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Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice.
Neurobiol Learn Mem. 2016 10; 134 Pt B:264-74.NL

Abstract

The cannabinoid system plays an important role in memory processes, many studies have indicated that cannabinoid receptor ligands have ability to modulate memory in rodents. A nonapeptide hemopressin (Hp) derived from rat brain, acts as a peptide antagonist or selective inverse peptide agonist of cannabinoid 1 (CB1) receptor. N-terminally extended forms of Hp isolated from mouse brain, (m)RVD-hemopressin(α) (RVD) and (m)VD-hemopressin(α) (VD) also bind CB1 receptor, however, as peptide agonists. Here, we investigated the roles of Hp, RVD, and VD on memory in mice using novel object recognition (NOR) and object location recognition (OLR) tasks. In normal young mice, intracerebroventricular (i.c.v.) infusion of Hp before training not only improved memory formation, but also prolonged memory retention in the tasks, these effects could be inhibited by RVD or VD at the same dose and intraperitoneal (i.p.) injection of a small molecule agonist of CB1 receptor WIN55, 212-2 15min before administration of Hp inhibited the memory-improving effect of Hp. In addition, under the same experimental conditions, i.c.v. RVD or VD displayed memory-impairing effects, which could be prevented by Hp (i.c.v.) or AM251 (i.p.), a small molecule antagonist of CB1 receptor. Infusion of amyloid-β (1-42) (Aβ1-42) 14days before training resulted in impairment of memory in mice which could be used as animal model of Alzheimer's disease (AD). In these mice, RVD or VD (i.c.v.) reversed the memory impairment induced by Aβ1-42, and the effects of RVD and VD could be suppressed by Hp (i.c.v.) or AM251 (2mg/kg, i.p.). Separate administration of Hp had no effect in Aβ1-42-treated mice. The above results suggested that Hp, RVD and VD, as CB1 receptor peptide ligands, may be potential drugs to treatment of the memory deficit-involving disease, just as AD.

Authors+Show Affiliations

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Xi'an Medical University, Xi'an, China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China. Electronic address: wangrui@lzu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27481221

Citation

Zhang, Rui-San, et al. "Effects of the Cannabinoid 1 Receptor Peptide Ligands Hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) On Memory in Novel Object and Object Location Recognition Tasks in Normal Young and Aβ1-42-treated Mice." Neurobiology of Learning and Memory, vol. 134 Pt B, 2016, pp. 264-74.
Zhang RS, He Z, Jin WD, et al. Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice. Neurobiol Learn Mem. 2016;134 Pt B:264-74.
Zhang, R. S., He, Z., Jin, W. D., & Wang, R. (2016). Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice. Neurobiology of Learning and Memory, 134 Pt B, 264-74. https://doi.org/10.1016/j.nlm.2016.07.030
Zhang RS, et al. Effects of the Cannabinoid 1 Receptor Peptide Ligands Hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) On Memory in Novel Object and Object Location Recognition Tasks in Normal Young and Aβ1-42-treated Mice. Neurobiol Learn Mem. 2016;134 Pt B:264-74. PubMed PMID: 27481221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice. AU - Zhang,Rui-San, AU - He,Zhen, AU - Jin,Wei-Dong, AU - Wang,Rui, Y1 - 2016/07/30/ PY - 2015/09/29/received PY - 2016/05/25/revised PY - 2016/07/28/accepted PY - 2016/8/3/entrez PY - 2016/8/3/pubmed PY - 2018/2/10/medline KW - (m)RVD-hemopressin(α) KW - (m)VD-hemopressin(α) KW - Alzheimer’s disease KW - Cannabinoid receptor KW - Hemopressin KW - Recognition memory SP - 264 EP - 74 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 134 Pt B N2 - The cannabinoid system plays an important role in memory processes, many studies have indicated that cannabinoid receptor ligands have ability to modulate memory in rodents. A nonapeptide hemopressin (Hp) derived from rat brain, acts as a peptide antagonist or selective inverse peptide agonist of cannabinoid 1 (CB1) receptor. N-terminally extended forms of Hp isolated from mouse brain, (m)RVD-hemopressin(α) (RVD) and (m)VD-hemopressin(α) (VD) also bind CB1 receptor, however, as peptide agonists. Here, we investigated the roles of Hp, RVD, and VD on memory in mice using novel object recognition (NOR) and object location recognition (OLR) tasks. In normal young mice, intracerebroventricular (i.c.v.) infusion of Hp before training not only improved memory formation, but also prolonged memory retention in the tasks, these effects could be inhibited by RVD or VD at the same dose and intraperitoneal (i.p.) injection of a small molecule agonist of CB1 receptor WIN55, 212-2 15min before administration of Hp inhibited the memory-improving effect of Hp. In addition, under the same experimental conditions, i.c.v. RVD or VD displayed memory-impairing effects, which could be prevented by Hp (i.c.v.) or AM251 (i.p.), a small molecule antagonist of CB1 receptor. Infusion of amyloid-β (1-42) (Aβ1-42) 14days before training resulted in impairment of memory in mice which could be used as animal model of Alzheimer's disease (AD). In these mice, RVD or VD (i.c.v.) reversed the memory impairment induced by Aβ1-42, and the effects of RVD and VD could be suppressed by Hp (i.c.v.) or AM251 (2mg/kg, i.p.). Separate administration of Hp had no effect in Aβ1-42-treated mice. The above results suggested that Hp, RVD and VD, as CB1 receptor peptide ligands, may be potential drugs to treatment of the memory deficit-involving disease, just as AD. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/27481221/Effects_of_the_cannabinoid_1_receptor_peptide_ligands_hemopressin__m_RVD_hemopressin_α__and__m_VD_hemopressin_α__on_memory_in_novel_object_and_object_location_recognition_tasks_in_normal_young_and_Aβ1_42_treated_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(16)30130-7 DB - PRIME DP - Unbound Medicine ER -