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Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease.
Chin J Nat Med. 2016 Jun; 14(6):427-33.CJ

Abstract

Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.

Authors+Show Affiliations

School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China; Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA; Institute for Engaged Aging, Clemson University, Clemson, SC 29634, USA. Electronic address: ydong@clemson.edu.School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. Electronic address: yebp@cpu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27473960

Citation

Guo, Hong, et al. "Cranberry Extract Supplementation Exerts Preventive Effects Through Alleviating Aβ Toxicity in Caenorhabditis Elegans Model of Alzheimer's Disease." Chinese Journal of Natural Medicines, vol. 14, no. 6, 2016, pp. 427-33.
Guo H, Dong YQ, Ye BP. Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease. Chin J Nat Med. 2016;14(6):427-33.
Guo, H., Dong, Y. Q., & Ye, B. P. (2016). Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease. Chinese Journal of Natural Medicines, 14(6), 427-33. https://doi.org/10.1016/S1875-5364(16)30039-5
Guo H, Dong YQ, Ye BP. Cranberry Extract Supplementation Exerts Preventive Effects Through Alleviating Aβ Toxicity in Caenorhabditis Elegans Model of Alzheimer's Disease. Chin J Nat Med. 2016;14(6):427-33. PubMed PMID: 27473960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease. AU - Guo,Hong, AU - Dong,Yu-Qing, AU - Ye,Bo-Ping, PY - 2015/07/01/received PY - 2016/7/31/entrez PY - 2016/7/31/pubmed PY - 2017/2/6/medline KW - Aβ toxicity KW - Body paralysis KW - Caenorhabditis elegans KW - Cranberry polyphenols KW - Prevention SP - 427 EP - 33 JF - Chinese journal of natural medicines JO - Chin J Nat Med VL - 14 IS - 6 N2 - Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals. SN - 1875-5364 UR - https://www.unboundmedicine.com/medline/citation/27473960/Cranberry_extract_supplementation_exerts_preventive_effects_through_alleviating_Aβ_toxicity_in_Caenorhabditis_elegans_model_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-5364(16)30039-5 DB - PRIME DP - Unbound Medicine ER -