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Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection.
J Med Virol. 2017 03; 89(3):542-545.JM

Abstract

The spike glycoprotein of the Middle East respiratory coronavirus (MERS-CoV) facilitates receptor binding and cell entry. During investigation of a multi-facility outbreak of MERS-CoV in Taif, Saudi Arabia, we identified a mixed population of wild-type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERS-CoV present as a quasispecies. J. Med. Virol. 89:542-545, 2017. © 2016 Wiley Periodicals, Inc.

Authors+Show Affiliations

Centers for Disease Control and Prevention, Atlanta, Georgia.Centers for Disease Control and Prevention, Atlanta, Georgia.Centers for Disease Control and Prevention, Atlanta, Georgia.Centers for Disease Control and Prevention, Atlanta, Georgia.Centers for Disease Control and Prevention, Atlanta, Georgia.Ministry of Health, Riyadh, Saudi Arabia.Ministry of Health, Riyadh, Saudi Arabia.Ministry of Health, Riyadh, Saudi Arabia.Centers for Disease Control and Prevention, Atlanta, Georgia.Ministry of Health, Riyadh, Saudi Arabia.Centers for Disease Control and Prevention, Atlanta, Georgia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27486688

Citation

Lu, Xiaoyan, et al. "Spike Gene Deletion Quasispecies in Serum of Patient With Acute MERS-CoV Infection." Journal of Medical Virology, vol. 89, no. 3, 2017, pp. 542-545.
Lu X, Rowe LA, Frace M, et al. Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection. J Med Virol. 2017;89(3):542-545.
Lu, X., Rowe, L. A., Frace, M., Stevens, J., Abedi, G. R., Elnile, O., Banassir, T., Al-Masri, M., Watson, J. T., Assiri, A., & Erdman, D. D. (2017). Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection. Journal of Medical Virology, 89(3), 542-545. https://doi.org/10.1002/jmv.24652
Lu X, et al. Spike Gene Deletion Quasispecies in Serum of Patient With Acute MERS-CoV Infection. J Med Virol. 2017;89(3):542-545. PubMed PMID: 27486688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection. AU - Lu,Xiaoyan, AU - Rowe,Lori A, AU - Frace,Michael, AU - Stevens,James, AU - Abedi,Glen R, AU - Elnile,Osman, AU - Banassir,Taleb, AU - Al-Masri,Malak, AU - Watson,John T, AU - Assiri,Abdullah, AU - Erdman,Dean D, Y1 - 2016/08/22/ PY - 2016/07/10/accepted PY - 2016/8/4/pubmed PY - 2017/9/8/medline PY - 2016/8/4/entrez KW - MERS-CoV KW - coronavirus KW - genome KW - spike gene SP - 542 EP - 545 JF - Journal of medical virology JO - J Med Virol VL - 89 IS - 3 N2 - The spike glycoprotein of the Middle East respiratory coronavirus (MERS-CoV) facilitates receptor binding and cell entry. During investigation of a multi-facility outbreak of MERS-CoV in Taif, Saudi Arabia, we identified a mixed population of wild-type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERS-CoV present as a quasispecies. J. Med. Virol. 89:542-545, 2017. © 2016 Wiley Periodicals, Inc. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/27486688/Spike_gene_deletion_quasispecies_in_serum_of_patient_with_acute_MERS_CoV_infection_ L2 - https://doi.org/10.1002/jmv.24652 DB - PRIME DP - Unbound Medicine ER -