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Impulse Oscillometry and Spirometry Small-Airway Parameters in Mild to Moderate Bronchiectasis.
Respir Care 2016; 61(11):1513-1522RC

Abstract

BACKGROUND

Both impulse oscillometry and spirometry can reflect small-airway disorders. The objective of this work was to investigate the diagnostic value of impulse oscillometry and spirometry small-airway parameters and their correlation with radiology, disease severity, and sputum bacteriology in mild to moderate bronchiectasis (bronchiectasis severity index <9) and to validate these findings in sensitivity analyses (mild bronchiectasis).

METHODS

We recruited 94 subjects with mild to moderate bronchiectasis and 26 healthy subjects. The diagnostic value of small-airway parameters was compared using the receiver operating characteristic curve. Chest high-resolution computed tomography (HRCT), impulse oscillometry measurement, spirometry, and sputum culture were performed. Correlation between small-airway parameters and clinical indices was determined, adjusting for age, sex, body mass index, and smoking history. Sensitivity analyses were repeated when excluding subjects with bronchiectasis severity index ≥9 or HRCT score ≥13.

RESULTS

Impulse oscillometry and spirometry small-airway parameters could discriminate mild to moderate bronchiectasis from healthy subjects and correlated significantly with HRCT score and the number of bronchiectatic lobes and the bronchiectasis severity index (all P < .01). Small-airway parameters were more aberrant in subjects with dyshomogeneity and cystic bronchiectasis but were independent of Pseudomonas aeruginosa isolation or the location of predominant bronchiectatic lobes. Spirometry, but not impulse oscillometry, small-airway parameters differed statistically between subjects with isolated peripheral-airway bronchiectasis and those with peripheral plus central-airway bronchiectasis (all P < .01). Subgroup analyses yielded similar findings, except for the lack of correlation between small-airway parameters and clinical parameters in subjects with HRCT score ≤6.

CONCLUSIONS

Impulse oscillometry and spirometry small-airway parameters have similar diagnostic value in reflecting peripheral-airway disorders and correlate with the HRCT scores, the bronchiectasis severity index, and the number of bronchiectatic lobes in mild to moderate bronchiectasis. Assessment of small-airway parameters should be incorporated in future lung function investigations in bronchiectasis.

Authors+Show Affiliations

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China. nanshan@vip.163.com chenrc@vip.163.com.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China. nanshan@vip.163.com chenrc@vip.163.com.

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

27484107

Citation

Guan, Wei-Jie, et al. "Impulse Oscillometry and Spirometry Small-Airway Parameters in Mild to Moderate Bronchiectasis." Respiratory Care, vol. 61, no. 11, 2016, pp. 1513-1522.
Guan WJ, Yuan JJ, Gao YH, et al. Impulse Oscillometry and Spirometry Small-Airway Parameters in Mild to Moderate Bronchiectasis. Respir Care. 2016;61(11):1513-1522.
Guan, W. J., Yuan, J. J., Gao, Y. H., Li, H. M., Zheng, J. P., Chen, R. C., & Zhong, N. S. (2016). Impulse Oscillometry and Spirometry Small-Airway Parameters in Mild to Moderate Bronchiectasis. Respiratory Care, 61(11), pp. 1513-1522.
Guan WJ, et al. Impulse Oscillometry and Spirometry Small-Airway Parameters in Mild to Moderate Bronchiectasis. Respir Care. 2016;61(11):1513-1522. PubMed PMID: 27484107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impulse Oscillometry and Spirometry Small-Airway Parameters in Mild to Moderate Bronchiectasis. AU - Guan,Wei-Jie, AU - Yuan,Jing-Jing, AU - Gao,Yong-Hua, AU - Li,Hui-Min, AU - Zheng,Jin-Ping, AU - Chen,Rong-Chang, AU - Zhong,Nan-Shan, Y1 - 2016/08/02/ PY - 2016/10/30/pubmed PY - 2017/9/1/medline PY - 2016/8/4/entrez KW - bronchiectasis KW - bronchiectasis severity index KW - impulse oscillometry KW - small-airway parameter KW - spirometry SP - 1513 EP - 1522 JF - Respiratory care JO - Respir Care VL - 61 IS - 11 N2 - BACKGROUND: Both impulse oscillometry and spirometry can reflect small-airway disorders. The objective of this work was to investigate the diagnostic value of impulse oscillometry and spirometry small-airway parameters and their correlation with radiology, disease severity, and sputum bacteriology in mild to moderate bronchiectasis (bronchiectasis severity index <9) and to validate these findings in sensitivity analyses (mild bronchiectasis). METHODS: We recruited 94 subjects with mild to moderate bronchiectasis and 26 healthy subjects. The diagnostic value of small-airway parameters was compared using the receiver operating characteristic curve. Chest high-resolution computed tomography (HRCT), impulse oscillometry measurement, spirometry, and sputum culture were performed. Correlation between small-airway parameters and clinical indices was determined, adjusting for age, sex, body mass index, and smoking history. Sensitivity analyses were repeated when excluding subjects with bronchiectasis severity index ≥9 or HRCT score ≥13. RESULTS: Impulse oscillometry and spirometry small-airway parameters could discriminate mild to moderate bronchiectasis from healthy subjects and correlated significantly with HRCT score and the number of bronchiectatic lobes and the bronchiectasis severity index (all P < .01). Small-airway parameters were more aberrant in subjects with dyshomogeneity and cystic bronchiectasis but were independent of Pseudomonas aeruginosa isolation or the location of predominant bronchiectatic lobes. Spirometry, but not impulse oscillometry, small-airway parameters differed statistically between subjects with isolated peripheral-airway bronchiectasis and those with peripheral plus central-airway bronchiectasis (all P < .01). Subgroup analyses yielded similar findings, except for the lack of correlation between small-airway parameters and clinical parameters in subjects with HRCT score ≤6. CONCLUSIONS: Impulse oscillometry and spirometry small-airway parameters have similar diagnostic value in reflecting peripheral-airway disorders and correlate with the HRCT scores, the bronchiectasis severity index, and the number of bronchiectatic lobes in mild to moderate bronchiectasis. Assessment of small-airway parameters should be incorporated in future lung function investigations in bronchiectasis. SN - 1943-3654 UR - https://www.unboundmedicine.com/medline/citation/27484107/Impulse_Oscillometry_and_Spirometry_Small_Airway_Parameters_in_Mild_to_Moderate_Bronchiectasis_ L2 - http://rc.rcjournal.com/cgi/pmidlookup?view=short&amp;pmid=27484107 DB - PRIME DP - Unbound Medicine ER -