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Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine.
Neuropsychiatr Dis Treat. 2016; 12:1779-85.ND

Abstract

Migraine is one of the most common neurological diseases worldwide. Migraine pathophysiology is very complex. Genetic factors play a major role in migraine. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), play an important role in central nervous system functioning, development, and modulation of pain. This study investigates whether polymorphisms in the BDNF and NGF genes are associated with migraine disease in a Turkish case-control population. Overall, 576 subjects were investigated (288 patients with migraine and 288 healthy controls) for the following polymorphisms: rs6265(G/A), rs8192466(C/T), rs925946(G/T), rs2049046(A/T), and rs12273363(T/C) in the BDNF gene, and rs6330(C/T), rs11466112(C/T), rs11102930(C/A), and rs4839435(G/A) in the NGF gene using 5'-exonuclease allelic discrimination assays. We found no differences in frequency of the analyzed eight polymorphisms between migraine and control groups. However, the frequency of minor A alleles of rs6265 in BDNF gene was borderline significant in the patients compared with the healthy controls (P=0.049; odds ratios [ORs] [95% confidence intervals {CIs}] =0.723 [0.523-0.999]). Moreover, when the migraine patients were divided into two subgroups, migraine with aura (MA) and migraine without aura (MO), the minor TT genotype of rs6330 in NGF was significantly higher in MA patients than in MO patients (P=0.036) or healthy controls (P=0.026), and this disappeared after correction for multiple testing. Also, the rs6330*T minor allele was more common in the MA group than in the MO group or controls (P=0.011, ORs [95% CIs] =1.626 [1.117-2.365] or P=0.007, ORs [95% CIs] =1.610 [1.140-2.274], respectively). In conclusion, this is the first clinical study to evaluate the association between BDNF and NGF polymorphisms in migraine patients compared with health controls. Our findings suggest that the NGF rs6330*T minor allele might be nominated as a risk factor for developing aura in migraine disease. Our results should be considered as preliminary, and they need to be confirmed by future studies.

Authors+Show Affiliations

Department of Medical Genetics.Department of Neurology.Department of Neurology.Department of Obstetrics and Gynecology, Medical Faculty, Dicle University, Diyarbakır, Turkey.Department of Neurology, Diyarbakır Education and Research Hospital, Diyarbakır, Turkey.Department of Neurology, Elazığ Education and Research Hospital, Elazığ, Turkey.Department of Psychiatry, Afsin State Hospital, Kahramanmaras, Turkey.Laboratory of Molecular Genetics, Medical Faculty, Dicle University, Diyarbakır, Turkey.Department of Neurology.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27486327

Citation

Coskun, Salih, et al. "Association of Brain-derived Neurotrophic Factor and Nerve Growth Factor Gene Polymorphisms With Susceptibility to Migraine." Neuropsychiatric Disease and Treatment, vol. 12, 2016, pp. 1779-85.
Coskun S, Varol S, Ozdemir HH, et al. Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine. Neuropsychiatr Dis Treat. 2016;12:1779-85.
Coskun, S., Varol, S., Ozdemir, H. H., Agacayak, E., Aydın, B., Kapan, O., Camkurt, M. A., Tunc, S., & Cevik, M. U. (2016). Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine. Neuropsychiatric Disease and Treatment, 12, 1779-85. https://doi.org/10.2147/NDT.S108814
Coskun S, et al. Association of Brain-derived Neurotrophic Factor and Nerve Growth Factor Gene Polymorphisms With Susceptibility to Migraine. Neuropsychiatr Dis Treat. 2016;12:1779-85. PubMed PMID: 27486327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine. AU - Coskun,Salih, AU - Varol,Sefer, AU - Ozdemir,Hasan H, AU - Agacayak,Elif, AU - Aydın,Birsen, AU - Kapan,Oktay, AU - Camkurt,Mehmet Akif, AU - Tunc,Saban, AU - Cevik,Mehmet Ugur, Y1 - 2016/07/19/ PY - 2016/8/4/entrez PY - 2016/8/4/pubmed PY - 2016/8/4/medline KW - aura KW - brain-derived neurotrophic factor KW - headache KW - migraine KW - migraine with aura KW - nerve growth factor KW - polymorphism SP - 1779 EP - 85 JF - Neuropsychiatric disease and treatment JO - Neuropsychiatr Dis Treat VL - 12 N2 - Migraine is one of the most common neurological diseases worldwide. Migraine pathophysiology is very complex. Genetic factors play a major role in migraine. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), play an important role in central nervous system functioning, development, and modulation of pain. This study investigates whether polymorphisms in the BDNF and NGF genes are associated with migraine disease in a Turkish case-control population. Overall, 576 subjects were investigated (288 patients with migraine and 288 healthy controls) for the following polymorphisms: rs6265(G/A), rs8192466(C/T), rs925946(G/T), rs2049046(A/T), and rs12273363(T/C) in the BDNF gene, and rs6330(C/T), rs11466112(C/T), rs11102930(C/A), and rs4839435(G/A) in the NGF gene using 5'-exonuclease allelic discrimination assays. We found no differences in frequency of the analyzed eight polymorphisms between migraine and control groups. However, the frequency of minor A alleles of rs6265 in BDNF gene was borderline significant in the patients compared with the healthy controls (P=0.049; odds ratios [ORs] [95% confidence intervals {CIs}] =0.723 [0.523-0.999]). Moreover, when the migraine patients were divided into two subgroups, migraine with aura (MA) and migraine without aura (MO), the minor TT genotype of rs6330 in NGF was significantly higher in MA patients than in MO patients (P=0.036) or healthy controls (P=0.026), and this disappeared after correction for multiple testing. Also, the rs6330*T minor allele was more common in the MA group than in the MO group or controls (P=0.011, ORs [95% CIs] =1.626 [1.117-2.365] or P=0.007, ORs [95% CIs] =1.610 [1.140-2.274], respectively). In conclusion, this is the first clinical study to evaluate the association between BDNF and NGF polymorphisms in migraine patients compared with health controls. Our findings suggest that the NGF rs6330*T minor allele might be nominated as a risk factor for developing aura in migraine disease. Our results should be considered as preliminary, and they need to be confirmed by future studies. SN - 1176-6328 UR - https://www.unboundmedicine.com/medline/citation/27486327/Association_of_brain_derived_neurotrophic_factor_and_nerve_growth_factor_gene_polymorphisms_with_susceptibility_to_migraine_ L2 - https://dx.doi.org/10.2147/NDT.S108814 DB - PRIME DP - Unbound Medicine ER -
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