Tags

Type your tag names separated by a space and hit enter

Mediterranean diet score and left ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis.
Am J Clin Nutr 2016; 104(3):595-602AJ

Abstract

BACKGROUND

Data are limited on the relation between dietary patterns and left ventricular (LV) structure and function.

OBJECTIVE

We examined cross-sectional associations of a diet-score assessment of a Mediterranean dietary pattern with LV mass, volume, mass-to-volume ratio, stroke volume, and ejection fraction.

DESIGN

We measured LV variables with the use of cardiac MRI in 4497 participants in the Multi-Ethnic Study of Atherosclerosis study who were aged 45-84 y and without clinical cardiovascular disease. We calculated a Mediterranean diet score from intakes of fruit, vegetables, nuts, legumes, whole grains, fish, red meat, the monounsaturated fat:saturated fat ratio, and alcohol that were self-reported with the use of a food-frequency questionnaire. We used linear regression with adjustment for body size, physical activity, and cardiovascular disease risk factors to model associations and assess the shape of these associations (linear or quadratic).

RESULTS

The Mediterranean diet score had a slight U-shaped association with LV mass (adjusted means: 146, 145, 146, and 147 g across quartiles of diet score, respectively; P-quadratic trend = 0.04). The score was linearly associated with LV volume, stroke volume, and ejection fraction: for each +1-U difference in score, LV volume was 0.4 mL higher (95% CI: 0.0, 0.8 mL higher), the stroke volume was 0.5 mL higher (95% CI: 0.2, 0.8 mL higher), and the ejection fraction was 0.2 percentage points higher (95% CI: 0.1, 0.3 percentage points higher). The score was not associated with the mass-to-volume ratio.

CONCLUSIONS

A higher Mediterranean diet score is cross-sectionally associated with a higher LV mass, which is balanced by a higher LV volume as well as a higher ejection fraction and stroke volume. Participants in this healthy, multiethnic sample whose dietary patterns most closely conformed to a Mediterranean-type pattern had a modestly better LV structure and function than did participants with less-Mediterranean-like dietary patterns. This trial was registered at clinicaltrials.gov as NCT00005487.

Authors+Show Affiliations

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL; elevitan@uab.edu.Center for Health and Aging, Washington DC VA Medical Center, Washington, DC;College of Public Health, University of Kentucky, Lexington, KY;Department of Radiology, Tufts University School of Medicine, Boston, MA;Departments of Internal Medicine (Cardiology) and Radiology, Wake Forest University School of Medicine, Winston-Salem, NC;NIH Clinical Center, NIH, Bethesda, MD;Department of Epidemiology, University of Washington, Seattle, WA;Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN; and.Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center-Houston, Houston, TX.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

27488238

Citation

Levitan, Emily B., et al. "Mediterranean Diet Score and Left Ventricular Structure and Function: the Multi-Ethnic Study of Atherosclerosis." The American Journal of Clinical Nutrition, vol. 104, no. 3, 2016, pp. 595-602.
Levitan EB, Ahmed A, Arnett DK, et al. Mediterranean diet score and left ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2016;104(3):595-602.
Levitan, E. B., Ahmed, A., Arnett, D. K., Polak, J. F., Hundley, W. G., Bluemke, D. A., ... Nettleton, J. A. (2016). Mediterranean diet score and left ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis. The American Journal of Clinical Nutrition, 104(3), pp. 595-602. doi:10.3945/ajcn.115.128579.
Levitan EB, et al. Mediterranean Diet Score and Left Ventricular Structure and Function: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2016;104(3):595-602. PubMed PMID: 27488238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet score and left ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis. AU - Levitan,Emily B, AU - Ahmed,Ali, AU - Arnett,Donna K, AU - Polak,Joseph F, AU - Hundley,W Gregory, AU - Bluemke,David A, AU - Heckbert,Susan R, AU - Jacobs,David R,Jr AU - Nettleton,Jennifer A, Y1 - 2016/08/03/ PY - 2015/12/04/received PY - 2016/06/27/accepted PY - 2016/8/5/entrez PY - 2016/8/5/pubmed PY - 2017/6/7/medline KW - Mediterranean diet pattern KW - cardiovascular disease KW - epidemiology KW - left ventricular function KW - left ventricular structure KW - subclinical cardiovascular disease SP - 595 EP - 602 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 104 IS - 3 N2 - BACKGROUND: Data are limited on the relation between dietary patterns and left ventricular (LV) structure and function. OBJECTIVE: We examined cross-sectional associations of a diet-score assessment of a Mediterranean dietary pattern with LV mass, volume, mass-to-volume ratio, stroke volume, and ejection fraction. DESIGN: We measured LV variables with the use of cardiac MRI in 4497 participants in the Multi-Ethnic Study of Atherosclerosis study who were aged 45-84 y and without clinical cardiovascular disease. We calculated a Mediterranean diet score from intakes of fruit, vegetables, nuts, legumes, whole grains, fish, red meat, the monounsaturated fat:saturated fat ratio, and alcohol that were self-reported with the use of a food-frequency questionnaire. We used linear regression with adjustment for body size, physical activity, and cardiovascular disease risk factors to model associations and assess the shape of these associations (linear or quadratic). RESULTS: The Mediterranean diet score had a slight U-shaped association with LV mass (adjusted means: 146, 145, 146, and 147 g across quartiles of diet score, respectively; P-quadratic trend = 0.04). The score was linearly associated with LV volume, stroke volume, and ejection fraction: for each +1-U difference in score, LV volume was 0.4 mL higher (95% CI: 0.0, 0.8 mL higher), the stroke volume was 0.5 mL higher (95% CI: 0.2, 0.8 mL higher), and the ejection fraction was 0.2 percentage points higher (95% CI: 0.1, 0.3 percentage points higher). The score was not associated with the mass-to-volume ratio. CONCLUSIONS: A higher Mediterranean diet score is cross-sectionally associated with a higher LV mass, which is balanced by a higher LV volume as well as a higher ejection fraction and stroke volume. Participants in this healthy, multiethnic sample whose dietary patterns most closely conformed to a Mediterranean-type pattern had a modestly better LV structure and function than did participants with less-Mediterranean-like dietary patterns. This trial was registered at clinicaltrials.gov as NCT00005487. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/27488238/Mediterranean_diet_score_and_left_ventricular_structure_and_function:_the_Multi_Ethnic_Study_of_Atherosclerosis_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.128579 DB - PRIME DP - Unbound Medicine ER -