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Role of bioactive fatty acids in nonalcoholic fatty liver disease.
Nutr J 2016; 15(1):72NJ

Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. In contrast, polyunsaturated fatty acids exhibit antiobesity, anti steatosic and anti-inflammatory effects. The combination of these forms of fatty acids-according to dietary type, daily intake and the proportion of n-6 to n-3 fats-can compromise hepatic lipid metabolism. A chemosensory rather than a nutritional role makes bioactive fatty acids possible biomarkers for NAFLD. Bioactive fatty acids provide health benefits through modification of fatty acid composition and modulating the activity of liver cells during liver fibrosis. More and better evidence is necessary to elucidate the role of bioactive fatty acids in nutritional and clinical treatment strategies for patients with NAFLD.

Authors+Show Affiliations

Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico.Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico.Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico. Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico.Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico. vbarberob@medicasur.org.mx.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27485440

Citation

Juárez-Hernández, Eva, et al. "Role of Bioactive Fatty Acids in Nonalcoholic Fatty Liver Disease." Nutrition Journal, vol. 15, no. 1, 2016, p. 72.
Juárez-Hernández E, Chávez-Tapia NC, Uribe M, et al. Role of bioactive fatty acids in nonalcoholic fatty liver disease. Nutr J. 2016;15(1):72.
Juárez-Hernández, E., Chávez-Tapia, N. C., Uribe, M., & Barbero-Becerra, V. J. (2016). Role of bioactive fatty acids in nonalcoholic fatty liver disease. Nutrition Journal, 15(1), p. 72. doi:10.1186/s12937-016-0191-8.
Juárez-Hernández E, et al. Role of Bioactive Fatty Acids in Nonalcoholic Fatty Liver Disease. Nutr J. 2016 08 2;15(1):72. PubMed PMID: 27485440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of bioactive fatty acids in nonalcoholic fatty liver disease. AU - Juárez-Hernández,Eva, AU - Chávez-Tapia,Norberto C, AU - Uribe,Misael, AU - Barbero-Becerra,Varenka J, Y1 - 2016/08/02/ PY - 2016/02/17/received PY - 2016/07/20/accepted PY - 2016/8/4/entrez PY - 2016/8/4/pubmed PY - 2017/10/11/medline KW - Fatty acids KW - Liver diseases KW - Nutrition KW - Risk factors SP - 72 EP - 72 JF - Nutrition journal JO - Nutr J VL - 15 IS - 1 N2 - Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. In contrast, polyunsaturated fatty acids exhibit antiobesity, anti steatosic and anti-inflammatory effects. The combination of these forms of fatty acids-according to dietary type, daily intake and the proportion of n-6 to n-3 fats-can compromise hepatic lipid metabolism. A chemosensory rather than a nutritional role makes bioactive fatty acids possible biomarkers for NAFLD. Bioactive fatty acids provide health benefits through modification of fatty acid composition and modulating the activity of liver cells during liver fibrosis. More and better evidence is necessary to elucidate the role of bioactive fatty acids in nutritional and clinical treatment strategies for patients with NAFLD. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/27485440/Role_of_bioactive_fatty_acids_in_nonalcoholic_fatty_liver_disease_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0191-8 DB - PRIME DP - Unbound Medicine ER -