Tags

Type your tag names separated by a space and hit enter

Is there a role for gut microbiota in type 1 diabetes pathogenesis?
Ann Med. 2017 02; 49(1):11-22.AM

Abstract

Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by insufficient insulin production due to the destruction of insulin secreting β-cells in the Langerhans islets. A variety of factors, including chemicals, viruses, commensal bacteria and diet have been proposed to contribute to the risk of developing the disorder. In the last years, gut microbiota has been proposed as a main factor in T1D pathogenesis. Several alterations of gut microbiota composition were described both in animal model and in humans. The decrease of Firmicutes/Bacteroides ratio was the most frequent pattern described, in particular, in human studies. Furthermore, Bacteroides, Clostridium cluster XIVa, Lactobacillus, Bifidobacterium, and Prevotella relative abundances were different in healthy and affected subjects. Dysbiosis would seem to increase intestinal permeability and thus promote the development of a pro-inflammatory niche that stimulates β-cell autoimmunity in predisposed subjects. Preliminary studies on animal models were realized to investigate the role of gut microbiota modulation as therapy or prevention approach in predisposed animals: promising and stimulating results have been reported. Key message Dietary antigens and microbiota-derived products might act as triggers of T1D by causing a pro-inflammatory and metabolic dysfunctional environment.

Authors+Show Affiliations

a Department of Clinical and Experimental Medicine , University of Sassari , Sassari , Italy.a Department of Clinical and Experimental Medicine , University of Sassari , Sassari , Italy.a Department of Clinical and Experimental Medicine , University of Sassari , Sassari , Italy.a Department of Clinical and Experimental Medicine , University of Sassari , Sassari , Italy.b Azienda Ospedaliero-Universitaria di Sassari , Sassari , Italy.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27499366

Citation

Bibbò, Stefano, et al. "Is There a Role for Gut Microbiota in Type 1 Diabetes Pathogenesis?" Annals of Medicine, vol. 49, no. 1, 2017, pp. 11-22.
Bibbò S, Dore MP, Pes GM, et al. Is there a role for gut microbiota in type 1 diabetes pathogenesis? Ann Med. 2017;49(1):11-22.
Bibbò, S., Dore, M. P., Pes, G. M., Delitala, G., & Delitala, A. P. (2017). Is there a role for gut microbiota in type 1 diabetes pathogenesis? Annals of Medicine, 49(1), 11-22. https://doi.org/10.1080/07853890.2016.1222449
Bibbò S, et al. Is There a Role for Gut Microbiota in Type 1 Diabetes Pathogenesis. Ann Med. 2017;49(1):11-22. PubMed PMID: 27499366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there a role for gut microbiota in type 1 diabetes pathogenesis? AU - Bibbò,Stefano, AU - Dore,Maria Pina, AU - Pes,Giovanni Mario, AU - Delitala,Giuseppe, AU - Delitala,Alessandro P, Y1 - 2016/11/29/ PY - 2016/8/9/pubmed PY - 2017/11/29/medline PY - 2016/8/9/entrez KW - Dysbiosis KW - autoimmunity KW - gut permeability KW - prevention KW - probiotic KW - therapy KW - type 1 diabetes mellitus SP - 11 EP - 22 JF - Annals of medicine JO - Ann. Med. VL - 49 IS - 1 N2 - Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by insufficient insulin production due to the destruction of insulin secreting β-cells in the Langerhans islets. A variety of factors, including chemicals, viruses, commensal bacteria and diet have been proposed to contribute to the risk of developing the disorder. In the last years, gut microbiota has been proposed as a main factor in T1D pathogenesis. Several alterations of gut microbiota composition were described both in animal model and in humans. The decrease of Firmicutes/Bacteroides ratio was the most frequent pattern described, in particular, in human studies. Furthermore, Bacteroides, Clostridium cluster XIVa, Lactobacillus, Bifidobacterium, and Prevotella relative abundances were different in healthy and affected subjects. Dysbiosis would seem to increase intestinal permeability and thus promote the development of a pro-inflammatory niche that stimulates β-cell autoimmunity in predisposed subjects. Preliminary studies on animal models were realized to investigate the role of gut microbiota modulation as therapy or prevention approach in predisposed animals: promising and stimulating results have been reported. Key message Dietary antigens and microbiota-derived products might act as triggers of T1D by causing a pro-inflammatory and metabolic dysfunctional environment. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/27499366/Is_there_a_role_for_gut_microbiota_in_type_1_diabetes_pathogenesis L2 - http://www.tandfonline.com/doi/full/10.1080/07853890.2016.1222449 DB - PRIME DP - Unbound Medicine ER -