Sci. 2016 07 01; 57(9):OCT526-32.IO

Abstract

PURPOSE

We observed and analyzed the morphologic characteristics of polypoidal lesions and abnormal branching vascular network (BVN) in patients with polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA).

METHODS

A retrospective observational case series was done of patients with PCV. All patients were scanned with a 70-kHz spectral-domain OCT system using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images of these patients were compared to those from indocyanine green angiography (ICGA). Semiautomated segmentation was used to further analyze the polypoidal lesion and the BVN.

RESULTS

We studied 13 eyes of 13 patients 51 to 69 years old. A total of 11 patients were treatment-naive. Two patients had multiple anti-VEGF injections and one underwent photodynamic therapy (PDT). Optical coherence tomography angiography was able to detect the BVN in all cases. Using cross-sectional OCTA, BVN locations were shown to be in the space between the RPE and Bruch's membrane. Using en face OCTA, the BVN vascular pattern could be shown more clearly than by ICGA. Polypoidal lesions showed high flow signals in different patterns in 12 cases in the outer retina slab. Using cross-sectional OCTA, the polyps were shown to be just below the top of the pigment epithelial detachment (PED). In one case, the polypoidal lesion was not detectable at the outer retina slab.

CONCLUSIONS

Optical coherence tomography angiography is a noninvasive imaging tool for detecting vascular changes in PCV. Branching vascular networks showed more clearly on OCTA than on ICGA. Polypoidal lesions had variable patterns on OCTA and were not always detected. The OCTA patterns of the polypoidal lesions and the BVN are helpful in understanding the pathology of PCV.

Authors+Show Affiliations

Department of Ophthalmology and Vision Science Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.Department of Ophthalmology and Vision Science Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China.Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.Department of Ophthalmology and Vision Science Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.Department of Ophthalmology and Vision Science Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China.Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.

Pub Type(s)

Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27472276

Citation

Wang, Min, et al. "Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography." Investigative Ophthalmology & Visual Science, vol. 57, no. 9, 2016, pp. OCT526-32.
Wang M, Zhou Y, Gao SS, et al. Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016;57(9):OCT526-32.
Wang, M., Zhou, Y., Gao, S. S., Liu, W., Huang, Y., Huang, D., & Jia, Y. (2016). Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography. Investigative Ophthalmology & Visual Science, 57(9), OCT526-32. https://doi.org/10.1167/iovs.15-18955
Wang M, et al. Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 07 1;57(9):OCT526-32. PubMed PMID: 27472276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography. AU - Wang,Min, AU - Zhou,Yao, AU - Gao,Simon S, AU - Liu,Wei, AU - Huang,Yongheng, AU - Huang,David, AU - Jia,Yali, PY - 2016/7/30/entrez PY - 2016/7/30/pubmed PY - 2017/6/24/medline SP - OCT526 EP - 32 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 57 IS - 9 N2 - PURPOSE: We observed and analyzed the morphologic characteristics of polypoidal lesions and abnormal branching vascular network (BVN) in patients with polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA). METHODS: A retrospective observational case series was done of patients with PCV. All patients were scanned with a 70-kHz spectral-domain OCT system using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images of these patients were compared to those from indocyanine green angiography (ICGA). Semiautomated segmentation was used to further analyze the polypoidal lesion and the BVN. RESULTS: We studied 13 eyes of 13 patients 51 to 69 years old. A total of 11 patients were treatment-naive. Two patients had multiple anti-VEGF injections and one underwent photodynamic therapy (PDT). Optical coherence tomography angiography was able to detect the BVN in all cases. Using cross-sectional OCTA, BVN locations were shown to be in the space between the RPE and Bruch's membrane. Using en face OCTA, the BVN vascular pattern could be shown more clearly than by ICGA. Polypoidal lesions showed high flow signals in different patterns in 12 cases in the outer retina slab. Using cross-sectional OCTA, the polyps were shown to be just below the top of the pigment epithelial detachment (PED). In one case, the polypoidal lesion was not detectable at the outer retina slab. CONCLUSIONS: Optical coherence tomography angiography is a noninvasive imaging tool for detecting vascular changes in PCV. Branching vascular networks showed more clearly on OCTA than on ICGA. Polypoidal lesions had variable patterns on OCTA and were not always detected. The OCTA patterns of the polypoidal lesions and the BVN are helpful in understanding the pathology of PCV. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/27472276/Evaluating_Polypoidal_Choroidal_Vasculopathy_With_Optical_Coherence_Tomography_Angiography_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.15-18955 DB - PRIME DP - Unbound Medicine ER -