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Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial.
Clin Cardiol 2016; 39(8):433-9CC

Abstract

Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent form of heart failure in developed countries. Regrettably, there is no evidence-based effective therapy for HFpEF. We seek to evaluate whether inspiratory muscle training, functional electrical stimulation, or a combination of both can improve exercise capacity as well as left ventricular diastolic function, biomarker profile, quality of life (QoL), and prognosis in patients with HFpEF. A total of 60 stable symptomatic patients with HFpEF (New York Heart Association class II-III/IV) will be randomized (1:1:1:1) to receive a 12-week program of inspiratory muscle training, functional electrical stimulation, a combination of both, or standard care alone. The primary endpoint of the study is change in peak exercise oxygen uptake; secondary endpoints are changes in QoL, echocardiogram parameters, and prognostic biomarkers. As of March 21, 2016, thirty patients have been enrolled. Searching for novel therapies that improve QoL and autonomy in the elderly with HFpEF has become a health care priority. We believe that this study will add important knowledge about the potential utility of 2 simple and feasible physical interventions for the treatment of advanced HFpEF.

Authors+Show Affiliations

Cardiology Department, Hospital de La Plana, Universitat Jaume I, Castellón, Spain.Cardiology Department, Hospital General de Castellón, Universitat Jaume I, Castellón, Spain.Department of Physiotherapy, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.Department of Physiotherapy, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.Cardiology Department, Hospital Clínico Universitario-INCLIVA, Universitat de València, Valencia, Spain.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27481035

Citation

Palau, Patricia, et al. "Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial." Clinical Cardiology, vol. 39, no. 8, 2016, pp. 433-9.
Palau P, Domínguez E, López L, et al. Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial. Clin Cardiol. 2016;39(8):433-9.
Palau, P., Domínguez, E., López, L., Heredia, R., González, J., Ramón, J. M., ... Núñez, J. (2016). Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial. Clinical Cardiology, 39(8), pp. 433-9. doi:10.1002/clc.22555.
Palau P, et al. Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial. Clin Cardiol. 2016;39(8):433-9. PubMed PMID: 27481035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial. AU - Palau,Patricia, AU - Domínguez,Eloy, AU - López,Laura, AU - Heredia,Raquel, AU - González,Jessika, AU - Ramón,Jose María, AU - Serra,Pilar, AU - Santas,Enrique, AU - Bodi,Vicente, AU - Sanchis,Juan, AU - Chorro,Francisco J, AU - Núñez,Julio, Y1 - 2016/08/02/ PY - 2016/02/04/received PY - 2016/04/15/revised PY - 2016/8/3/entrez PY - 2016/8/3/pubmed PY - 2017/3/28/medline SP - 433 EP - 9 JF - Clinical cardiology JO - Clin Cardiol VL - 39 IS - 8 N2 - Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent form of heart failure in developed countries. Regrettably, there is no evidence-based effective therapy for HFpEF. We seek to evaluate whether inspiratory muscle training, functional electrical stimulation, or a combination of both can improve exercise capacity as well as left ventricular diastolic function, biomarker profile, quality of life (QoL), and prognosis in patients with HFpEF. A total of 60 stable symptomatic patients with HFpEF (New York Heart Association class II-III/IV) will be randomized (1:1:1:1) to receive a 12-week program of inspiratory muscle training, functional electrical stimulation, a combination of both, or standard care alone. The primary endpoint of the study is change in peak exercise oxygen uptake; secondary endpoints are changes in QoL, echocardiogram parameters, and prognostic biomarkers. As of March 21, 2016, thirty patients have been enrolled. Searching for novel therapies that improve QoL and autonomy in the elderly with HFpEF has become a health care priority. We believe that this study will add important knowledge about the potential utility of 2 simple and feasible physical interventions for the treatment of advanced HFpEF. SN - 1932-8737 UR - https://www.unboundmedicine.com/medline/citation/27481035/Inspiratory_Muscle_Training_and_Functional_Electrical_Stimulation_for_Treatment_of_Heart_Failure_With_Preserved_Ejection_Fraction:_Rationale_and_Study_Design_of_a_Prospective_Randomized_Controlled_Trial_ L2 - https://doi.org/10.1002/clc.22555 DB - PRIME DP - Unbound Medicine ER -