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Hydrogen polysulfide (H2S n) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO).
J Neural Transm (Vienna). 2016 11; 123(11):1235-1245.JN

Abstract

Hydrogen sulfide (H2S) is a physiological mediator with various roles, including neuro-modulation, vascular tone regulation, and cytoprotection against ischemia-reperfusion injury, angiogenesis, and oxygen sensing. Hydrogen polysulfide (H2S n), which possesses a higher number of sulfur atoms than H2S, recently emerged as a potential signaling molecule that regulates the activity of ion channels, a tumor suppressor, transcription factors, and protein kinases. Some of the previously reported effects of H2S are now attributed to the more potent H2S n . H2S n is produced by 3-mercaptopyruvate sulfurtransferase (3MST) from 3-mercaptopyruvate (3MP) and is generated by the chemical interaction of H2S with nitric oxide (NO). H2S n sulfhydrates (sulfurates) cysteine residues of target proteins and modifies their activity, whereas H2S sulfurates oxidized cysteine residues as well as reduces cysteine disulfide bonds. This review focuses on the recent progress made in studies concerning the production and physiological roles of H2S n and H2S.

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Authors+Show Affiliations

Kimura H
Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. kimura@ncnp.go.jp.

MeSH

AnimalsHumansHydrogen SulfideNitric OxideSignal TransductionSulfur CompoundsSulfurtransferases

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27484215

Citation

Kimura, Hideo. "Hydrogen Polysulfide (H2S N) Signaling Along With Hydrogen Sulfide (H2S) and Nitric Oxide (NO)." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 123, no. 11, 2016, pp. 1235-1245.
Kimura H. Hydrogen polysulfide (H2S n) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO). J Neural Transm (Vienna). 2016;123(11):1235-1245.
Kimura, H. (2016). Hydrogen polysulfide (H2S n) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO). Journal of Neural Transmission (Vienna, Austria : 1996), 123(11), 1235-1245.
Kimura H. Hydrogen Polysulfide (H2S N) Signaling Along With Hydrogen Sulfide (H2S) and Nitric Oxide (NO). J Neural Transm (Vienna). 2016;123(11):1235-1245. PubMed PMID: 27484215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen polysulfide (H2S n) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO). A1 - Kimura,Hideo, Y1 - 2016/08/02/ PY - 2016/06/29/received PY - 2016/07/19/accepted PY - 2016/8/4/pubmed PY - 2018/1/19/medline PY - 2016/8/4/entrez KW - 3MST KW - H2S KW - H2S n KW - NO KW - Rhodanese KW - Signaling SP - 1235 EP - 1245 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 123 IS - 11 N2 - Hydrogen sulfide (H2S) is a physiological mediator with various roles, including neuro-modulation, vascular tone regulation, and cytoprotection against ischemia-reperfusion injury, angiogenesis, and oxygen sensing. Hydrogen polysulfide (H2S n), which possesses a higher number of sulfur atoms than H2S, recently emerged as a potential signaling molecule that regulates the activity of ion channels, a tumor suppressor, transcription factors, and protein kinases. Some of the previously reported effects of H2S are now attributed to the more potent H2S n . H2S n is produced by 3-mercaptopyruvate sulfurtransferase (3MST) from 3-mercaptopyruvate (3MP) and is generated by the chemical interaction of H2S with nitric oxide (NO). H2S n sulfhydrates (sulfurates) cysteine residues of target proteins and modifies their activity, whereas H2S sulfurates oxidized cysteine residues as well as reduces cysteine disulfide bonds. This review focuses on the recent progress made in studies concerning the production and physiological roles of H2S n and H2S. SN - 1435-1463 UR - https://www.unboundmedicine.com/medline/citation/27484215/Hydrogen_polysulfide__H2S_n__signaling_along_with_hydrogen_sulfide__H2S__and_nitric_oxide__NO__ L2 - https://doi.org/10.1007/s00702-016-1600-z DB - PRIME DP - Unbound Medicine ER -