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Association Between Vitamin D Deficiency and Outcomes Following Spinal Fusion Surgery: A Systematic Review.
World Neurosurg 2016; 95:71-76WN

Abstract

BACKGROUND

Vitamin D deficiency is a relatively common occurrence in patients presenting for spinal surgery; however, whether this abnormality has any effect on spinal fusion outcomes remains unclear. We performed a systematic review of the available literature relevant to the association between vitamin D deficiency and spinal fusion outcomes.

METHODS

We conducted a systematic and critical review of recent literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following databases were searched: MEDLINE/PubMed, Google Scholar, Cochrane, Web of Science, and Scopus. Key search terms were "vitamin D," "spinal surgery outcomes," "spinal fusion," and "pseudarthrosis." Papers included in the review were original research articles in peer-reviewed journals. The articles were thoroughly examined and compared on the basis of study design, outcomes, and results.

RESULTS

A total of 5 studies were included in the qualitative analysis. In these studies, patients presenting with vitamin D deficiency achieved lower fusion rates and suffered higher rates of recurrent-persistent low back pain compared with patients with normal vitamin D levels. Studies examining the effect of postoperative vitamin D supplementation in deficient patients reported significant improvements in low back pain intensity, patient-reported outcomes scores, and fusion rates compared with baseline as well as with control groups.

CONCLUSIONS

The literature suggests that patients presenting for spinal fusion may benefit from correction of vitamin D deficiency to maximize the chance of a successful arthrodesis and to achieve optimal surgical outcomes. Future prospective studies are needed to determine whether routine preoperative treatment of this metabolic derangement is warranted.

Authors+Show Affiliations

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, Minnesota, USA.Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, Minnesota, USA.Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA; Neuro-Informatics Laboratory, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: Bydon.mohamad@mayo.edu.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

27481599

Citation

Kerezoudis, Panagiotis, et al. "Association Between Vitamin D Deficiency and Outcomes Following Spinal Fusion Surgery: a Systematic Review." World Neurosurgery, vol. 95, 2016, pp. 71-76.
Kerezoudis P, Rinaldo L, Drazin D, et al. Association Between Vitamin D Deficiency and Outcomes Following Spinal Fusion Surgery: A Systematic Review. World Neurosurg. 2016;95:71-76.
Kerezoudis, P., Rinaldo, L., Drazin, D., Kallmes, D., Krauss, W., Hassoon, A., & Bydon, M. (2016). Association Between Vitamin D Deficiency and Outcomes Following Spinal Fusion Surgery: A Systematic Review. World Neurosurgery, 95, pp. 71-76. doi:10.1016/j.wneu.2016.07.074.
Kerezoudis P, et al. Association Between Vitamin D Deficiency and Outcomes Following Spinal Fusion Surgery: a Systematic Review. World Neurosurg. 2016;95:71-76. PubMed PMID: 27481599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between Vitamin D Deficiency and Outcomes Following Spinal Fusion Surgery: A Systematic Review. AU - Kerezoudis,Panagiotis, AU - Rinaldo,Lorenzo, AU - Drazin,Doniel, AU - Kallmes,David, AU - Krauss,William, AU - Hassoon,Ahmed, AU - Bydon,Mohamad, Y1 - 2016/07/30/ PY - 2016/06/18/received PY - 2016/07/19/revised PY - 2016/07/20/accepted PY - 2016/8/3/pubmed PY - 2017/10/3/medline PY - 2016/8/3/entrez KW - Osteomalacia KW - Pseudarthrosis KW - Spinal fusion KW - Spinal surgery KW - Surgical outcomes KW - Vitamin D deficiency SP - 71 EP - 76 JF - World neurosurgery JO - World Neurosurg VL - 95 N2 - BACKGROUND: Vitamin D deficiency is a relatively common occurrence in patients presenting for spinal surgery; however, whether this abnormality has any effect on spinal fusion outcomes remains unclear. We performed a systematic review of the available literature relevant to the association between vitamin D deficiency and spinal fusion outcomes. METHODS: We conducted a systematic and critical review of recent literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following databases were searched: MEDLINE/PubMed, Google Scholar, Cochrane, Web of Science, and Scopus. Key search terms were "vitamin D," "spinal surgery outcomes," "spinal fusion," and "pseudarthrosis." Papers included in the review were original research articles in peer-reviewed journals. The articles were thoroughly examined and compared on the basis of study design, outcomes, and results. RESULTS: A total of 5 studies were included in the qualitative analysis. In these studies, patients presenting with vitamin D deficiency achieved lower fusion rates and suffered higher rates of recurrent-persistent low back pain compared with patients with normal vitamin D levels. Studies examining the effect of postoperative vitamin D supplementation in deficient patients reported significant improvements in low back pain intensity, patient-reported outcomes scores, and fusion rates compared with baseline as well as with control groups. CONCLUSIONS: The literature suggests that patients presenting for spinal fusion may benefit from correction of vitamin D deficiency to maximize the chance of a successful arthrodesis and to achieve optimal surgical outcomes. Future prospective studies are needed to determine whether routine preoperative treatment of this metabolic derangement is warranted. SN - 1878-8769 UR - https://www.unboundmedicine.com/medline/citation/27481599/Association_Between_Vitamin_D_Deficiency_and_Outcomes_Following_Spinal_Fusion_Surgery:_A_Systematic_Review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-8750(16)30618-0 DB - PRIME DP - Unbound Medicine ER -