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Differential deviant probability effects on two hierarchical levels of the auditory novelty system.
Biol Psychol. 2016 10; 120:1-9.BP

Abstract

Deviance detection is a key functional property of the auditory system that allows pre-attentive discrimination of incoming stimuli not conforming to a rule extracted from the ongoing constant stimulation, thereby proving that regularities in the auditory scene have been encoded in the auditory system. Using simple-feature stimulus deviations, regularity encoding and deviance detection have been reported in brain responses at multiple latencies of the human Auditory Evoked Potential (AEP), such as the Mismatch Negativity (MMN; peaking at 100-250ms from stimulus onset) and Middle-Latency Responses (MLR; peaking at 12-50ms). More complex levels of regularity violations, however, are only indexed by AEPs generated at higher stages of the auditory system, suggesting a hierarchical organization in the encoding of auditory regularities. The aim of the current study is to further characterize the auditory hierarchy of novelty responses, by assessing the sensitivity of MLR components to deviant probability manipulations. MMNs and MLRs were recorded in 24 healthy participants, using an oddball location paradigm with three different deviant probabilities (5%, 10% and 20%), and a reversed-standard (91.5%). We analyzed differences in the MLRs elicited to each of the deviant stimuli and the reversed-standard, as well as within deviant stimuli. Our results confirmed deviance detection at the level of both MLRs and MMN, but significant differences for deviant probabilities were found only for the MMN. These results suggest a functional dissociation between regularity encoding, already present at early stages of auditory processing, and the encoding of the probability with which this regularity is disrupted, which is only processed at higher stages of the auditory hierarchy.

Authors+Show Affiliations

Brainlab-Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig de la vall d'Hebron 171, 08035 Barcelona, Catalonia, Spain; Institute Neurosciences, University of Barcelona, Passeig de la Vall d'Hebron 171, 08035 Barcelona, Catalonia, Spain.Brainlab-Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig de la vall d'Hebron 171, 08035 Barcelona, Catalonia, Spain; Institute Neurosciences, University of Barcelona, Passeig de la Vall d'Hebron 171, 08035 Barcelona, Catalonia, Spain.Brainlab-Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig de la vall d'Hebron 171, 08035 Barcelona, Catalonia, Spain; Institute Neurosciences, University of Barcelona, Passeig de la Vall d'Hebron 171, 08035 Barcelona, Catalonia, Spain; Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address: cescera@ub.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27497593

Citation

López-Caballero, Fran, et al. "Differential Deviant Probability Effects On Two Hierarchical Levels of the Auditory Novelty System." Biological Psychology, vol. 120, 2016, pp. 1-9.
López-Caballero F, Zarnowiec K, Escera C. Differential deviant probability effects on two hierarchical levels of the auditory novelty system. Biol Psychol. 2016;120:1-9.
López-Caballero, F., Zarnowiec, K., & Escera, C. (2016). Differential deviant probability effects on two hierarchical levels of the auditory novelty system. Biological Psychology, 120, 1-9. https://doi.org/10.1016/j.biopsycho.2016.08.001
López-Caballero F, Zarnowiec K, Escera C. Differential Deviant Probability Effects On Two Hierarchical Levels of the Auditory Novelty System. Biol Psychol. 2016;120:1-9. PubMed PMID: 27497593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential deviant probability effects on two hierarchical levels of the auditory novelty system. AU - López-Caballero,Fran, AU - Zarnowiec,Katarzyna, AU - Escera,Carles, Y1 - 2016/08/03/ PY - 2016/01/06/received PY - 2016/06/16/revised PY - 2016/08/02/accepted PY - 2016/10/19/pubmed PY - 2017/9/14/medline PY - 2016/8/8/entrez KW - Auditory evoked potential KW - Deviance detection KW - Deviant probability KW - Middle-latency response KW - Mismatch negativity SP - 1 EP - 9 JF - Biological psychology JO - Biol Psychol VL - 120 N2 - Deviance detection is a key functional property of the auditory system that allows pre-attentive discrimination of incoming stimuli not conforming to a rule extracted from the ongoing constant stimulation, thereby proving that regularities in the auditory scene have been encoded in the auditory system. Using simple-feature stimulus deviations, regularity encoding and deviance detection have been reported in brain responses at multiple latencies of the human Auditory Evoked Potential (AEP), such as the Mismatch Negativity (MMN; peaking at 100-250ms from stimulus onset) and Middle-Latency Responses (MLR; peaking at 12-50ms). More complex levels of regularity violations, however, are only indexed by AEPs generated at higher stages of the auditory system, suggesting a hierarchical organization in the encoding of auditory regularities. The aim of the current study is to further characterize the auditory hierarchy of novelty responses, by assessing the sensitivity of MLR components to deviant probability manipulations. MMNs and MLRs were recorded in 24 healthy participants, using an oddball location paradigm with three different deviant probabilities (5%, 10% and 20%), and a reversed-standard (91.5%). We analyzed differences in the MLRs elicited to each of the deviant stimuli and the reversed-standard, as well as within deviant stimuli. Our results confirmed deviance detection at the level of both MLRs and MMN, but significant differences for deviant probabilities were found only for the MMN. These results suggest a functional dissociation between regularity encoding, already present at early stages of auditory processing, and the encoding of the probability with which this regularity is disrupted, which is only processed at higher stages of the auditory hierarchy. SN - 1873-6246 UR - https://www.unboundmedicine.com/medline/citation/27497593/Differential_deviant_probability_effects_on_two_hierarchical_levels_of_the_auditory_novelty_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0511(16)30253-8 DB - PRIME DP - Unbound Medicine ER -