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Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease.
Oncotarget. 2016 Aug 23; 7(34):54183-54193.O

Abstract

Numerous studies have demonstrated that dietary intervention may promote health and help prevent Alzheimer's disease (AD). We recently reported that bee products of royal jelly (RJ) and enzyme-treated royal jelly (eRJ) were potent to promote healthy aging in C. elegans. Here, we examined whether RJ/eRJ consumption may benefit to mitigate the AD symptom in the disease model of C. elegans. Our results showed that RJ/eRJ supplementation significantly delayed the body paralysis in AD worms, suggesting the β-amyloid (Aβ) toxicity attenuation effects of RJ/eRJ. Genetic analyses suggested that RJ/eRJ-mediated alleviation of Aβ toxicity in AD worms required DAF-16, rather than HSF-1 and SKN-1, in an insulin/IGF signaling dependent manner. Moreover, RJ/eRJ modulated the transactivity of DAF-16 and dramatically improved the protein solubility in aged worms. Given protein solubility is a hallmark of healthy proteostasis, our findings demonstrated that RJ/eRJ supplementation improved proteostasis, and this promotion depended on the transactivity of DAF-16. Collectively, the present study not only elucidated the possible anti-AD mechanism of RJ/eRJ, but also provided evidence from a practical point of view to shed light on the extensive correlation of proteostasis and the prevention of neurodegenerative disorders.

Authors+Show Affiliations

Department of Biological Sciences, Clemson University, Clemson, SC, USA.Department of Biological Sciences, Clemson University, Clemson, SC, USA. Institute for Engaged Aging, Clemson University, Clemson, SC, USA.Department of Biological Sciences, Clemson University, Clemson, SC, USA. Institute for Engaged Aging, Clemson University, Clemson, SC, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27472466

Citation

Wang, Xiaoxia, et al. "Royal Jelly Promotes DAF-16-mediated Proteostasis to Tolerate Β-amyloid Toxicity in C. Elegans Model of Alzheimer's Disease." Oncotarget, vol. 7, no. 34, 2016, pp. 54183-54193.
Wang X, Cao M, Dong Y. Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease. Oncotarget. 2016;7(34):54183-54193.
Wang, X., Cao, M., & Dong, Y. (2016). Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease. Oncotarget, 7(34), 54183-54193. https://doi.org/10.18632/oncotarget.10857
Wang X, Cao M, Dong Y. Royal Jelly Promotes DAF-16-mediated Proteostasis to Tolerate Β-amyloid Toxicity in C. Elegans Model of Alzheimer's Disease. Oncotarget. 2016 Aug 23;7(34):54183-54193. PubMed PMID: 27472466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease. AU - Wang,Xiaoxia, AU - Cao,Min, AU - Dong,Yuqing, PY - 2016/04/21/received PY - 2016/07/07/accepted PY - 2016/7/30/pubmed PY - 2018/2/6/medline PY - 2016/7/30/entrez KW - Alzheimer’s disease KW - DAF-16 KW - Gerotarget KW - proteostasis KW - royal jelly KW - β-amyloid SP - 54183 EP - 54193 JF - Oncotarget JO - Oncotarget VL - 7 IS - 34 N2 - Numerous studies have demonstrated that dietary intervention may promote health and help prevent Alzheimer's disease (AD). We recently reported that bee products of royal jelly (RJ) and enzyme-treated royal jelly (eRJ) were potent to promote healthy aging in C. elegans. Here, we examined whether RJ/eRJ consumption may benefit to mitigate the AD symptom in the disease model of C. elegans. Our results showed that RJ/eRJ supplementation significantly delayed the body paralysis in AD worms, suggesting the β-amyloid (Aβ) toxicity attenuation effects of RJ/eRJ. Genetic analyses suggested that RJ/eRJ-mediated alleviation of Aβ toxicity in AD worms required DAF-16, rather than HSF-1 and SKN-1, in an insulin/IGF signaling dependent manner. Moreover, RJ/eRJ modulated the transactivity of DAF-16 and dramatically improved the protein solubility in aged worms. Given protein solubility is a hallmark of healthy proteostasis, our findings demonstrated that RJ/eRJ supplementation improved proteostasis, and this promotion depended on the transactivity of DAF-16. Collectively, the present study not only elucidated the possible anti-AD mechanism of RJ/eRJ, but also provided evidence from a practical point of view to shed light on the extensive correlation of proteostasis and the prevention of neurodegenerative disorders. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/27472466/Royal_jelly_promotes_DAF_16_mediated_proteostasis_to_tolerate_β_amyloid_toxicity_in_C__elegans_model_of_Alzheimer's_disease_ L2 - https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.10857 DB - PRIME DP - Unbound Medicine ER -