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Resistance exercise improves physical fatigue in women with fibromyalgia: a randomized controlled trial.

Abstract

BACKGROUND

Fibromyalgia (FM) affects approximately 1-3 % of the general population. Fatigue limits the work ability and social life of patients with FM. A few studies of physical exercise have included measures of fatigue in FM, indicating that exercise can decrease fatigue levels. There is limited knowledge about the effects of resistance exercise on multiple dimensions of fatigue in FM. The present study is a sub-study of a multicenter randomized controlled trial in women with FM. The purpose of the present sub-study was to examine the effects of a person-centered progressive resistance exercise program on multiple dimensions of fatigue in women with FM, and to investigate predictors of the potential change in fatigue.

METHODS

A total of 130 women with FM (age 22-64 years) were included in this assessor-blinded randomized controlled multicenter trial examining the effects of person-centered progressive resistance exercise compared with an active control group. The intervention was performed twice a week for 15 weeks. Outcomes were five dimensions of fatigue measured with the Multidimensional Fatigue Inventory (MFI-20). Information about background was collected and the women also completed several health-related questionnaires. Multiple linear stepwise regression was used to analyze predictors of change in fatigue in the total population.

RESULTS

A higher improvement was found at the post-treatment examination for change in the resistance exercise group, as compared to change in the active control group in the MFI-20 subscale of physical fatigue (resistance group Δ -1.7, SD 4.3, controls Δ 0.0, SD 2.7, p = 0.013), with an effect size of 0.33. Sleep efficiency was the strongest predictor of change in the MFI-20 subscale general fatigue (beta = -0.54, p = 0.031, R (2) = 0.05). Participating in resistance exercise (beta = 1.90, p = 0.010) and working fewer hours per week (beta = 0.84, p = 0.005) were independent significant predictors of change in physical fatigue (R (2) = 0.14).

CONCLUSIONS

Person-centered progressive resistance exercise improved physical fatigue in women with FM when compared to an active control group.

TRIAL REGISTRATION

ClinicalTrials.gov NCT01226784 . Registered 21 October 2010.

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  • Authors+Show Affiliations

    ,

    Institute of Neuroscience and Physiology/Physiotherapy, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. anna.ericsson@vgregion.se. University of Gothenburg Centre for Person Centered Care (GPCC), Göteborg, Sweden. anna.ericsson@vgregion.se.

    ,

    Institute of Neuroscience and Physiology/Physiotherapy, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

    ,

    Institute of Neuroscience and Physiology/Physiotherapy, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. University of Gothenburg Centre for Person Centered Care (GPCC), Göteborg, Sweden.

    ,

    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital Stockholm, Stockholm, Sweden.

    ,

    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital Stockholm, Stockholm, Sweden.

    ,

    Institute of Medicine, Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

    ,

    Department of Medical and Health Sciences, Division of Community Medicine, Faculty of Medicine and Health Sciences, Linköping University, Pain and Rehabilitation Center, Anesthetics, Operations and Specialty Surgery Center, Region Östergötland, Linköping, Sweden.

    ,

    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

    Institute of Neuroscience and Physiology/Physiotherapy, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. University of Gothenburg Centre for Person Centered Care (GPCC), Göteborg, Sweden.

    Source

    Arthritis research & therapy 18: 2016 07 30 pg 176

    MeSH

    Adult
    Fatigue
    Female
    Fibromyalgia
    Humans
    Middle Aged
    Resistance Training
    Surveys and Questionnaires
    Sweden
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    27473164

    Citation

    Ericsson, Anna, et al. "Resistance Exercise Improves Physical Fatigue in Women With Fibromyalgia: a Randomized Controlled Trial." Arthritis Research & Therapy, vol. 18, 2016, p. 176.
    Ericsson A, Palstam A, Larsson A, et al. Resistance exercise improves physical fatigue in women with fibromyalgia: a randomized controlled trial. Arthritis Res Ther. 2016;18:176.
    Ericsson, A., Palstam, A., Larsson, A., Löfgren, M., Bileviciute-Ljungar, I., Bjersing, J., ... Mannerkorpi, K. (2016). Resistance exercise improves physical fatigue in women with fibromyalgia: a randomized controlled trial. Arthritis Research & Therapy, 18, p. 176. doi:10.1186/s13075-016-1073-3.
    Ericsson A, et al. Resistance Exercise Improves Physical Fatigue in Women With Fibromyalgia: a Randomized Controlled Trial. Arthritis Res Ther. 2016 07 30;18:176. PubMed PMID: 27473164.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Resistance exercise improves physical fatigue in women with fibromyalgia: a randomized controlled trial. AU - Ericsson,Anna, AU - Palstam,Annie, AU - Larsson,Anette, AU - Löfgren,Monika, AU - Bileviciute-Ljungar,Indre, AU - Bjersing,Jan, AU - Gerdle,Björn, AU - Kosek,Eva, AU - Mannerkorpi,Kaisa, Y1 - 2016/07/30/ PY - 2016/03/15/received PY - 2016/07/06/accepted PY - 2016/7/31/entrez PY - 2016/7/31/pubmed PY - 2017/11/9/medline KW - Exercise KW - Fatigue KW - Fibromyalgia KW - Randomized controlled trial KW - Resistance exercise SP - 176 EP - 176 JF - Arthritis research & therapy JO - Arthritis Res. Ther. VL - 18 N2 - BACKGROUND: Fibromyalgia (FM) affects approximately 1-3 % of the general population. Fatigue limits the work ability and social life of patients with FM. A few studies of physical exercise have included measures of fatigue in FM, indicating that exercise can decrease fatigue levels. There is limited knowledge about the effects of resistance exercise on multiple dimensions of fatigue in FM. The present study is a sub-study of a multicenter randomized controlled trial in women with FM. The purpose of the present sub-study was to examine the effects of a person-centered progressive resistance exercise program on multiple dimensions of fatigue in women with FM, and to investigate predictors of the potential change in fatigue. METHODS: A total of 130 women with FM (age 22-64 years) were included in this assessor-blinded randomized controlled multicenter trial examining the effects of person-centered progressive resistance exercise compared with an active control group. The intervention was performed twice a week for 15 weeks. Outcomes were five dimensions of fatigue measured with the Multidimensional Fatigue Inventory (MFI-20). Information about background was collected and the women also completed several health-related questionnaires. Multiple linear stepwise regression was used to analyze predictors of change in fatigue in the total population. RESULTS: A higher improvement was found at the post-treatment examination for change in the resistance exercise group, as compared to change in the active control group in the MFI-20 subscale of physical fatigue (resistance group Δ -1.7, SD 4.3, controls Δ 0.0, SD 2.7, p = 0.013), with an effect size of 0.33. Sleep efficiency was the strongest predictor of change in the MFI-20 subscale general fatigue (beta = -0.54, p = 0.031, R (2) = 0.05). Participating in resistance exercise (beta = 1.90, p = 0.010) and working fewer hours per week (beta = 0.84, p = 0.005) were independent significant predictors of change in physical fatigue (R (2) = 0.14). CONCLUSIONS: Person-centered progressive resistance exercise improved physical fatigue in women with FM when compared to an active control group. TRIAL REGISTRATION: ClinicalTrials.gov NCT01226784 . Registered 21 October 2010. SN - 1478-6362 UR - https://www.unboundmedicine.com/medline/citation/27473164/Resistance_exercise_improves_physical_fatigue_in_women_with_fibromyalgia:_a_randomized_controlled_trial_ L2 - https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1073-3 DB - PRIME DP - Unbound Medicine ER -