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The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy.
Life Sci. 2016 Oct 01; 162:54-9.LS

Abstract

Diabetic retinopathy (DR) is a remarkable microvascular complication of diabetes and it has been considered the leading cause of legal blindness in working-age adults in the world. Several overlapping and interrelated molecular pathways are involved in the development of this disease. DR is staged into different levels of severity, from the nonproliferative to the advanced proliferative form. Over the years the progression of DR evolves through a series of changes involving distinct types of specialized cells: neural, vascular and glial. Prior to the clinically observable vascular complications, hyperglycemia and inflammation affect retinal glial cells which undergo a wide range of structural and functional alterations. In this review, we provide an overview of the status of macroglia and microglia in the course of DR, trying to briefly take into account the complex biochemical mechanisms that affect the intimate relationship among neuroretina, vessels and glial cells.

Authors+Show Affiliations

Department of Surgical Sciences, Unit of Ophthalmology, Ospedale Maggiore, Bologna, Italy. Electronic address: dr.fsorrentino@gmail.com.Department of Biomedical and Surgical Sciences, Division of Ophthalmology, University of Ferrara, Ferrara, Italy.Department of Biomedical and Surgical Sciences, Division of Ophthalmology, University of Ferrara, Ferrara, Italy.Department of Biomedical and Surgical Sciences, Section of Human Physiology, University of Ferrara, Ferrara, Italy.Department of Biomedical and Surgical Sciences, Division of Ophthalmology, University of Ferrara, Ferrara, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27497914

Citation

Sorrentino, Francesco Saverio, et al. "The Importance of Glial Cells in the Homeostasis of the Retinal Microenvironment and Their Pivotal Role in the Course of Diabetic Retinopathy." Life Sciences, vol. 162, 2016, pp. 54-9.
Sorrentino FS, Allkabes M, Salsini G, et al. The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy. Life Sci. 2016;162:54-9.
Sorrentino, F. S., Allkabes, M., Salsini, G., Bonifazzi, C., & Perri, P. (2016). The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy. Life Sciences, 162, 54-9. https://doi.org/10.1016/j.lfs.2016.08.001
Sorrentino FS, et al. The Importance of Glial Cells in the Homeostasis of the Retinal Microenvironment and Their Pivotal Role in the Course of Diabetic Retinopathy. Life Sci. 2016 Oct 1;162:54-9. PubMed PMID: 27497914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy. AU - Sorrentino,Francesco Saverio, AU - Allkabes,Michael, AU - Salsini,Giulia, AU - Bonifazzi,Claudio, AU - Perri,Paolo, Y1 - 2016/08/03/ PY - 2016/05/14/received PY - 2016/07/24/revised PY - 2016/08/02/accepted PY - 2016/8/8/entrez PY - 2016/8/9/pubmed PY - 2017/2/18/medline KW - Astrocytes KW - Diabetic retinopathy KW - Glial cells KW - Microglial cells KW - Müller cells SP - 54 EP - 9 JF - Life sciences JO - Life Sci VL - 162 N2 - Diabetic retinopathy (DR) is a remarkable microvascular complication of diabetes and it has been considered the leading cause of legal blindness in working-age adults in the world. Several overlapping and interrelated molecular pathways are involved in the development of this disease. DR is staged into different levels of severity, from the nonproliferative to the advanced proliferative form. Over the years the progression of DR evolves through a series of changes involving distinct types of specialized cells: neural, vascular and glial. Prior to the clinically observable vascular complications, hyperglycemia and inflammation affect retinal glial cells which undergo a wide range of structural and functional alterations. In this review, we provide an overview of the status of macroglia and microglia in the course of DR, trying to briefly take into account the complex biochemical mechanisms that affect the intimate relationship among neuroretina, vessels and glial cells. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/27497914/The_importance_of_glial_cells_in_the_homeostasis_of_the_retinal_microenvironment_and_their_pivotal_role_in_the_course_of_diabetic_retinopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(16)30463-5 DB - PRIME DP - Unbound Medicine ER -