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Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.
J Natl Compr Canc Netw 2016; 14(8):1010-30JN

Abstract

This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

Authors

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Pub Type(s)

Journal Article
Practice Guideline

Language

eng

PubMed ID

27496117

Citation

Provenzale, Dawn, et al. "Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology." Journal of the National Comprehensive Cancer Network : JNCCN, vol. 14, no. 8, 2016, pp. 1010-30.
Provenzale D, Gupta S, Ahnen DJ, et al. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016;14(8):1010-30.
Provenzale, D., Gupta, S., Ahnen, D. J., Bray, T., Cannon, J. A., Cooper, G., ... Darlow, S. (2016). Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN, 14(8), pp. 1010-30.
Provenzale D, et al. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016;14(8):1010-30. PubMed PMID: 27496117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. AU - Provenzale,Dawn, AU - Gupta,Samir, AU - Ahnen,Dennis J, AU - Bray,Travis, AU - Cannon,Jamie A, AU - Cooper,Gregory, AU - David,Donald S, AU - Early,Dayna S, AU - Erwin,Deborah, AU - Ford,James M, AU - Giardiello,Francis M, AU - Grady,William, AU - Halverson,Amy L, AU - Hamilton,Stanley R, AU - Hampel,Heather, AU - Ismail,Mohammad K, AU - Klapman,Jason B, AU - Larson,David W, AU - Lazenby,Audrey J, AU - Lynch,Patrick M, AU - Mayer,Robert J, AU - Ness,Reid M, AU - Regenbogen,Scott E, AU - Samadder,Niloy Jewel, AU - Shike,Moshe, AU - Steinbach,Gideon, AU - Weinberg,David, AU - Dwyer,Mary, AU - Darlow,Susan, PY - 2016/8/7/entrez PY - 2016/8/9/pubmed PY - 2017/10/20/medline SP - 1010 EP - 30 JF - Journal of the National Comprehensive Cancer Network : JNCCN JO - J Natl Compr Canc Netw VL - 14 IS - 8 N2 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers. SN - 1540-1413 UR - https://www.unboundmedicine.com/medline/citation/27496117/Genetic/Familial_High_Risk_Assessment:_Colorectal_Version_1_2016_NCCN_Clinical_Practice_Guidelines_in_Oncology_ L2 - https://jnccn.org/doi/10.6004/jnccn.2016.0108 DB - PRIME DP - Unbound Medicine ER -