Tags

Type your tag names separated by a space and hit enter

Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease.
Respir Med. 2016 08; 117:40-7.RM

Abstract

BACKGROUND

The aim of this study was to evaluate the incidence and clinical features of patients who developed collagen vascular disease (CVD) after an initial diagnosis of idiopathic nonspecific interstitial pneumonia (NSIP).

METHODS

We conducted a retrospective review of 72 consecutive patients with NSIP who were diagnosed by surgical lung biopsy in our institution (idiopathic NSIP, n = 35; CVD-NSIP, n = 37 at initial diagnosis). No patients fulfilled the American College of Rheumatology criteria for a diagnosis with CVD within six months after the diagnosis of idiopathic NSIP.

RESULTS

Of 35 patients initially diagnosed with idiopathic NSIP, six patients (17.1%) developed CVD during the follow-up period (5.5 ± 5.0 years); three patients were diagnosed with dermatomyositis (DM), two patients with overlap syndrome (DM and Sjogren's syndrome), and one patient with rheumatoid arthritis. The mean time until CVD diagnosis was 2.0 years (six months - 3.5 years), and the one-, two- and three-year incidences of CVD development were 3.6%, 15.2% and 20.0%, respectively. There was no significant difference in clinical characteristics and survival among patients with NSIP preceding CVD diagnosis, those with idiopathic NSIP, or those with CVD-NSIP. In addition, at the time of initial diagnosis, there was no significant difference for the fulfillment of previous criteria such as interstitial pneumonia with autoimmune feature (IPAF) between patients with NSIP preceding CVD diagnosis and those with idiopathic NSIP.

CONCLUSIONS

It is difficult to predict CVD occurrence and careful attention is needed to detect the development of CVD in patients with idiopathic NSIP.

Authors+Show Affiliations

Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: nakayuta@hama-med.ac.jp.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, USA.Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27492512

Citation

Kono, Masato, et al. "Nonspecific Interstitial Pneumonia Preceding Diagnosis of Collagen Vascular Disease." Respiratory Medicine, vol. 117, 2016, pp. 40-7.
Kono M, Nakamura Y, Yoshimura K, et al. Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease. Respir Med. 2016;117:40-7.
Kono, M., Nakamura, Y., Yoshimura, K., Enomoto, Y., Oyama, Y., Hozumi, H., Enomoto, N., Fujisawa, T., Inui, N., Hamada, E., Colby, T. V., Maekawa, M., & Suda, T. (2016). Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease. Respiratory Medicine, 117, 40-7. https://doi.org/10.1016/j.rmed.2016.05.030
Kono M, et al. Nonspecific Interstitial Pneumonia Preceding Diagnosis of Collagen Vascular Disease. Respir Med. 2016;117:40-7. PubMed PMID: 27492512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease. AU - Kono,Masato, AU - Nakamura,Yutaro, AU - Yoshimura,Katsuhiro, AU - Enomoto,Yasunori, AU - Oyama,Yoshiyuki, AU - Hozumi,Hironao, AU - Enomoto,Noriyuki, AU - Fujisawa,Tomoyuki, AU - Inui,Naoki, AU - Hamada,Etsuko, AU - Colby,Thomas V, AU - Maekawa,Masato, AU - Suda,Takafumi, Y1 - 2016/06/01/ PY - 2016/02/25/received PY - 2016/05/10/revised PY - 2016/05/31/accepted PY - 2016/8/6/entrez PY - 2016/8/6/pubmed PY - 2017/12/28/medline KW - Collagen vascular disease (CVD) KW - Connective tissue disease (CTD) KW - Idiopathic interstitial pneumonias (IIPs) KW - Interstitial pneumonia with autoimmune features (IPAF) KW - Nonspecific interstitial pneumonia (NSIP) SP - 40 EP - 7 JF - Respiratory medicine JO - Respir Med VL - 117 N2 - BACKGROUND: The aim of this study was to evaluate the incidence and clinical features of patients who developed collagen vascular disease (CVD) after an initial diagnosis of idiopathic nonspecific interstitial pneumonia (NSIP). METHODS: We conducted a retrospective review of 72 consecutive patients with NSIP who were diagnosed by surgical lung biopsy in our institution (idiopathic NSIP, n = 35; CVD-NSIP, n = 37 at initial diagnosis). No patients fulfilled the American College of Rheumatology criteria for a diagnosis with CVD within six months after the diagnosis of idiopathic NSIP. RESULTS: Of 35 patients initially diagnosed with idiopathic NSIP, six patients (17.1%) developed CVD during the follow-up period (5.5 ± 5.0 years); three patients were diagnosed with dermatomyositis (DM), two patients with overlap syndrome (DM and Sjogren's syndrome), and one patient with rheumatoid arthritis. The mean time until CVD diagnosis was 2.0 years (six months - 3.5 years), and the one-, two- and three-year incidences of CVD development were 3.6%, 15.2% and 20.0%, respectively. There was no significant difference in clinical characteristics and survival among patients with NSIP preceding CVD diagnosis, those with idiopathic NSIP, or those with CVD-NSIP. In addition, at the time of initial diagnosis, there was no significant difference for the fulfillment of previous criteria such as interstitial pneumonia with autoimmune feature (IPAF) between patients with NSIP preceding CVD diagnosis and those with idiopathic NSIP. CONCLUSIONS: It is difficult to predict CVD occurrence and careful attention is needed to detect the development of CVD in patients with idiopathic NSIP. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/27492512/Nonspecific_interstitial_pneumonia_preceding_diagnosis_of_collagen_vascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(16)30117-2 DB - PRIME DP - Unbound Medicine ER -