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Comparison of a Powdered, Acidified Liquid, and Non-Acidified Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants.
Nutrients. 2016 Jul 26; 8(8)N

Abstract

We previously compared infant outcomes between a powdered human milk fortifier (P-HMF) vs. acidified liquid HMF (AL-HMF). A non-acidified liquid HMF (NAL-HMF) is now commercially available. The purpose of this study is to compare growth and outcomes of premature infants receiving P-HMF, AL-HMF or NAL-HMF. An Institutional Review Board (IRB) approved retrospective chart review compared infant outcomes (born < 2000 g) who received one of three HMF. Growth, enteral nutrition, laboratory and demographic data were compared. 120 infants were included (P-HMF = 46, AL-HMF = 23, NAL-HMF = 51). AL-HMF infants grew slower in g/day (median 23.66 vs. P-HMF 31.27, NAL-HMF 31.74 (p < 0.05)) and in g/kg/day, median 10.59 vs. 15.37, 14.03 (p < 0.0001). AL-HMF vs. NAL-HMF infants were smaller at 36 weeks gestational age (median 2046 vs. 2404 g, p < 0.05). However AL-HMF infants received more daily calories (p = 0.21) and protein (p < 0.0001), mean 129 cal/kg, 4.2 g protein/kg vs. P-HMF 117 cal/kg, 3.7 g protein/kg , NAL-HMF 120 cal/kg, 4.0 g protein/kg. AL-HMF infants exhibited lower carbon dioxide levels after day of life 14 and 30 (p < 0.0001, p = 0.0038). Three AL-HMF infants (13%) developed necrotizing enterocolitis (NEC) vs. no infants in the remaining groups (p = 0.0056). A NAL-HMF is the most optimal choice for premature human milk-fed infants in a high acuity neonatal intensive care unit (NICU).

Authors+Show Affiliations

Newborn Intensive Care Unit, Nebraska Medicine, 981200 Nebraska Medical Center, Omaha, NE 68198, USA. mthoene@nebraskamed.com.College of Public Health, University of Nebraska Medical Center, 984375 Nebraska Medical Center, Omaha, NE 68198-4375, USA. elyden@unmc.edu.Department of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. kara.weishaar@unmc.edu.Department of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. elizabeth.elliott@unmc.edu.Department of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. Ruomei.Wu@Creighton.edu.Department of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. katelyn.white@huskers.unl.edu.Department of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. hayley.timm@grmep.com.Department of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. alanders@unmc.edu.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27472359

Citation

Thoene, Melissa, et al. "Comparison of a Powdered, Acidified Liquid, and Non-Acidified Liquid Human Milk Fortifier On Clinical Outcomes in Premature Infants." Nutrients, vol. 8, no. 8, 2016.
Thoene M, Lyden E, Weishaar K, et al. Comparison of a Powdered, Acidified Liquid, and Non-Acidified Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants. Nutrients. 2016;8(8).
Thoene, M., Lyden, E., Weishaar, K., Elliott, E., Wu, R., White, K., Timm, H., & Anderson-Berry, A. (2016). Comparison of a Powdered, Acidified Liquid, and Non-Acidified Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants. Nutrients, 8(8). https://doi.org/10.3390/nu8080451
Thoene M, et al. Comparison of a Powdered, Acidified Liquid, and Non-Acidified Liquid Human Milk Fortifier On Clinical Outcomes in Premature Infants. Nutrients. 2016 Jul 26;8(8) PubMed PMID: 27472359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of a Powdered, Acidified Liquid, and Non-Acidified Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants. AU - Thoene,Melissa, AU - Lyden,Elizabeth, AU - Weishaar,Kara, AU - Elliott,Elizabeth, AU - Wu,Ruomei, AU - White,Katelyn, AU - Timm,Hayley, AU - Anderson-Berry,Ann, Y1 - 2016/07/26/ PY - 2016/05/20/received PY - 2016/07/14/revised PY - 2016/07/18/accepted PY - 2016/7/30/entrez PY - 2016/7/30/pubmed PY - 2017/3/18/medline KW - acidosis KW - enteral nutrition KW - fortifier KW - growth KW - human milk KW - necrotizing enterocolitis KW - premature infant JF - Nutrients JO - Nutrients VL - 8 IS - 8 N2 - We previously compared infant outcomes between a powdered human milk fortifier (P-HMF) vs. acidified liquid HMF (AL-HMF). A non-acidified liquid HMF (NAL-HMF) is now commercially available. The purpose of this study is to compare growth and outcomes of premature infants receiving P-HMF, AL-HMF or NAL-HMF. An Institutional Review Board (IRB) approved retrospective chart review compared infant outcomes (born < 2000 g) who received one of three HMF. Growth, enteral nutrition, laboratory and demographic data were compared. 120 infants were included (P-HMF = 46, AL-HMF = 23, NAL-HMF = 51). AL-HMF infants grew slower in g/day (median 23.66 vs. P-HMF 31.27, NAL-HMF 31.74 (p < 0.05)) and in g/kg/day, median 10.59 vs. 15.37, 14.03 (p < 0.0001). AL-HMF vs. NAL-HMF infants were smaller at 36 weeks gestational age (median 2046 vs. 2404 g, p < 0.05). However AL-HMF infants received more daily calories (p = 0.21) and protein (p < 0.0001), mean 129 cal/kg, 4.2 g protein/kg vs. P-HMF 117 cal/kg, 3.7 g protein/kg , NAL-HMF 120 cal/kg, 4.0 g protein/kg. AL-HMF infants exhibited lower carbon dioxide levels after day of life 14 and 30 (p < 0.0001, p = 0.0038). Three AL-HMF infants (13%) developed necrotizing enterocolitis (NEC) vs. no infants in the remaining groups (p = 0.0056). A NAL-HMF is the most optimal choice for premature human milk-fed infants in a high acuity neonatal intensive care unit (NICU). SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/27472359/Comparison_of_a_Powdered_Acidified_Liquid_and_Non_Acidified_Liquid_Human_Milk_Fortifier_on_Clinical_Outcomes_in_Premature_Infants_ L2 - http://www.mdpi.com/resolver?pii=nu8080451 DB - PRIME DP - Unbound Medicine ER -