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Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated with Altered Central Executive Network Community Structure during Cognitive Task.
PLoS One. 2016; 11(8):e0160214.Plos

Abstract

Older adults today consume more alcohol than previous generations, the majority being social drinkers. The effects of heavy alcohol use on brain functioning closely resemble age-related changes, but it is not known if moderate-heavy alcohol consumption intensifies brain aging. Whether a lifestyle of moderate-heavy alcohol use in older adults increased age-related brain changes was examined. Forty-one older adults (65-80 years) that consumed light (< 2 drinks/week and ≥ 1 drink/month, n = 20) or moderate-heavy (7-21 drinks/week, non-bingers, n = 21) amounts of alcohol were enrolled. Twenty-two young adults (24-35 years) were also enrolled (light, n = 11 and moderate-heavy, n = 11). Functional brain networks based on magnetic resonance imaging data were generated for resting state and during a working memory task. Whole-brain, Central Executive Network (CEN), and Default Mode Network (DMN) connectivity were assessed in light and moderate-heavy alcohol consuming older adults with comparisons to young adults. The older adults had significantly lower whole brain connectivity (global efficiency) and lower regional connectivity (community structure) in the CEN during task and in the DMN at rest. Moderate-heavy older drinkers did not exhibit whole brain connectivity differences compared to the low drinkers. However, decreased CEN connectivity was observed during the task. There were no differences in the DMN connectivity between drinking groups. Taken together, a lifestyle including moderate-heavy alcohol consumption may be associated with further decreases in brain network connectivity within task-related networks in older adults. Further research is required to determine if this decrease is compensatory or an early sign of decline.

Authors+Show Affiliations

Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.Department of Physiology and Pharmacology, Wake Forest School Medicine, Winston-Salem, North Carolina, United States of America.Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27494180

Citation

Mayhugh, Rhiannon E., et al. "Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated With Altered Central Executive Network Community Structure During Cognitive Task." PloS One, vol. 11, no. 8, 2016, pp. e0160214.
Mayhugh RE, Moussa MN, Simpson SL, et al. Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated with Altered Central Executive Network Community Structure during Cognitive Task. PLoS One. 2016;11(8):e0160214.
Mayhugh, R. E., Moussa, M. N., Simpson, S. L., Lyday, R. G., Burdette, J. H., Porrino, L. J., & Laurienti, P. J. (2016). Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated with Altered Central Executive Network Community Structure during Cognitive Task. PloS One, 11(8), e0160214. https://doi.org/10.1371/journal.pone.0160214
Mayhugh RE, et al. Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated With Altered Central Executive Network Community Structure During Cognitive Task. PLoS One. 2016;11(8):e0160214. PubMed PMID: 27494180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated with Altered Central Executive Network Community Structure during Cognitive Task. AU - Mayhugh,Rhiannon E, AU - Moussa,Malaak N, AU - Simpson,Sean L, AU - Lyday,Robert G, AU - Burdette,Jonathan H, AU - Porrino,Linda J, AU - Laurienti,Paul J, Y1 - 2016/08/05/ PY - 2016/03/01/received PY - 2016/07/16/accepted PY - 2016/8/6/entrez PY - 2016/8/6/pubmed PY - 2017/8/2/medline SP - e0160214 EP - e0160214 JF - PloS one JO - PLoS One VL - 11 IS - 8 N2 - Older adults today consume more alcohol than previous generations, the majority being social drinkers. The effects of heavy alcohol use on brain functioning closely resemble age-related changes, but it is not known if moderate-heavy alcohol consumption intensifies brain aging. Whether a lifestyle of moderate-heavy alcohol use in older adults increased age-related brain changes was examined. Forty-one older adults (65-80 years) that consumed light (< 2 drinks/week and ≥ 1 drink/month, n = 20) or moderate-heavy (7-21 drinks/week, non-bingers, n = 21) amounts of alcohol were enrolled. Twenty-two young adults (24-35 years) were also enrolled (light, n = 11 and moderate-heavy, n = 11). Functional brain networks based on magnetic resonance imaging data were generated for resting state and during a working memory task. Whole-brain, Central Executive Network (CEN), and Default Mode Network (DMN) connectivity were assessed in light and moderate-heavy alcohol consuming older adults with comparisons to young adults. The older adults had significantly lower whole brain connectivity (global efficiency) and lower regional connectivity (community structure) in the CEN during task and in the DMN at rest. Moderate-heavy older drinkers did not exhibit whole brain connectivity differences compared to the low drinkers. However, decreased CEN connectivity was observed during the task. There were no differences in the DMN connectivity between drinking groups. Taken together, a lifestyle including moderate-heavy alcohol consumption may be associated with further decreases in brain network connectivity within task-related networks in older adults. Further research is required to determine if this decrease is compensatory or an early sign of decline. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27494180/Moderate_Heavy_Alcohol_Consumption_Lifestyle_in_Older_Adults_Is_Associated_with_Altered_Central_Executive_Network_Community_Structure_during_Cognitive_Task_ L2 - https://dx.plos.org/10.1371/journal.pone.0160214 DB - PRIME DP - Unbound Medicine ER -