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Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.

Abstract

This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

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  • Authors

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    MeSH

    Colorectal Neoplasms
    Colorectal Neoplasms, Hereditary Nonpolyposis
    Disease Management
    Early Detection of Cancer
    Germ-Line Mutation
    Humans
    Population Surveillance
    Risk Assessment

    Pub Type(s)

    Journal Article
    Practice Guideline

    Language

    eng

    PubMed ID

    27496117

    Citation

    Provenzale, Dawn, et al. "Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology." Journal of the National Comprehensive Cancer Network : JNCCN, vol. 14, no. 8, 2016, pp. 1010-30.
    Provenzale D, Gupta S, Ahnen DJ, et al. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016;14(8):1010-30.
    Provenzale, D., Gupta, S., Ahnen, D. J., Bray, T., Cannon, J. A., Cooper, G., ... Darlow, S. (2016). Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN, 14(8), pp. 1010-30.
    Provenzale D, et al. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016;14(8):1010-30. PubMed PMID: 27496117.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. AU - Provenzale,Dawn, AU - Gupta,Samir, AU - Ahnen,Dennis J, AU - Bray,Travis, AU - Cannon,Jamie A, AU - Cooper,Gregory, AU - David,Donald S, AU - Early,Dayna S, AU - Erwin,Deborah, AU - Ford,James M, AU - Giardiello,Francis M, AU - Grady,William, AU - Halverson,Amy L, AU - Hamilton,Stanley R, AU - Hampel,Heather, AU - Ismail,Mohammad K, AU - Klapman,Jason B, AU - Larson,David W, AU - Lazenby,Audrey J, AU - Lynch,Patrick M, AU - Mayer,Robert J, AU - Ness,Reid M, AU - Regenbogen,Scott E, AU - Samadder,Niloy Jewel, AU - Shike,Moshe, AU - Steinbach,Gideon, AU - Weinberg,David, AU - Dwyer,Mary, AU - Darlow,Susan, PY - 2016/8/7/entrez PY - 2016/8/9/pubmed PY - 2017/10/20/medline SP - 1010 EP - 30 JF - Journal of the National Comprehensive Cancer Network : JNCCN JO - J Natl Compr Canc Netw VL - 14 IS - 8 N2 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers. SN - 1540-1413 UR - https://www.unboundmedicine.com/medline/citation/27496117/Genetic/Familial_High_Risk_Assessment:_Colorectal_Version_1_2016_NCCN_Clinical_Practice_Guidelines_in_Oncology_ L2 - http://www.jnccn.org/cgi/pmidlookup?view=long&pmid=27496117 DB - PRIME DP - Unbound Medicine ER -