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Association between Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease.
J Alzheimers Dis 2016; 54(1):157-68JA

Abstract

In the course of Alzheimer's disease (AD), early pathological changes in the brain start decades before any clinical manifestation. The concentration levels of AD cerebrospinal fluid (CSF) biomarkers, such as amyloid-β1-42 (Aβ1-42), total tau (T-tau), and phosphorylated tau (P-tau), may reflect a cerebral pathology facilitating an early diagnosis of the disease and predicting a cognitive deterioration. The aim of this study was to estimate the prevalence of AD CSF biomarkers in those individuals with a subjective cognitive decline (SCD), a mild cognitive impairment (MCI), and Alzheimer's dementia (AD-D), together with the relationships between the biomarkers, an APOE ɛ4 presence, and a verbal episodic memory performance. We included 252 patients from the memory clinic with a diagnosis of SCD (n = 85), MCI (n = 87), and AD-D (n = 80). A verbal episodic memory performance level was assessed and was based on a delayed recall trial from the 10-word list of an auditory verbal learning task (AVLT). We found that the patients with more severe cognitive impairments had significantly lower levels of Aβ1-42 and higher levels of T-tau and P-tau. This pattern was also typical for the APOE ɛ4 carriers, who had lower levels of Aβ1-42 than the noncarriers in the AD-D and MCI groups. The levels of T-tau and P-tau were significantly higher in the APOE ɛ4 carriers than in the noncarriers, but only in the MCI patients. The AVLT performance in the whole study samples was predicted by age, Aβ1-42, and the T-tau CSF biomarkers, but not by the APOE genotyping.

Authors+Show Affiliations

Department of Neurodegenerative Disorders, Mossakowski Medical Research Center, Polish Academy of Science, Warsaw, Poland.Faculty of Psychology, University of Warsaw, Warsaw, Poland.Department of Neurodegenerative Disorders, Mossakowski Medical Research Center, Polish Academy of Science, Warsaw, Poland.Department of Neurodegenerative Disorders, Mossakowski Medical Research Center, Polish Academy of Science, Warsaw, Poland.Neurology Clinic MSW Hospital, Warsaw, Poland.Neurology Clinic MSW Hospital, Warsaw, Poland.Neurology Clinic MSW Hospital, Warsaw, Poland.Department of Neurodegenerative Disorders, Mossakowski Medical Research Center, Polish Academy of Science, Warsaw, Poland.Department of Neurodegenerative Disorders, Mossakowski Medical Research Center, Polish Academy of Science, Warsaw, Poland.Department of Neurodegenerative Disorders, Mossakowski Medical Research Center, Polish Academy of Science, Warsaw, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27472875

Citation

Mandecka, Monika, et al. "Association Between Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 54, no. 1, 2016, pp. 157-68.
Mandecka M, Budziszewska M, Barczak A, et al. Association between Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease. J Alzheimers Dis. 2016;54(1):157-68.
Mandecka, M., Budziszewska, M., Barczak, A., Pepłońska, B., Chodakowska-Żebrowska, M., Filipek-Gliszczyńska, A., ... Gabryelewicz, T. (2016). Association between Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease. Journal of Alzheimer's Disease : JAD, 54(1), pp. 157-68. doi:10.3233/JAD-160176.
Mandecka M, et al. Association Between Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease. J Alzheimers Dis. 2016 07 29;54(1):157-68. PubMed PMID: 27472875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease. AU - Mandecka,Monika, AU - Budziszewska,Magdalena, AU - Barczak,Anna, AU - Pepłońska,Beata, AU - Chodakowska-Żebrowska,Małgorzata, AU - Filipek-Gliszczyńska,Anna, AU - Nesteruk,Marta, AU - Styczyńska,Maria, AU - Barcikowska,Maria, AU - Gabryelewicz,Tomasz, PY - 2016/7/30/entrez PY - 2016/7/30/pubmed PY - 2018/1/30/medline KW - APOE genotype KW - Alzheimer’s disease KW - auditory verbal learning task KW - cerebrospinal fluid biomarkers KW - diagnosis KW - mild cognitive impairment KW - subjective cognitive decline SP - 157 EP - 68 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 54 IS - 1 N2 - In the course of Alzheimer's disease (AD), early pathological changes in the brain start decades before any clinical manifestation. The concentration levels of AD cerebrospinal fluid (CSF) biomarkers, such as amyloid-β1-42 (Aβ1-42), total tau (T-tau), and phosphorylated tau (P-tau), may reflect a cerebral pathology facilitating an early diagnosis of the disease and predicting a cognitive deterioration. The aim of this study was to estimate the prevalence of AD CSF biomarkers in those individuals with a subjective cognitive decline (SCD), a mild cognitive impairment (MCI), and Alzheimer's dementia (AD-D), together with the relationships between the biomarkers, an APOE ɛ4 presence, and a verbal episodic memory performance. We included 252 patients from the memory clinic with a diagnosis of SCD (n = 85), MCI (n = 87), and AD-D (n = 80). A verbal episodic memory performance level was assessed and was based on a delayed recall trial from the 10-word list of an auditory verbal learning task (AVLT). We found that the patients with more severe cognitive impairments had significantly lower levels of Aβ1-42 and higher levels of T-tau and P-tau. This pattern was also typical for the APOE ɛ4 carriers, who had lower levels of Aβ1-42 than the noncarriers in the AD-D and MCI groups. The levels of T-tau and P-tau were significantly higher in the APOE ɛ4 carriers than in the noncarriers, but only in the MCI patients. The AVLT performance in the whole study samples was predicted by age, Aβ1-42, and the T-tau CSF biomarkers, but not by the APOE genotyping. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/27472875/Association_between_Cerebrospinal_Fluid_Biomarkers_for_Alzheimer's_Disease_APOE_Genotypes_and_Auditory_Verbal_Learning_Task_in_Subjective_Cognitive_Decline_Mild_Cognitive_Impairment_and_Alzheimer's_Disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-160176 DB - PRIME DP - Unbound Medicine ER -